High-dose aprotinin therapy: A review of the first five years' experience
Tóm tắt
Từ khóa
Tài liệu tham khảo
Royston, 1990, The serine antiprotease aprotinin (Trasylol): A novel approach to reducing postoperative bleeding, Blood Coag Fibrinol, 1, 55, 10.1097/00001721-199003000-00009
Royston, 1987, Effect of aprotinin on the need for blood transfusion after repeat open heart surgery, Lancet, 2, 1289, 10.1016/S0140-6736(87)91190-1
Fritz, 1983, Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organs, Arzneimittelforsch, 33, 479
Kraut, 1930, Über die Inaktivierung des Kallikreins, Hoppe-Seyler's Zeitschrift für Physiologische Chemie, 192, 1, 10.1515/bchm2.1930.192.1-3.1
Kunitz, 1936, Isolation from beef pancreas of crystalline trypsinogen, trypsin, atrypsin inhibitor, and an inhibitor trypsin compound, J Gen Physiol, 19, 991, 10.1085/jgp.19.6.991
Laskowski, 1980, Protein inhibitors of proteinases, Ann Rev Biochem, 49, 593, 10.1146/annurev.bi.49.070180.003113
Fritz, 1979, Immunofluorescent studies indicate that the basic trypsin—Kallikrein inhibitor of bovine-organs (Trasylol) originates from mast cells, Hoppe-Seyler's Z Physiol Chem, 360, 437, 10.1515/bchm2.1979.360.1.437
Dietl, 1975, Trypsin—Kallikrein isoenzyme K (type Kunitz) from snails (Helix pomatia): Purification and characterization, Eur J Biochem, 58, 453, 10.1111/j.1432-1033.1975.tb02392.x
Wunderer, 1976, Broad specifiity inhibitors from sea anemones, Methods Enzymol, 45, 881, 10.1016/S0076-6879(76)45082-6
Fioretti, 1987, Kunitz type inhibitors in human serum. Identification and characterization, J Biol Chem, 262, 3586, 10.1016/S0021-9258(18)61392-4
Fioretti, 1983, Heterogeneity of the basic pancreatic inhibitor (Kunitz) in various bovine organs, Eur J Biochem, 130, 13, 10.1111/j.1432-1033.1983.tb07110.x
Phillipe, 1978, Calculations and hypothetical considerations on the inhibition of plasmin and plasma kallikrein by Trasylol, vol 3, 291
Markwardt, 1977, Naturally occurring inhibitors of fibrinolysis, Handbook Exp Pharmacol, 46, 487
Taby, 1990, Inhibition of activated protein C by aprotinin and the use of the insolubilized inhibitor for its purification, Thrombosis Res, 59, 27, 10.1016/0049-3848(90)90268-H
España, 1989, Aprotinin (Trasylol) is a competitive inhibitor of activated protein C, Thrombosis Res, 56, 751, 10.1016/0049-3848(89)90292-2
Lottenberg, 1988, Aprotinin inhibits urokinase but not tissue—Type plasminogen activator, Thrombosis Res, 49, 549, 10.1016/0049-3848(88)90252-6
Puri, 1989, Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpain, Arch Biochem Biophys, 271, 356, 10.1016/0003-9861(89)90284-1
Murphy, 1987, Calcium-dependent cysteine protease activity in the sera of patients with thrombotic thrombocytopenic purpura, Blood, 70, 1683, 10.1182/blood.V70.5.1683.1683
Habermann, 1973, Das Verhalten des Trasylol im Organismus als Modell fuer die Pharmakokinetik basischer Polypeptide, Med Welt, 24, 1163
Fischer, 1985, Trasylol-Effeckte an der Neire-Temperatur und Dosisabhaengigkeit, 127
Royston, 1985, The effects of surgery with cardiopulmonary bypass on alveolar-capillary barrier function in man, Ann Thorac Surg, 40, 133, 10.1016/S0003-4975(10)60006-9
Royston, 1989, 113m Indium protein flux does not reflect degree or outcome in respiratory failure, Am Rev Respir Dis, 139, A380
Royston, 1986, Increased peroxide product generation associated with open heart surgery; evidence for free radical generation, J Thorac Cardiovasc Surg, 91, 759, 10.1016/S0022-5223(19)35998-7
Braude, 1986, Increased pulmonary transvascular protein flux after canine cardiopulmonary bypass. Association with lung neutrophil sequestration and tissue peroxidation, Am Rev Respir Dis, 134, 867, 10.1164/arrd.1986.134.5.867
