HOXA9 thúc đẩy cam kết tạo huyết của tế bào gốc phôi người

Blood - Tập 124 - Trang 3065-3075 - 2014
Veronica Ramos-Mejía1, Oscar Navarro-Montero1, Verónica Ayllón1, Clara Bueno2, Tamara Romero1, Pedro J. Real1, Pablo Menendez2,3
1Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain;
2Josep Carreras Leukemia Research Institute, Cell Therapy Program, School of Medicine, University of Barcelona, Barcelona, Spain; and
3Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain

Tóm tắt

Những điểm chính HOXA9 tương đồng với phát triển máu, nhưng bị giới hạn ở HEP và giảm dần khi chúng phân hóa thành các tế bào máu. Các xét nghiệm chức năng tiết lộ cách HOXA9 tăng cường sự hình thành máu bằng cách thúc đẩy cam kết của HEP đối với các tế bào CD45+ có tiềm năng clonogenic cao hơn.

Từ khóa


Tài liệu tham khảo

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