High-level expression of foreign genes in Hansenula polymorpha

Biotechnology Advances - Tập 10 - Trang 179-189 - 1992
Gerd Gellissen1, Zbigniew A. Janowicz1, Ulrike Weydemann1, Karl Melber1, Alexander W.M. Strasser1, Cornelis P Hollenberg2
1Rhein Biotech GmbH, Eichsfelder Str. 11, 4 Düsseldorf 13, Germany
2Institut für Mikrobiologie, Heinrich-Heine-Universität, Universitätsstr.1, 4 Düsseldorf 1, Germany

Tài liệu tham khảo

Buckholz, 1991, Yeast systems for the commercial production of heterologous proteins, Bio/Technology, 9, 1067, 10.1038/nbt1191-1067 Cregg, 1985, Pichia pastoris as a host system for transformations, Mol.Cell.Biol., 5, 3376, 10.1128/MCB.5.12.3376 Cregg, 1987, Development of yeast transformation systems and construction of methanol-utilizing-defective mutants of Pichia pastoris by gene disruption, Vol. 2, 1 Dohmen, 1990, Cloning of the Schwanniomyces occidentalis gene (Gam1) and its expression in S. cerevisiae, Gene, 95, 111, 10.1016/0378-1119(90)90421-M S.B. Ellis et al. Isolation of alcohol oxidase and two other methanol regulatable genes from the yeast, Pichia pastoris, Mol.Cell.Biol. 5:111–121 Emini, 1986, Production and analysis of recombinant hepatitis B vaccine, J. of Infection 13, 13, 3, 10.1016/S0163-4453(86)92563-6 G. Gellissen et al., Heterologous gene expression in Hansenula polymorpha: Efficient secretion of glucoamylase, Bio/Technology 9:291–295 G.Gellissen et al., Heterologous protein production in yeast, Antonie van Leeuwenhoek (in press) M.A. Gleeson et al., Transformation of the methylotrophic yeast Hansenula polymorpha, J.Gen.Micobiol. 132:3459–3465 Gleeson, 1988, The methylotrophic yeasts, Yeast, 4, 1, 10.1002/yea.320040102 Grinna, 1989, Size distribution and general structural features of N-linked oligosaccharides from the methylotrophic yeast, Pichia pastoris, Yeast, 4, 107, 10.1002/yea.320050206 C.P. Hollenberg and Z.A. Janowicz, DNA molecules coding for FMDH control regions and structured gene for protein having FMDH activity and their uses, European patent application EPA No 0299108 Innis, 1989, Glycosylation of heterologous proteins in Saccharomyces cerevisiae, 233 Janowicz, 1988, Expression system based on the methylotrophic yeast, Hansenula polymorpha, Yeast, 4S, 155 Janowicz, 1991, Simultaneous expression of the S and L surface antigens of hepatitis B and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha, Yeast, 7, 431, 10.1002/yea.320070502 Z.A. Janowicz et al., Expression of hepatitis B antigens in the methylotrophic yeast, Hansenula polymorpha. Formation of mixed particles, in Biotec 4: therapeutics, diagnostics, new vaccines, interferon treatment and plasma proteins, Hollenberg and Sahm (Eds), Gustav Fischer Verlag (in press) Julius, 1984, Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor, Cell, 37, 1075, 10.1016/0092-8674(84)90442-2 Koutz, 1987, Structural comparison of the Pichia pastoris alcohol oxidase genes, Yeast, 5, 167, 10.1002/yea.320050306 Ledeboer, 1985, Molecular cloning and characterization of a gene coding for methanol oxidase in Hansenula polymorpha, Nucleic Acids Res., 13, 3063, 10.1093/nar/13.9.3063 Neurath, 1987, Hepatitis B virus proteins eliciting protective immunogenicity, Microbiol. Sci., 4, 45 J. Petre et al., Development of a hepatitis B vaccine from transformed yeast cells, Postgrad. Med. J. 63 (suppl. 2):73–81 Roggenkamp, 1984, Biosynthesis and regulation of peroxysomal methanol oxidase from the methylotrophic yeast, Hansenula polymorpha, Mol.Gen.Genet., 194, 489, 10.1007/BF00425563 Roggenkamp, 1986, Transformation of the methylotrophic yeast Hansenula polymorpha by autonomous replication and integration vectors, Mol.Gen.Genet., 202, 302, 10.1007/BF00331655 Sierkstra, 1991, Optimisation of a host/vector system for heterologous gene expression by Hansenula polymorpha, Curr. Genet., 19, 81, 10.1007/BF00326287 Tschopp, 1987, High-level secretion of glycosylated invertase in the methylotrophic yeast, Pichia pastoris, Bio/Technology, 5, 1305, 10.1038/nbt1287-1305 Valenzuela, 1982, Synthesis and assembly of hepatitis B virus surface antigen particles in yeast, Nature, 298, 347, 10.1038/298347a0 Vedvick, 1991, High-level secretion of biologically active aprotinin from the yeast, Pichia pastoris, J. Industrial Microbiol., 7, 197, 10.1007/BF01575883 Waters, 1988, Prepro-α- factor has a cleavable signal sequence, J.Biol.Chem., 263, 6209, 10.1016/S0021-9258(18)68773-3 Wegner, 1990, Emerging applications of the methylotrophic yeasts, FEMS Microbiology reviews, 87, 279, 10.1111/j.1574-6968.1990.tb04925.x