Kirklin, 1983, Complement and the damaging effects of cardiopulmonary bypass, J Thorac Cardiovasc Surg, 86, 845, 10.1016/S0022-5223(19)39061-0
Clasen, 1987, Feasibility study of very high dose aprotinin in polytrauma patients, 175
van Oeveren, 1987, Effects of aprotinin on haemostatic mechanisms during cardiopulmonary bypass, Ann Thorac Surg, 44, 640, 10.1016/S0003-4975(10)62153-4
Bidstrup, 1989, Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol), J Thorac Cardiovasc Surg, 97, 364, 10.1016/S0022-5223(19)34573-8
Bidstrup, 1991, Aprotinin therapy in cardiac surgery: A report on use in 42 UK cardiac centres, Lancet
Goodnough, 1991, The variability of transfusion practice in coronary artery bypass surgery, JAMA, 265, 86, 10.1001/jama.1991.03460010086037
Russell, 1988, Homologous blood use and conservation techniques in cardiac surgery in the United Kingdom, Br Med J, 297, 1390, 10.1136/bmj.297.6660.1390
Jones, 1991, Coronary bypass surgery: Is the operation different today?, J Thorac Cardiovasc Surg, 101, 108, 10.1016/S0022-5223(19)36799-6
Lytle, 1987, Coronary reoperations: Results and determinants of early and late survival, J Thorac Cardiovasc Surg, 93, 874
Freidrich, 1989, Reduction of blood transfusion requirement in open heart surgery by administration of high dose aprotinin—Preliminary results, Thorac Cardiovasc Surgeon, 37, 89, 10.1055/s-2007-1013914
Dietrich, 1989, Reduction of homologous blood requirements in cardiac surgery by intraoperative aprotinin application: Clinical experience in 152 cardiac surgical patients, Thorac Cardiovasc Surg, 37, 29, 10.1055/s-2007-1013915
Alajmo, 1989, High-dose aprotinin: Hemostatic effects in open-heart operations, Ann Thorac Surg, 48, 536, 10.1016/S0003-4975(10)66857-9
Dietrich, 1990, Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization, Anesthesiology, 73, 1119, 10.1097/00000542-199012000-00009
Dietrich, 1990, Routine application of high-dose aprotinin in open heart surgery—A study in 1,784 patients, Anesthesiology, 73, A146, 10.1097/00000542-199009001-00145
Royston, 1990, Aprotinin in open heart surgery; Background and results in patients having aortocoronary bypass grafts, Perfusion, 5, 63, 10.1177/0267659190005001S10
Royston, 1991, Clinical effectiveness of aprotinin in heart surgery, 208
Von der Emde, 1991, Retransfusion of Postoperative Drainage Blood, 129
Chesbro, 1982, A platelet-inhibitory drug trial in coronary artery bypass operations: benefits of perioperative dipyridamole and aspirin therapy on early postoperative vein-graft patency, N Engl J Med, 307, 73, 10.1056/NEJM198207083070201
Ferraris, 1988, Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting, Ann Thorac Surg, 45, 71, 10.1016/S0003-4975(10)62401-0
Sethi, 1990, Implications of preoperative administration of aspirin in patients undergoing coronary artery bypass grafting, J Am Coll Cardiol, 15, 15, 10.1016/0735-1097(90)90168-O
Bashein, 1991, Preoperative aspirin therapy and reoperation for bleeding after coronary artery bypass surgery, Arch Int Med, 151, 89, 10.1001/archinte.1991.00400010105014
Ferraris, 1989, Predictors of excessive blood use after coronary artery bypass grafting, J Thorac Cardiovasc Surg, 98, 492, 10.1016/S0022-5223(19)34348-X
Gluszko, 1991, Invited letter concerning bleeding time test, J Thorac Cardiovasc Surg, 101, 173, 10.1016/S0022-5223(19)36815-1
Royston, 1989, Aprotinin reduces bleeding after open heart surgery in patients taking aspirin and those with renal failure, Anesthesiology, 71, A6, 10.1097/00000542-198909001-00006
Royston, 1990, Reduction of bleeding after open heart surgery with aprotinin (Trasylol): Beneficial effects in patients taking aspirin and in those with renal failure, 66
Bidstrup, 1990, Aprotinin in aspirin treated patients, Perfusion, 5, 77, 10.1177/0267659190005001S12
