Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: Consequences for FK506 assimilation

Watkins, 1992, Drug metabolism by cytochromes P450 in the liver and small bowel, Gastrointestinal Pharmacol, 23, 511 Lo, 1999, P-glycoprotein and drug therapy in organ transplantation, J Clin Pharmacol, 39, 995, 10.1177/00912709922011755 De Wildt, 1999, Cytochrome P450 3A. Ontogeny and drug disposition, Clin Pharmacokinet, 37, 485, 10.2165/00003088-199937060-00004 Seifeldin, 1995, Drug interactions in transplantation, Clin Ther, 17, 1043, 10.1016/0149-2918(95)80084-0 Christians, 2002, Mechanisms of clinically relevant drug interactions associated with tacrolimus, Clin Pharmacokinet, 41, 813, 10.2165/00003088-200241110-00003 Van Roermund, 1982, Cimetidine prophylaxis after renal transplantation, Clin Nephrol, 18, 39 Walter, 1984, Effect of cimetidine on upper gastrointestinal bleeding after renal transplantation: a prospective study, BMJ, 289, 1175, 10.1136/bmj.289.6453.1175 Skala, 1997, Prophylaxis of acute gastroduodenal bleeding after renal transplantation, Transpl Int, 10, 375, 10.1111/j.1432-2277.1997.tb00932.x Furuta, 2001, Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidin and omeprazole, Xenobiotica, 31, 1, 10.1080/00498250110035615 Szutowski, 2002, In vivo effect of 5- and 8-methoxypsoralens and cimetidin on R,S-warfarin metabolism in rat, J Appl Toxicol, 22, 327, 10.1002/jat.867 Lindell, 2003, Variable expression of CYP and PGP genes in the human small intestine, Eur J Clin Invest, 33, 493, 10.1046/j.1365-2362.2003.01154.x Rendic, 1984, Cimetidine and ranitidine: Their interaction with human and pig liver microsomes and with purified cytochrome P-450, Eur J Drug Metab Pharmacokinet, 9, 195, 10.1007/BF03189641 Mion, 1995, Aminopyrine breath test: Development of a 13C-breath test for quantitative assessment of liver function in humans, Hepato-Gastroenterology, 42, 931 Lemahieu, 2003, Measurement of hepatic and intestinal cyp 3A4 and P-glycoprotein activity by means of a combined po and iv C14 erythromycin breath and urine test, Am J Physiol Gastrointest Liver Physiol, 285, 470, 10.1152/ajpgi.00028.2003 Boswell, 1998, Tacrolimus pharmacokinetics in BMT patients, Bone Marrow Transplant, 21, 23, 10.1038/sj.bmt.1701054 Ghoos, 1993, Measurement of gastric emptying rate of solids by means of a carbon labbelled octanoic breath test, Gastroenterology, 104, 1640, 10.1016/0016-5085(93)90640-X Evenepoel, 1997, Production of egg proteins, enriched with L-leucine-13C1, for the study of protein assimilation in humans using the breath test technique, J Nutr, 127, 327, 10.1093/jn/127.2.327 Maes, 1998, Gastric emptying flow curves separated from carbon-labeled octanoic acid breath test results, Am J Physiol Gastrointest Liver Physiol, 275, 169, 10.1152/ajpgi.1998.275.1.G169 Irving, 1982, The aminopyrin breath test as a measure of liver function, J Lab Clin Med, 100, 3563 Plosker, 2000, Tacrolimus: A further update of its pharmacology and therapeutic use in the management of organ transplantation, Drugs, 59, 323, 10.2165/00003495-200059020-00021 Undre, 1998, European Tacrolimus Multicentre Renal Study Group. Factors affecting the pharmacokinetics of tacrolimus in the first year after renal transplantation, Transplant Proc, 30, 1261, 10.1016/S0041-1345(98)00234-6 Shimada, 2002, Lowered blood concentration of tacrolimus and its recovery with changes in expression of cyp3A and P-glycoprotein after high-dose steroid therapy, Transplantation, 74, 1419, 10.1097/00007890-200211270-00014 Andreev, 1999, A rise in plasma creatinine that is not a sign of renal failure: Which drugs can be responsible?, J Intern Med, 246, 247, 10.1046/j.1365-2796.1999.00515.x Niwa, 1999, Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine, Xenobiotica, 29, 187, 10.1080/004982599238731 Parker, 1997, Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test, Br J Clin Pharmacol, 43, 467, 10.1046/j.1365-2125.1997.00589.x Loi, 1997, Aging and drug interactions. III. Individual and combined effects of cimetidin and cimetidin and ciprofloxacin on theophyllin metabolism in healthy male and female nonsmokers, J Pharmacol Exp Ther, 280, 627 Mojtahedzadeh, 2003, Determination of theophyllin clearance after cimetidin infusion in critically ill patients, J Infus Nurs, 26, 234, 10.1097/00129804-200307000-00008 O'Reilly, 1984, Comparative interaction of cimetidin and ranitidin with racemic warfarin in man, Arch Intern Med, 144, 989, 10.1001/archinte.1984.00350170143024 Heagerty, 1981, Influence of cimetidin on pharmacokinetics of propranolol, BMJ, 13, 1917, 10.1136/bmj.282.6280.1917 Curi-Pedrosa, 1994, Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture, J Pharmacol Exp Ther, 269, 384 Raucy, 2003, Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products, Drug Metab Dispos, 31, 533, 10.1124/dmd.31.5.533 Reichenspurner, 1994, Changes of resorption and metabolism of cyclosporine after heart transplantation by the influence of gastrointestinal agents, Transplant Proc, 26, 2800 Shaefer, 1995, Evaluation of the pharmacokinetic interaction between cimetidine or famotidine and cyclosporine in healthy men, Ann Pharmacother, 29, 1088, 10.1177/106002809502901102 Puff, 1992, The effect of cimetidine on cyclosporine A levels in liver transplant recipients: A preliminary report, Am J Gastroenterol, 87, 287 Barri, 1996, Cimetidine or ranitidine in renal transplant patients receiving cyclosporine, Clin Transplant, 10, 34 Blohme, 1993, A study of the interaction between omeprazole and cyclosporine in renal transplant patients, Br J Clin Pharmacol, 35, 156 Lemahieu, 2004, CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporine vs. tacrolimus vs. sirolimus, Am J Tranplant, 4, 1514, 10.1111/j.1600-6143.2004.00539.x