Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver

Molecular Metabolism - Tập 11 - Trang 113-128 - 2018
Arne Hinrichs1,2, Barbara Kessler1,2, Mayuko Kurome1,2,3, Andreas Blutke4, Elisabeth Kemter1,2, Maren Bernau5, Armin M. Scholz5, Birgit Rathkolb1,6, Simone Renner1,2,6, Sebastian Bultmann7, Heinrich Leonhardt7, Martin Hrabĕ de Angelis6,8, Hiroshi Nagashima3, Andreas Hoeflich9, Werner F. Blum10, Martin Bidlingmaier11, Rüdiger Wanke4, Maik Dahlhoff1,2, Eckhard Wolf1,2,3,6,12
1Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany
2Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, Hackerstr. 27, 85764 Oberschleißheim, Germany
3Meiji University International Institute for Bio-Resource Research, 1-1-1 Higashimita, Tama, Kawasaki, 214-8571, Japan
4Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, Veterinärstr. 13, 80539 Munich, Germany
5Livestock Center of the Veterinary Faculty, LMU Munich, St.-Hubertus-Str. 12, 85764 Oberschleißheim, Germany
6German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
7Human Biology and Bioimaging, Faculty of Biology, Biocenter, LMU Munich, Großhaderner Str. 2, 82152 Planegg-Martinsried, Germany
8Institute of Experimental Genetics, Helmholtz Zentrum München, and Chair of Experimental Genetics, Technical University of Munich, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
9Cell Signaling Unit, Institute of Genome Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
10University Children`s Hospital, University of Giessen, Feulgenstr.12, 35392 Gießen, Germany
11Endocrine Laboratory, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstr. 1, 80336 Munich, Germany
12Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany

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