Tabuchi, 1991, Preserved hemostasis during the combined use of aprotinin and aspirin in CABG operations, 245
Gavaghan, 1991, Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery, Circulation, 83, 1526, 10.1161/01.CIR.83.5.1526
Popov-Cenic, 1985, Anlage and zusammenfassendes Ergebnis einer klinischen Doppelblindstudie bei aorto-koronaren Bypass-Operationen, 171
Murday, 1984, Sind postoperative Blutungeb in der Herzchirurgie durch behandlung mit Aprotinin bzw. C1 inhibitor vermeidbar?, Thorac Cardiovasc Surg, 44, 88
Elliot, 1990, Aprotinin in paediatric cardiac surgery, Perfusion, 5, 73, 10.1177/0267659190005001S11
Dawkins, 1985, Long term results, haemodynamics, and complications after combined heart-lung transplantation, Circulation, 71, 919, 10.1161/01.CIR.71.5.919
Novick, 1990, Reduction in bleeding after heart-lung transplantation: the importance of posterior mediastinal haemostasis, Chest, 98, 1383, 10.1378/chest.98.6.1383
Brier, 1990, Kinetics of aprotinin during open heart surgery, J Pharmacol Therap, 47, 183
Struck, 1990, Blood saving strategies in cardiac surgery, 16
Angelini, 1990, Unorthodox use of aprotinin to control life-threatening bleeding after cardiopulmonary bypass, Lancet, 1, 799, 10.1016/0140-6736(90)90922-R
Bidstrup, 1988, Effect of aprotinin on need for blood transfusions in patients with endocarditis having open heart surgery, Lancet, 1, 366, 10.1016/S0140-6736(88)91170-1
Koestering, 1978, Untersuchungen der Blutgerinnungsveraenderungen wahrend und nach Operationen mit Hilfe der Herz-Lungen — Maschine, Thoraxchirurge, 21, 534
Elliot, 1990, Perfusion for pediatric open heart surgery, Sem Thorac Cardiovasc Surg, 2, 332
van Oeveren, 1990, Aprotinin protects platelets against the initial effect of cardiopulmonary bypass, J Thorac Cardiovas Surg, 99, 788, 10.1016/S0022-5223(19)36893-X
Hannekum, 1985, Anlage und zussammenfassendes Ergebnis einer Klinischen Doppelblindstudie bei Operationen am offenen Herzen.Einfluss von Aprotinin auf Thrombozytensahl und -funktion, 222
Scott, 1991, The Edinburgh experience—Low dose Trasylol, 263
Fraedrich, 1991, Safety and risk/benefit assessment of aprotinin in primary CABG, 221
Blauhut, 1991, Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass, J Thorac Cardiovas Surg, 101, 958, 10.1016/S0022-5223(19)36611-5
Roth, 1991, Developing relations; Arterial platelet adhesion, Glycoprotein Ib, and leucine rich glycoproteins, Blood, 77, 5, 10.1182/blood.V77.1.5.5
Hennessy, 1977, Function of human platelets during extracorporeal circulation, Am J Physiol, 232, H622
Glusko, 1987, Fibrinogen receptors in platelet adhesion to surfaces of extracorporeal circuit, Am J Physiol, 252, H615
Salzman, 1963, Blood platelets and extracorporeal circulation, Transfusion, 3, 274, 10.1111/j.1537-2995.1963.tb04642.x
McKena, 1975, The hemostatic defect after open heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation, J Thorac Cardiovasc Surg, 70, 298
Cella, 1981, The release of platelet factor 4 and beta-thromboglobulin during extracorporeal circulation for open heart surgery, Eur J Clin Invest, 11, 165, 10.1111/j.1365-2362.1981.tb01836.x
Mezzano, 1986, Changes in platelet b thromboglobulin, fibrinogen, albumin, 5-hydroxytryptamine ATP and ADP during and after surgery with extracorporeal circulation in man, Am J Hematol, 22, 133, 10.1002/ajh.2830220204
Watkins, 1982, Thromboxane and prostacyclin changes during cardiopulmonary bypass with pulsatile perfusion, J Thorac Cardiovasc Surg, 84, 250, 10.1016/S0022-5223(19)39041-5
Ditter, 1983, Effects of prostacyclin during cardiopulmonary bypass in man on plasma levels of beta-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1 alpha and heparin, Thromb Res, 32, 393, 10.1016/0049-3848(83)90092-0
