Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

Blood - Tập 127 Số 9 - Trang 1117-1127 - 2016
Joseph A. Fraietta1,2, Kyle A. Beckwith3, Prachi Patel1,2, Marco Ruella1,2, Zhaohui Zheng1,2, David M. Barrett4, Simon F. Lacey1,2, J. Joseph Melenhorst1,2, Shannon E. McGettigan1,2, Danielle Cook1,2, Changfeng Zhang1,2, Jun Xu1,2, Priscilla Do3, Jessica Hulitt4, Sagar B. Kudchodkar1,2, Alexandria P. Cogdill1,2, Saar Gill2,5, David L. Porter1,2,5, Jennifer A. Woyach3, Meixiao Long3, Amy J. Johnson3, Kami J. Maddocks3, Natarajan Muthusamy3, Bruce L. Levine1,2,6, Carl H. June1,2,6, Marcela V. Maus7
1Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
2Center for Cellular Immunotherapies and
3Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
4Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA
5Division of Hematology-Oncology, Department of Internal Medicine and
6Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; and
7Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA

Tóm tắt

Key Points

Ibrutinib treatment of CLL enhances the generation of CAR T cells for adoptive immunotherapy. Concurrent ibrutinib therapy improves the engraftment and therapeutic efficacy of anti-CD19 CAR T cells in mouse models.

Từ khóa


Tài liệu tham khảo

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