HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase

PLoS Pathogens - Tập 3 Số 7 - Trang e85
Jean-Philippe Belzile1, Ghislaine Duisit2, Nicole Rougeau1, Johanne Mercier1, Andrés Finzi1, Éric A. Cohen2,1
1Laboratory of Human Retrovirology, Institut de recherches cliniques de Montréal, Montreal, Quebec, Canada
2Department of Microbiology and Immunology, Université de Montréal, Montreal, Quebec, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

2005, The Vpr protein from HIV-1: Distinct roles along the viral life cycle., Retrovirology, 2, 11, 10.1186/1742-4690-2-11

2005, The role of Vpr in HIV-1 pathogenesis., Curr HIV Res, 3, 43, 10.2174/1570162052772988

1995, The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle., J Virol, 69, 6304, 10.1128/JVI.69.10.6304-6313.1995

1995, Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity., J Virol, 69, 6705, 10.1128/JVI.69.11.6705-6711.1995

1995, The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection., J Virol, 69, 882, 10.1128/JVI.69.2.882-888.1995

1995, Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B., J Virol, 69, 6859, 10.1128/JVI.69.11.6859-6864.1995

1996, Vpr-induced cell cycle arrest is conserved among primate lentiviruses., J Virol, 70, 2516, 10.1128/JVI.70.4.2516-2524.1996

1998, HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo., Nat Med, 4, 65, 10.1038/nm0198-065

2006, HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT., PLoS Pathog, 2

2001, Cell cycle checkpoint signaling through the ATM and ATR kinases., Genes Dev, 15, 2177, 10.1101/gad.914401

2006, DNA damage checkpoints in mammals., Mutagenesis, 21, 3, 10.1093/mutage/gei063

2004, Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints., Annu Rev Biochem, 73, 39, 10.1146/annurev.biochem.73.011303.073723

2004, The DNA damage response: Sensing and signaling., Curr Opin Cell Biol, 16, 629, 10.1016/j.ceb.2004.09.005

2003, Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R., J Biol Chem, 278, 25879, 10.1074/jbc.M303948200

2005, Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo., J Virol, 79, 15443, 10.1128/JVI.79.24.15443-15451.2005

2004, Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation., Mol Cell Biol, 24, 9286, 10.1128/MCB.24.21.9286-9294.2004

2006, Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo., J Virol, 80, 10407, 10.1128/JVI.01212-06

2006, HIV-1 Vpr induces DNA double-strand breaks., Cancer Res, 66, 627, 10.1158/0008-5472.CAN-05-3144

2001, Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr., Science, 294, 1105, 10.1126/science.1063957

2006, A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1., Mol Cell, 23, 709, 10.1016/j.molcel.2006.08.010

2001, Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein−protein interaction with a novel human cytoplasmic protein VprBP., Gene, 263, 131, 10.1016/S0378-1119(00)00583-7

1994, Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein., J Biol Chem, 269, 15577, 10.1016/S0021-9258(17)40719-8

1995, Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr., J Virol, 69, 7909, 10.1128/JVI.69.12.7909-7916.1995

2001, Human DNA repair genes., Science, 291, 1284, 10.1126/science.1056154

1999, Characterization of DNA recognition by the human UV-damaged DNA-binding protein., J Biol Chem, 274, 20027, 10.1074/jbc.274.28.20027

2003, The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage., Cell, 113, 357, 10.1016/S0092-8674(03)00316-7

2006, L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage., Cell Cycle, 5, 1675, 10.4161/cc.5.15.3149

2006, DDB1 maintains genome integrity through regulation of Cdt1., Mol Cell Biol, 26, 7977, 10.1128/MCB.00819-06

2002, ATR regulates fragile site stability., Cell, 111, 779, 10.1016/S0092-8674(02)01113-3

2002, Hypoxia links ATR and p53 through replication arrest., Mol Cell Biol, 22, 1834, 10.1128/MCB.22.6.1834-1843.2002