Harker, 1980, Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass; aquired transient platelet defect associated with selective alpha granule release, Blood, 56, 824
Musial, 1985, Loss of fibrinogen receptors from the platelet surface during stimulated extracorporeal circulation, J Lab Clin Med, 105, 514
Zilla, 1989, Blood platelets in cardiopulmonary bypass operations, J Thorac Cardiovasc Surg, 97, 379, 10.1016/S0022-5223(19)34575-1
George, 1986, Platelet surface glycoproteins; Studies on resting and activated platelets and platelet membrane microparticles in normal subjects, and observations in patients during adult respiratory distress syndrome and cardiac surgery, J Clin Invest, 78, 340, 10.1172/JCI112582
George, 1984, Molecular defects in interactions of platelets with the vessel wall, N Engl J Med, 311, 1084, 10.1056/NEJM198410253111705
Levine, 1977, Development of a radioimmunoassay for human platelet factor 4, Thromb Res, 11, 673, 10.1016/0049-3848(77)90025-1
Abrams, 1987, Direct detection of activated platelets and platelet-derived microparticles in humans, Blood, 75, 128, 10.1182/blood.V75.1.128.128
Schulman, 1991, Heparin, DDAVP and the Bleeding Time, Thomb Haem, 65, 242
Gimple, 1989, Correlation between template bleeding times and spontaneous bleeding during treatment of acute myocardial infarction with recombinant tissue type plasminogen activator, Circulation, 80, 581, 10.1161/01.CIR.80.3.581
Bick, 1985, Hemostasis defects associated with cardiac surgery, prosthetic devices, and other extracorporeal cicuits, Semin Thromb Hemost, 11, 249, 10.1055/s-2007-1004381
Mammen, 1985, Hemostasis changes during cardiopulmonary bypass surgery, Semin Thromb Hemost, 11, 281, 10.1055/s-2007-1004382
Stibbe, 1984, Enhanced fibrinolysic activity during cardiopulmonary bypass in open heart surgery in man is caused by extrinsic (tissue type) plasminogen activator, Eur J Clin Invest, 14, 375, 10.1111/j.1365-2362.1984.tb01198.x
Tanaka, 1989, Alterations in coagulation and fibrinolysis associated with cardiopulmonary bypassnduring open heart surgery, J Cardiothorac Anesth, 3, 181, 10.1016/S0888-6296(89)92642-2
Holloway, 1988, Decreased platelet numbers and function and increased fibrinolysis contribute to postoperative bleeding in cardiopulmonary bypass patients, Thromb Haemost, 59, 62, 10.1055/s-0038-1646770
Van Riper, 1990, Is the thromboelastograph a clinically useful predictor of blood loss after bypass?, Anesthesiology, 733A, A1206
Gram, 1990, Enhanced effective fibrinolysis following the neutralization of heparin in open heart surgery increases the risk of post-surgical bleeding, Thromb Haemost, 63, 241, 10.1055/s-0038-1645202
Marengo-Rowe, 1988, Fibrinolysis: A frequent cause of bleeding, 41
Spiess, 1989, Thromboelastographic diagnosis of coagulopathies in patients undergoing cardiopulmonary bypass, Anesth Analg, 68, 53
Horrow, 1990, Prophylactic tranexamic acid decreases bleeding after cardiac operations, J Thorac Cardiovasc Surg, 99, 70, 10.1016/S0022-5223(19)35634-X
Van der Salm, 1988, The role of epsilon aminoeaproic acid in reducing bleeding after cardiac operations; a double blind randoomized study, J Thorac Cardiovasc Surg, 96, 538, 10.1016/S0022-5223(19)35778-2
Fish, 1986, A prospective, randomized study of the effects of prostacyclin on platelets and blood loss during coronary bypass operations, J Thorac Cardiovasc Surg, 91, 436, 10.1016/S0022-5223(19)36060-X
Teoh, 1988, Dipyridamole preserved platelets and reduced blood loss after cardiopulmonary bypass, J Thorac Cardiovasc Surg, 96, 332, 10.1016/S0022-5223(19)35281-X
Harke, 1980, Aprotinin-ACD Blut. 1. Experimentelle Untersuchungen über den Einfluss von Aprotinin auf die plasmatische und thrombozytare, Gerinnun Anesthetist, 29, 266
