Immunomodulation—A Molecular Solution to Treating Patients with Severe Bladder Pain Syndrome?

Dinarello, 2018, Overview of the IL-1 family in innate inflammation and acquired immunity, Immunol Rev, 281, 8, 10.1111/imr.12621 Schwab, 2013, Intravenous immunoglobulin therapy: how does IgG modulate the immune system?, Nat Rev Immunol, 13, 176, 10.1038/nri3401 Yokota, 2008, Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial, Lancet, 371, 998, 10.1016/S0140-6736(08)60454-7 Peters, 2009, Childhood symptoms and events in women with interstitial cystitis/painful bladder syndrome, Urology, 73, 258, 10.1016/j.urology.2008.09.014 Warren, 2008, Urinary tract infection and inflammation at onset of interstitial cystitis/painful bladder syndrome, Urology, 71, 1085, 10.1016/j.urology.2007.12.091 Bogart, 2007, Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review, J Urol, 177, 450, 10.1016/j.juro.2006.09.032 Jones, 1997, Epidemiology of interstitial cystitis, Urology, 49, 2, 10.1016/S0090-4295(99)80327-6 Pazin, 2016, Treatment of bladder pain syndrome and interstitial cystitis: a systematic review, Int Urogynecol J, 27, 697, 10.1007/s00192-015-2815-5 Khullar, 2019, How can we improve the diagnosis and management of bladder pain syndrome? Part 2: ICI-RS 2018, Neurourol Urodyn, 38, S71 Engeler, 2019, The 2019 EAU guidelines on chronic pelvic pain, EAU guidelines presented at the EAU Annual Congress Barcelona Ambite, 2016, Molecular basis of acute cystitis reveals susceptibility genes and immunotherapeutic targets, PLoS Pathog, 12, 10.1371/journal.ppat.1005848 Butler, 2018, Neuroepithelial control of mucosal inflammation in acute cystitis, Sci Rep, 8, 11015, 10.1038/s41598-018-28634-0 Puthia, 2016, IRF7 inhibition prevents destructive innate immunity-A target for nonantibiotic therapy of bacterial infections, Sci Transl Med, 8, 10.1126/scitranslmed.aaf1156 Kullenberg, 2016, Long-term safety profile of anakinra in patients with severe cryopyrin-associated periodic syndromes, Rheumatology (Oxford), 55, 1499, 10.1093/rheumatology/kew208 Schiff, 2004, The safety of anakinra in high-risk patients with active rheumatoid arthritis: six-month observations of patients with comorbid conditions, Arthritis Rheum, 50, 1752, 10.1002/art.20277 O’Leary, 1997, The interstitial cystitis symptom index and problem index, Urology, 49, 58, 10.1016/S0090-4295(99)80333-1 Rosenberg, 2005, Prevalence of interstitial cystitis symptoms in women: a population based study in the primary care office, J Urol, 174, 2231, 10.1097/01.ju.0000181203.82693.95 van de Merwe, 2008, Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal, Eur Urol, 53, 60, 10.1016/j.eururo.2007.09.019 Whitmore, 2019, Hunner lesion versus non-Hunner lesion interstitial cystitis/bladder pain syndrome, Int J Urol, 26, 26, 10.1111/iju.13971 R Development Core Team, 2019 Li, 2009, The sequence alignment/map format and SAMtools, Bioinformatics, 25, 2078, 10.1093/bioinformatics/btp352 Li, 2011, Tabix: fast retrieval of sequence features from generic TAB-delimited files, Bioinformatics, 27, 718, 10.1093/bioinformatics/btq671 Broz, 2016, Inflammasomes: mechanism of assembly, regulation and signalling, Nat Rev Immunol, 16, 407, 10.1038/nri.2016.58 Lingappa, 2011, Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure, PLoS One, 6, 10.1371/journal.pone.0028632 Tin, 2011, Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele, Hum Mol Genet, 20, 4056, 10.1093/hmg/ddr307 Cavalli, 2018, Anakinra therapy for non-cancer inflammatory diseases, Front Pharmacol, 9, 1157, 10.3389/fphar.2018.01157 Svanborg, 1999, Cytokine responses during mucosal infections: role in disease pathogenesis and host defence, Curr Opin Microbiol, 2, 99, 10.1016/S1369-5274(99)80017-4 Bosch, 2014, Examination of the significant placebo effect in the treatment of interstitial cystitis/bladder pain syndrome, Urology, 84, 321, 10.1016/j.urology.2014.04.011 Oken, 2008, Placebo effects: clinical aspects and neurobiology, Brain, 131, 2812, 10.1093/brain/awn116