Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Nature - Tập 376 Số 6535 - Trang 37-43 - 1995
Donald W. Nicholson1, Ambereen Ali1, Nancy A. Thornberry2, John P. Vaillancourt1, Connie K. Ding3, Michel Gallant4, Yves Gareau4, Patrick R. Griffin3, Marc Labelle4, Yuri Lazebnik5, Neil A. Munday1, Sayyaparaju M. Raju3, Mark E. Smulson6, Ting-Ting Yamin3, Violeta Yu1, Douglas K. Miller3
1Departments of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, Quebec, H9R 4P8, Canada
2Department of Biochemistry, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey, 07065, USA
3Department of Inflammation Research, Merck Research Laboratories, PO Box 2000, Rahway, New Jersey, 07065, USA
4Departments of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, Quebec, H9R 4P8, Canada
5Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA.
6Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC, USA

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Tài liệu tham khảo

Kerr, J. F., Wyllie, A. H. & Currie, A. R. Br. J. Cancer 26, 239–257 (1972).

Martin, S. J., Green, D. R. & Cotter, T. G. Trends biochem. Sci. 19, 26–30 (1994).

Barr, P. J. & Tomei, L. D. Biotechnology 12, 487–493 (1994).

Carson, D. A. & Ribeiro, J. M. Lancet 341, 1251–1254 (1994).

Ellis, R. E., Yuan, J. & Horvitz, H. R. A. Rev. Cell Biol. 7, 663–698 (1991).

Yuan, J., Shaham, S., Ledoux, S., Ellis, J. M. & Horvitz, J. R. Cell 75, 641–652 (1993).

Thornberry, N. A. et al. Nature 356, 768–774 (1992).

Cerretti, D. P. et al. Science 256, 97–100 (1992).

Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A. & Yuan, J. Cell 78, 653–660 (1993).

Gagliardini, V. et al. Science 263, 826–828 (1994).

Juarez-Salinas, H., Sims, J. L. & Jacobson, M. K. Nature 282, 740–741 (1979).

Berger, N. A., Sikorski, G. W., Petzold, S. J. & Kurohara, K. K. Biochemistry 19, 289–293 (1980).

Satoh, M. S. & Lindahl, T. Nature 356, 356–358 (1992).

Ding, R., Pommier, Y., Kang, V. H. & Smulson, M. J. biol. Chem. 267, 12804–12812 (1992).

Smulson, M., Istock, N., Ding, R. & Cherney, B. Biochemistry 33, 6186–6194 (1994).

Ding, R. & Smulson, M. Cancer Res. 54, 4627–4634 (1994).

Burkle, A., Grube, K. & Küpper, J.-H. Expl clin. Immunogenet. 9, 230–240 (1992).

Wang, Z. Q. et al. Genes Dev. 9, 509–520 (1995).

Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. & Poirier, G. G. Cancer Res. 53, 3976–3985 (1993).

Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. & Earnshaw, W. C. Nature 371, 346–347 (1994).

Yoshihara, K., Tanigawa, Y. & Koide, S. S. Biochem. biophys. Res. Commun. 59, 658–665 (1974).

Yoshihara, K., Tanigawa, Y., Burzio, L. & Koide, S. S. Proc. natn. Acad. Sci. U.S.A. 72, 289–293 (1975).

Tanaka, Y., Yoshihara, K., Itaya, A., Kamiya, T. & Koide, S. S. J. biol. Chem. 259, 6579–6585 (1984).

Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G. & Jenkins, N. A. Genes Dev. 8, 1613–1626 (1994).

Wang, L., Miura, M., Bergeron, L., Zhu, J. & Yuan, J. Cell 78, 739–750 (1994).

Fernandes-Alnemri, T., Litwack, G. & Alnemri, E. S. J. biol. Chem. 269, 30761–30764 (1994).

Munday, N. A. et al. J. biol. Chem. 270, 15870–15876 (1995).

Williams, M. S. & HenKart, P. A. J. Immun. 153, 4247–4255 (1994).

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H. & Ley, T. J. Cell 76, 977–987 (1994).

Li, P. et al. Cell 80, 401–411 (1995).

Kuida, K. et al. Science 267, 2000–2003 (1995).

Enari, M., Hug, H. & Nagata, S. Nature 375, 78–81 (1995).

Los, M. et al. Nature 375, 81–83 (1995).

Ayala, J. M. et al. J. Immun. 153, 2592–2599 (1994).

Ray, C. A. et al. Cell 69, 597–604 (1992).

Howard, A. D. et al. J. Immun. 154, 2321–2332 (1995).

Wilson, K. P. et al. Nature 370, 270–275 (1994).

Walker, N. P. C. et al. Cell 78, 343–352 (1994).

Westerik, J. O. & Wolfenden, R. J. biol. Chem. 247, 8195–8197 (1972).

Solary, E., Bertrand, R., Kohn, K. W. & Pommier, Y. Blood 81, 1359–1368 (1993).

Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G. & Earnshaw, W. C. J. Cell Biol. 123, 7–22 (1993).

deMurcia, G., Ménissier-deMurcia, J. & Schreiber, V. BioEssays 13, 455–462 (1991).

Langlois, A. J., Lapis, K., Ishizaki, R., Beard, J. W. & Bolognesi, D. P. Cancer Res. 34, 1457–1464 (1974).

Cherney, B. W. et al. Proc. natn. Acad. Sci. U.S.A. 84, 8370–8374 (1987).

Chapman, K. T. Bioorg. Med. Chem. Lett. 2, 613–618 (1992).

Miller, D. K. et al. J. biol. Chem. 268, 18062–18069 (1993).

Devereux, J., Haeberli, P. & Smithies, O. Nucleic Acids Res. 12, 387–395 (1984).

Morrison, J. F. Trends biochem. Sci. 7, 102–105 (1982).