Aoki, 1978, Inhibition of platelet aggregation by protease inhibitors. Possible involvement of proteases in platelet aggregation, Blood, 52, 1, 10.1182/blood.V52.1.1.1
Ketterl, 1980, Wirkung von Aprotinin auf die Thrombozytenfunktion währendHüft-Totalendoprosthesenoperation, Med Welt, 31, 1239
Ketterl, 1982, Zur Wirkung des natürlichen Proteinaseninhibitors Aprotinin auf die Plättchenfunktion beim alloarthroplastischen Hüftgelenkersatz, Med Welt, 33, 480
Harke, 1982, Aprotinin ACD Blut II: Der Einfluss von Aprotinin auf die Freisetzung zellulärere Medioraten un Enzyme im Konservenblut, Anaesthetist, 31, 165
Bode, 1989, The use of thrombin inhibitors and aprotinin in the preservation of platelets stored for transfusion, J Lab Clin Med, 113, 753
Okumura, 1976, Platelet glycocalicin 1: Orientation of glyoproteins of the human platelet surface, J Biol Chem, 251, 5944, 10.1016/S0021-9258(17)33043-0
Adelman, 1985, Plasmin effect on platelet glycoprotein 1b-von Willebrand factor interactions, Blood, 65, 32, 10.1182/blood.V65.1.32.32
Bode, 1990, Effect of platelet activation inhibitors on the loss of glycoprotein Ib during storage of platelet concentrates, J Lab Clin Med, 115, 669
Commin, 1990, Mechanisms of bleeding induced by aprotinin during cardiopulmonary bypass: A controlled study, Anesthesiology, 73, A1205, 10.1097/00000542-199009001-01205
Mohr, 1986, Effect of cardiac operations on platelets, J Thorac Cardiovas Surg, 92, 434, 10.1016/S0022-5223(19)35797-6
Lazenby, 1990, Treatment with desmopressin acetate in routine coronary artery bypass surgery to improve postoperative haemostasis, Circulation, 82, 413
Cramer, 1991, Differential redistribution of platelet glycoproteins Ib and IIb/IIIa after plasmin stimulation, Blood, 77, 694, 10.1182/blood.V77.4.694.694
Michelson, 1988, Platelet storage results in a redistribution of glycoprotein Ib molecules; evidence for a large intraplatelet pool of glycoprotein IB, J Clin Invest, 81, 1734, 10.1172/JCI113513
Colman, 1987, Initiation of blood coagulation at artificial surfaces, Ann NY Acad Sci, 56, 253, 10.1111/j.1749-6632.1987.tb33046.x
Miles, 1986, Plasminogen interacts with human platelets through two distinct mechanisms, J Clin Invest, 77, 2001, 10.1172/JCI112529
Miles, 1985, Binding and activation of plasminogen of the platelet surface, J Biol Chem, 260, 4303, 10.1016/S0021-9258(18)89264-X
Parf, 1989, Demonstration of single chain urokinase type plasminogen activator on human platelet membrane, Blood, 73, 1421, 10.1182/blood.V73.6.1421.1421
Kluft, 1987, Role of the contactsystem in fibrinolysis, Semin Thromb Haemost, 13, 50, 10.1055/s-2007-1003475
Kowalski, 1963, Influence of fibrinogen degradation products (FDP) on platelet aggregation, adhesiveness and viscous metamorphosis, Thromb Diath Haemorrh, 10, 406
de Bono, 1991, Differential effects of aprotinin and tranexamic acid on cerebral bleeding and cutaneous bleeding time during rt-PA infusion, Thromb Res, 61, 159, 10.1016/0049-3848(91)90243-P
Kornecki, 1986, Exposure of fibrinogen receptors in human platelets by surface proteolysis with elastase, J Clin Invest, 77, 750, 10.1172/JCI112370
Royston, 1988, Free radicals; formation, function and potential relevance in anaesthesia, Anaesthesia, 43, 315, 10.1111/j.1365-2044.1988.tb08984.x
Henson, 1970, Mechanisms of release of constituents from rabbit platelets by antigen-antibody complexes: II. Interactions between platelets and neutrophils, J Immunol, X, 490, 10.4049/jimmunol.105.2.490
Clark, 1980, Neutrophil platelet interactions are mediated by myeloperoxidase or hydrogen peroxide, J Immunol, 124, 399, 10.4049/jimmunol.124.1.399
Wachtfogel, 1983, Human plasma kallikrein releases neutrophil elastase during blood coagulation, J Clin Invest, 72, 1672, 10.1172/JCI111126
Zimmerli, 1989, Purified human plasma kallikrein does not stimulate but primes neutrophils for superoxide production, Thromb Haemost, 62, 1121, 10.1055/s-0038-1647130
