Human Keratinocytes That Express hTERT and Also Bypass a p16INK4a-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

Molecular and Cellular Biology - Tập 20 Số 4 - Trang 1436-1447 - 2000
Mark A. Dickson1, William C. Hahn2,3, Yasushi Ino4, Vincent Ronfard5, Jenny Wu6, Robert A. Weinberg3, David N. Louis4, Frederick P. Li7, James G. Rheinwald6
1Division of Dermatology, Department of Medicine and Harvard Skin Disease Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
2Department of Adult Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital,3
3Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, 2 and
4Department of Pathology and Neurosurgical Service, Massachusetts General Hospital, 4 and
5Laboratory of Cell and Tissue Development, Organogenesis, Inc., Canton, 5 Massachusetts
6Division of Dermatology, Department of Medicine and Harvard Skin Disease Research Center, Brigham and Women's Hospital,1
7Department of Adult Oncology, Dana-Farber Cancer Institute, 6 Harvard Medical School, Boston,

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Molecular and Cellular Biology

Tập 20 Số 4

1436-1447

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