How do lipoxygenases control the stereochemistry of fatty acid oxygenation?

International Congress Series - Tập 1233 - Trang 291-296 - 2002
Hartmut Kühn1, Kristin Schwarz1, Sabine Borngräber1, Ralf J Kuban1
1Institute of Biochemistry, University Clinics Charité, Humboldt University, Hessische Str. 3-4, 10115 Berlin, Federal Republic of Germany

Tài liệu tham khảo

Brash, 1999, Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate, J. Biol. Chem., 274, 23679, 10.1074/jbc.274.34.23679 Schewe, 1986, Enzymology and physiology of reticulocyte lipoxygenase. Comparison with other lipoxygenases, Adv. Enzymol., 58, 191 Kuhn, 2000, Structural basis for the positional specificity of lipoxygenases, Prostaglandins Leukot. Lipid Med., 62, 255, 10.1016/S0090-6980(00)00084-8 Kühn, 1986, The stereochemistry of the reaction of lipoxygenases and their metabolites. A proposed nomenclature for lipoxygenases and related enzymes, Adv. Enzymol., 58, 273 Boyington, 1993, The three-dimensional structure of an arachidonic acid 15-lipoxygenase, Science, 260, 1482, 10.1126/science.8502991 Minor, 1996, Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution, Biochemistry, 35, 10687, 10.1021/bi960576u Skrzypczak-Jankun, 1997, Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme, Proteins, 29, 15, 10.1002/(SICI)1097-0134(199709)29:1<15::AID-PROT2>3.0.CO;2-E Gillmor, 1997, The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity, Nat. Struct. Biol., 4, 1003, 10.1038/nsb1297-1003 Borngräber, 1999, Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity, J. Biol. Chem., 274, 37345, 10.1074/jbc.274.52.37345 Schwarz, 2001, Structural basis of lipoxygenase specificity, J. Biol. Chem., 276, 773, 10.1074/jbc.M005114200 Kühn, 1990, Singular and dual positional specificity of lipoxygenases, J. Biol. Chem., 265, 16300, 10.1016/S0021-9258(17)46222-3 van Os, 1981, Double dioxygenation of arachidonic acid by soybean lipoxygenase-1. Kinetics and regio-stereo specificities of the reaction steps, Biochim. Biophys. Acta, 663, 177, 10.1016/0005-2760(81)90204-6 Schwarz, 1998, Probing the substrate alignment at the active site of 15-lipoxygenases by targeted substrate modification and site directed mutagenesis. Evidence for an inverse substrate orientation, Biochemistry, 37, 15327, 10.1021/bi9816204 Sloane, 1991, A primary determinant for lipoxygenase positional specificity, Nature, 354, 149, 10.1038/354149a0 Suzuki, 1994, Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase, Biochim. Biophys. Acta, 1210, 308, 10.1016/0005-2760(94)90234-8 Chen, 1993, Structure–function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies, FASEB J., 7, 694, 10.1096/fasebj.7.8.8500694 Jisaka, 2000, Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2, J. Biol. Chem., 275, 1287, 10.1074/jbc.275.2.1287 Gan, 1996, Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis, J. Biol. Chem., 271, 25412, 10.1074/jbc.271.41.25412