Francis JL, Lord RAM, Roath OS: The effect of aprotinin on haemostasis and white cell function in aortic surgery. Thromb Haemost (In press)
Royston, 1987, Platelet preservation reduces production of lipid peroxidation during cardiopulmonary bypass in humans, Am Rev Resp Dis, 135, A13
Ruggerio, 1986, Protease and cyclooxygenase inhibitors synergistically prevent activation of human platelets, 83, 3456
Ruggerio, 1987, Antipain and leupeptin in combination with aspirin or indomethacin synergistically inhibit platelet activation by thrombin and trypsin, Adv Prost Thrombox Leukotr Res, 17A, 563
Royston, 1991, Effects of aprotinin on the whole blood clot lysis associated with open heart surgery, Blood Coag Fibrinol
Spiess, 1987, Thromboelastography as an indicator of post-cardiopulmonary bypass coagulopathies, J Clin Monit, 3, 25, 10.1007/BF00770880
Kang, 1987, Epsilon amino caproic acid for the treatment of fibrinolysis during liver transplantation, Anesthesiology, 66, 766, 10.1097/00000542-198706000-00010
Clozel, 1990, Aprotinin: An antidote for recombinant tissue-type plasminogen activator (rt-PA) active in vivo, J Am Coll Cardiol, 16, 507, 10.1016/0735-1097(90)90612-S
Wiman, 1980, On the reaction of plasmin or plasminstreptokinase complex with aprotinin or alpha 2 antiplasmin, Thromb Res, 17, 143, 10.1016/0049-3848(80)90302-3
Overlack, 1981, Evidence for participation of kinins in the antihypertensive effect of converting enzyme inhibition, Klin Wochenschr, 59, 69, 10.1007/BF01477285
Kurusz, 1983, Filtration during open heart surgery: Devices, techniques, opinions, and complications, 4, 123
Royston, 1989, Reduced blood loss after open heart surgery with aprotinin is associated with an increase in the activated clotting time (ACT), J Cardiothorac Anesth, 3, 80, 10.1016/0888-6296(89)90823-5
de Smet, 1990, Increased anticoagulation during cardiopulmonary bypass by aprotinin, J Thorac Cardiovasc Surg, 100, 520, 10.1016/S0022-5223(19)35496-0
Royston D: A prolonged activated clotting time is an unreliable indicator of thrombus formation during aprotinin therapy. J Thorac Cardiovasc Surg (In press)
Pratt, 1991, Antithrombin: Structure and function, Semin Hematol, 28, 3
Ross, 1991, Aprotinin; Effect on redo surgery, 260
Dietrich, 1990, High-dose aprotinin in cardiac surgery. Old drug-new aspects of homologous blood requirement, 76
Henderson, 1989, Antiplatelet or anticoagulant therapy after coronary artery bypass surgery: A meta-analysis of clinical trials, Ann Int Med, 111, 743, 10.7326/0003-4819-111-9-743
Royston BD, Royston D, Pearson JD: Aprotinin inhibits platelet adhesion to thrombin stimulated human endothelial cells. Thromb Haemost (In press)
Gould RJ, Gan Z-R, Polokoff MA, et al: Disintegrins; A family of integrin inhibitory proteins from viper venoms. Faseb J (In press)
Ohno, 1981, Foy: [Ethyl-p (guanidinohexanyloxy) benzoate] methylsulfonate as a serine protease inhibitor. II In Vivo effect on coagulo-fibrinolytic system in comparison with heparin and aprotinin, Thromb Res, 24, 445, 10.1016/0049-3848(81)90078-5
Taenaka, 1982, New approach to regional anticoagulation in haemodialysis, Crit Care Med, 10, 773, 10.1097/00003246-198211000-00017
Solbereg, 1991, Lack of ability to synthesize tissue factor by endothelial cells from intact saphenous vein, Blood Coag Fibrinol
Bidstrup BP: Aprotinin therapy has no effects on early graft patency. Lancet (In press)
Harke, 1989, Clinical relevance of the membrane protective action of aprotinin on the intraoperative histamine liberation, Prog Clin Biol Res, 308, 959
Weiss, 1989, Evaluation of allergic drug reactions in the perioperative period, Anesthesiology, 71, 483, 10.1097/00000542-198910000-00001