How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review

Kontoyiannis, 2014, Agents of mucormycosis and entomophthoramycosis, 2910 Skiada, 2013, European Conference on Infections in Leukemia. Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3), Haematologica, 98, 492, 10.3324/haematol.2012.065110 Walsh, 2008, Editorial commentary: what is the role of combination therapy in management of zygomycosis?, Clin. Infect. Dis., 47, 372, 10.1086/589858 Spellberg, 2009, Clin. Infect. Dis., 48, 1743, 10.1086/599105 Spellberg, 2005, Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice, Antimicrob. Agents Chemother., 49, 830, 10.1128/AAC.49.2.830-832.2005 Ibrahim, 2008, Combination echinocandin-polyene treatment of murine mucormycosis, Antimicrob. Agents Chemother., 52, 1556, 10.1128/AAC.01458-07 Vazquez, 2005, Successful treatment of rhinocerebral zygomycosis with a combination of caspofungin and liposomal amphotericin B, Haematologica Ojeda-Uribe, 2010, Lessons from a case of oromandibular mucormycosis treated with surgery and a combination of amphotericin B lipid formulation plus caspofungin, Acta Haematol., 124, 98, 10.1159/000315675 Reed, 2008, Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis, Clin. Infect. Dis., 47, 364, 10.1086/589857 R.H. Drew, C.A. Kauffman, A.R. Thorner, Pharmacology of amphotericin B. In: UpToDate, Post TW (Ed.), UpToDate, M.A. Waltham, (accessed on Oct 2013.) Rex, 2014, Drugs active against fungi, pneumocystis, and microsporidia, 480 Vehreschild, 2013, Mucormycosis treated with posaconazole: review of 96 case reports, Crit. Rev. Microbiol., 39, 310, 10.3109/1040841X.2012.711741 van Burik, 2006, Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases, Clin. Infect. Dis., 42, e61, 10.1086/500212 Greenberg, 2006, Posaconazole as salvage therapy for zygomycosis, Antimicrob. Agents Chemother., 50, 126, 10.1128/AAC.50.1.126-133.2006 Spellberg, 2012, Combination therapy for mucormycosis: why, what, and how?, Clin. Infect. Dis., 54, S73, 10.1093/cid/cir885