Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Tóm tắt
Từ khóa
Tài liệu tham khảo
Franceschi, 1995, The immunology of exceptional individuals: the lesson of centenarians, Immunol. Today, 16, 12, 10.1016/0167-5699(95)80064-6
Sansoni, 1993, Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians, Blood, 80, 2767, 10.1182/blood.V82.9.2767.2767
Mariotti, 1992, Thyroid and other organ-specific autoantibodies in healthy centenarians, Lancet, 33, 1506, 10.1016/0140-6736(92)91265-A
Paganelli, 1992, Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population, Clinl. Exp. Immunol., 90, 351, 10.1111/j.1365-2249.1992.tb07954.x
Fagiolo, 1993, Increased cytokine production in mononuclear cells of healthy elderly people, Eur. J. Immunol., 23, 2375, 10.1002/eji.1830230950
Cossarizza, 1996, CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to healthy centenarians: implications for T cell memory, Mech. Ageing Dev., 86, 173, 10.1016/0047-6374(95)01691-0
Fagnoni F, Vescovini R, Passeri G, Bologna G, Pedrazzoni M, Lavagetto G, Casti A, Franceschi C, Passeri M, Sansoni P. Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging. Blood, 2000 (in press).
Fagnoni, 1996, Expansion of cytotoxic CD8+CD28 T cells in healthy aged people and centenarians, Immunology, 88, 501, 10.1046/j.1365-2567.1996.d01-689.x
Wack, 1998, Age-related modifications of the human α/β T cell repertoire as a consequence of clonal expansions, Int. Immunol., 10, 1281, 10.1093/intimm/10.9.1281
Franceschi, 1999, Biomarkers of immunosenescence: the challenge of heterogeneity and the role of antigenic load, Exp Gerontol, 34, 911, 10.1016/S0531-5565(99)00068-6
Franceschi, 1995, Immunosenescence in humans: deterioration or remodeling?, Int. Rev. Immunol., 12, 57, 10.3109/08830189509056702
Ottaviani, 1997, The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine system, Immunol. Today, 18, 169, 10.1016/S0167-5699(97)84663-4
Bellavia, 1999, C4, BF, C3 allele distribution and complementary activity in healthy aged people and centenarians, J. Gerontol. Biol. Sci., 54:B, 150, 10.1093/gerona/54.4.B150
Franceschi, 1991, Aging, longevity and cancer: studies in Down’s syndrome and centenarians, Annals of the New York Academy of Sciences, 621, 428, 10.1111/j.1749-6632.1991.tb16997.x
Sansoni, 1997, T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians, Mech. Ageing Dev., 96, 127, 10.1016/S0047-6374(97)01887-3
Mondello, 1999, Telomere length in fibroblasts and blood cells from healthy centenarians, Exp. Cell Res., 248, 234, 10.1006/excr.1999.4398
Rufer, 1999, Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood, J Exp Med, 190, 157, 10.1084/jem.190.2.157
Campisi, 1997, Aging and cancer: the double-edged sword of replicative senescence, J. Am. Geriatr. Soc., 45, 482, 10.1111/j.1532-5415.1997.tb05175.x