Identification of a Family of Muscarinic Acetylcholine Receptor Genes

American Association for the Advancement of Science (AAAS) - Tập 237 Số 4814 - Trang 527-532 - 1987
Tom I. Bonner1, Noel J. Buckley1, Alice Young1, Mark R. Brann2
1Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892.
2Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD 20892.

Tóm tắt

Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence. This gene family provides a new basis for evaluating the diversity of muscarinic mechanisms in the nervous system.

Từ khóa


Tài liệu tham khảo

Bonner, T. I., Molecular Brain Research 2: 243 (1987).

BONNER T.I. unpublished data.

Brann, M. R., Molecular Pharmacology 32: 450 (1987).

CHUNG, F.Z., CLONING AND SEQUENCE-ANALYSIS OF THE HUMAN-BRAIN BETA-ADRENERGIC-RECEPTOR - EVOLUTIONARY RELATIONSHIP TO RODENT AND AVIAN BETA-RECEPTORS AND PORCINE MUSCARINIC RECEPTORS, FEBS LETTERS 211: 200 (1987).

Dayhoff, M. O., Atlas of Protein Sequence and Structure 5 3: 345 (1978).

10.1038/321075a0

10.1038/326073a0

EVANS, T, MOLECULAR PHARMACOLOGY 26: 395 (1984).

EVANS, T, GUANINE NUCLEOTIDE-SENSITIVE, HIGH-AFFINITY BINDING OF CARBACHOL TO MUSCARINIC CHOLINERGIC RECEPTORS OF 1321N1 ASTROCYTOMA-CELLS IS INSENSITIVE TO PERTUSSIS TOXIN, MOLECULAR PHARMACOLOGY 27: 32 (1985).

GILBERT, W, ON THE ANTIQUITY OF INTRONS, CELL 46: 151 (1986).

GILBERT, W, WHY GENES IN PIECES, NATURE 271: 501 (1978).

GILMAN, A.G., G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE, CELL 36: 577 (1984).

10.1016/0042-6822(73)90341-3

HAMMER, R, PIRENZEPINE DISTINGUISHES BETWEEN DIFFERENT SUBCLASSES OF MUSCARINIC RECEPTORS, NATURE 283: 90 (1980).

HARDEN, T.K., TRENDS IN PHARMACOLOGICAL SCIENCES 7 Supplement: 14 (1986).

KOBILKA, B.K., CDNA FOR THE HUMAN BETA-2-ADRENERGIC RECEPTOR - A PROTEIN WITH MULTIPLE MEMBRANE-SPANNING DOMAINS AND ENCODED BY A GENE WHOSE CHROMOSOMAL LOCATION IS SHARED WITH THAT OF THE RECEPTOR FOR PLATELET-DERIVED GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 84: 46 (1987).

KUBO, T, PRIMARY STRUCTURE OF PORCINE CARDIAC MUSCARINIC ACETYLCHOLINE-RECEPTOR DEDUCED FROM THE CDNA SEQUENCE, FEBS LETTERS 209: 367 (1986).

KUBO, T, CLONING, SEQUENCING AND EXPRESSION OF COMPLEMENTARY-DNA ENCODING THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, NATURE 323: 411 (1986).

LAWN, R.M., ISOLATION AND CHARACTERIZATION OF LINKED DELTA-GLOBIN AND BETA-GLOBIN GENES FROM A CLONED LIBRARY OF HUMAN DNA, CELL 15: 1157 (1978).

MISHINA, M, EXPRESSION OF FUNCTIONAL ACETYLCHOLINE-RECEPTOR FROM CLONED CDNAS, NATURE 307: 604 (1984).

MOUNT, S.M., A CATALOG OF SPLICE JUNCTION SEQUENCES, NUCLEIC ACIDS RESEARCH 10: 459 (1982).

NATHANS, J, ISOLATION, SEQUENCE-ANALYSIS, AND INTRON EXON ARRANGEMENT OF THE GENE ENCODING BOVINE RHODOPSIN, CELL 34: 807 (1983).

10.1126/science.2937147

NATHANSON, N.M., MOLECULAR-PROPERTIES OF THE MUSCARINIC ACETYLCHOLINE-RECEPTOR, ANNUAL REVIEW OF NEUROSCIENCE 10: 195 (1987).

OKAYAMA, H, A CDNA CLONING VECTOR THAT PERMITS EXPRESSION OF CDNA INSERTS IN MAMMALIAN-CELLS, MOLECULAR AND CELLULAR BIOLOGY 3: 280 (1983).

OVCHINNIKOV, Y.A., RHODOPSIN AND BACTERIORHODOPSIN - STRUCTURE-FUNCTION-RELATIONSHIPS, FEBS LETTERS 148: 179 (1982).

10.1126/science.3107123

SARGENT, T.D., RAT SERUM-ALBUMIN GENE - ANALYSIS OF CLONED SEQUENCES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 76: 3256 (1979).

SPIEGEL, A.M., SIGNAL TRANSDUCTION BY GUANINE-NUCLEOTIDE BINDING-PROTEINS, MOLECULAR AND CELLULAR ENDOCRINOLOGY 49: 1 (1987).

STRYER, L, ANNUAL REVIEW OF CELL BIOLOGY 2: 391 (1986).

YARDEN, Y, THE AVIAN BETA-ADRENERGIC-RECEPTOR - PRIMARY STRUCTURE AND MEMBRANE TOPOLOGY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 6795 (1986).

YOUNG, W.S., MESENCEPHALIC DOPAMINE NEURONS REGULATE THE EXPRESSION OF NEUROPEPTIDE MESSENGER-RNAS IN THE RAT FOREBRAIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 9827 (1986).