2001, ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation., Proc Natl Acad Sci U S A, 98, 9092, 10.1073/pnas.161281798

1998, Human immunodeficiency virus type 1 vpr protein transactivation function: Mechanism and identification of domains involved., J Mol Biol, 284, 915, 10.1006/jmbi.1998.2206

2000, Phosphorylation of human immunodeficiency virus type 1 Vpr regulates cell cycle arrest., J Virol, 74, 6520, 10.1128/JVI.74.14.6520-6527.2000

2000, The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 in vivo mutation rate., J Virol, 74, 7039, 10.1128/JVI.74.15.7039-7047.2000

2006, Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery., Nature, 443, 590, 10.1038/nature05175

2006, DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases., Genes Dev, 20, 2949, 10.1101/gad.1483206

2006, CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation., Nat Cell Biol, 8, 1277, 10.1038/ncb1490

2006, The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites., Proc Natl Acad Sci U S A, 103, 2588, 10.1073/pnas.0511160103

2006, Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage., Mol Cell, 22, 383, 10.1016/j.molcel.2006.03.035

2005, UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex., Cell, 121, 387, 10.1016/j.cell.2005.02.035

2004, Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase., Science, 303, 1371, 10.1126/science.1093549

2005, Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death., J Virol, 79, 4238, 10.1128/JVI.79.7.4238-4245.2005

2003, Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities., J Virol, 77, 6274, 10.1128/JVI.77.11.6274-6283.2003

2002, Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2., J Biol Chem, 277, 38847, 10.1074/jbc.M205722200

2005, Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1., J Virol, 79, 13434, 10.1128/JVI.79.21.13434-13441.2005

2002, The p127 subunit (DDB1) of the UV−DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5., J Virol, 76, 11379, 10.1128/JVI.76.22.11379-11386.2002

2005, Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases., J Virol, 79, 10978, 10.1128/JVI.79.17.10978-10987.2005

1998, HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle., Proc Natl Acad Sci U S A, 95, 3419, 10.1073/pnas.95.7.3419

2006, Structure of DDB1 in complex with a paramyxovirus V protein: Viral hijack of a propeller cluster in ubiquitin ligase., Cell, 124, 105, 10.1016/j.cell.2005.10.033

1995, A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects., Proc Natl Acad Sci U S A, 92, 2770, 10.1073/pnas.92.7.2770

1997, Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest., J Virol, 71, 4842, 10.1128/JVI.71.6.4842-4846.1997

1997, Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr., J Virol, 71, 6339, 10.1128/JVI.71.9.6339-6347.1997

2004, Recent advances in the understanding of HIV-1 Vpu accessory protein functions., Curr Drug Targets Immune Endocr Metabol Disord, 4, 297, 10.2174/1568008043339695

2007, HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase., Cell Cycle, 6, 182, 10.4161/cc.6.2.3732

2007, HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1., Proc Natl Acad Sci U S A, 104, 4130, 10.1073/pnas.0610167104

1998, Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells., J Virol, 72, 4686, 10.1128/JVI.72.6.4686-4693.1998

1990, Identification of HIV-1 vpr product and function., J Acquir Immune Defic Syndr, 3, 11

2001, The tandem affinity purification (TAP) method: A general procedure of protein complex purification., Methods, 24, 218, 10.1006/meth.2001.1183

1999, Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor., J Biol Chem, 274, 9083, 10.1074/jbc.274.13.9083

2003, Vpu exerts a positive effect on HIV-1 infectivity by down-modulating CD4 receptor molecules at the surface of HIV-1−producing cells., J Biol Chem, 278, 28346, 10.1074/jbc.M300327200

1999, Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors., J Virol, 73, 2886, 10.1128/JVI.73.4.2886-2892.1999

2002, Human immunodeficiency virus type 1 Vpr protein does not modulate surface expression of the CD4 receptor., J Virol, 76, 4125, 10.1128/JVI.76.8.4125-4130.2002