Granzyme B is a novel interleukin-18 converting enzyme

Nakanishi, 2001, Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu, Cytokine Growth Factor Rev, 12, 53, 10.1016/S1359-6101(00)00015-0

Nakanishi, 2001, Interleukin-18 regulates both Th1 and Th2 responses, Annu Rev Immunol, 19, 423, 10.1146/annurev.immunol.19.1.423

Ghayur, 1997, Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production, Nature, 386, 619, 10.1038/386619a0

Gu, 1997, Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme, Science, 275, 206, 10.1126/science.275.5297.206

Gaggero, 2004, A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing, Oncogene, 23, 7552, 10.1038/sj.onc.1208036

Omoto, 2006, Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment, J Immunol, 177, 8315, 10.4049/jimmunol.177.12.8315

Harris, 1998, Definition and redesign of the extended substrate specificity of granzyme B, J Biol Chem, 273, 27364, 10.1074/jbc.273.42.27364

Waugh, 2000, The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity, Nat Struct Biol, 7, 762, 10.1038/78992

Jenne, 1988, Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation, Immunol Rev, 103, 53, 10.1111/j.1600-065X.1988.tb00749.x

Berke, 1995, Unlocking the secrets of CTL and NK cells, Immunol Today, 16, 343, 10.1016/0167-5699(95)80152-9

Trapani, 2002, Functional significance of the perforin/granzyme cell death pathway, Nat Rev Immunol, 2, 735, 10.1038/nri911

Froelich, 1996, Granzyme B/perforin-mediated apoptosis of Jurkat cells results in cleavage of poly(ADP-ribose) polymerase to the 89-kDa apoptotic fragment and less abundant 64-kDa fragment, Biochem Biophys Res Commun, 227, 658, 10.1006/bbrc.1996.1565

Song, 1996, DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis, EMBO J, 15, 3238, 10.1002/j.1460-2075.1996.tb00688.x

Andrade, 1998, Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis, Immunity, 8, 451, 10.1016/S1074-7613(00)80550-6

Duriez, 1997, Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death, Biochem Cell Biol, 75, 337, 10.1139/o97-043

Graubert, 1996, The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection, Blood, 87, 1232, 10.1182/blood.V87.4.1232.bloodjournal8741232

Park, 2004, Increased expression of IL-18 in cutaneous graft-versus-host disease, Immunol Lett, 95, 57, 10.1016/j.imlet.2004.06.011

Yawalkar, 2001, Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis, Br J Dermatol, 144, 1133, 10.1046/j.1365-2133.2001.04222.x

Yawalkar, 2001, A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B, Am J Pathol, 158, 803, 10.1016/S0002-9440(10)64027-8

Muller, 1998, Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease, Am J Pathol, 152, 261

Leon, 2009, High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD, Mediat Inflamm, 2009, 580450, 10.1155/2009/580450

Homs, 2009, Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy, Am J Transplant, 9, 1230, 10.1111/j.1600-6143.2009.02596.x

Striz, 2005, Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft, Immunol Lett, 99, 30, 10.1016/j.imlet.2005.01.010

Spaeny-Dekking, 1998, Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo, J Immunol, 160, 3610, 10.4049/jimmunol.160.7.3610

Poe, 1991, Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity, J Biol Chem, 266, 98, 10.1016/S0021-9258(18)52407-8

Talanian, 1996, Stability and oligomeric equilibria of refolded interleukin-1beta converting enzyme, J Biol Chem, 271, 21853, 10.1074/jbc.271.36.21853

Fynbo, 2005, Characterization of a recombinant granzyme B derivative as a “restriction” protease, Protein Expr Purif, 39, 209, 10.1016/j.pep.2004.10.010

Yamin, 1996, Activation of the native 45-kDa precursor form of interleukin-1-converting enzyme, J Biol Chem, 271, 13273, 10.1074/jbc.271.22.13273

Thornberry, 1997, A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis, J Biol Chem, 272, 17907, 10.1074/jbc.272.29.17907

Backes, 2005, GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences, Nucleic Acids Res, 33, W208, 10.1093/nar/gki433

Konishi, 2002, IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions, Proc Natl Acad Sci USA, 99, 11340, 10.1073/pnas.152337799

Yamanaka, 2000, Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18, J Immunol, 165, 997, 10.4049/jimmunol.165.2.997

Yoshimoto, 2000, IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6, Nat Immunol, 1, 132, 10.1038/77811

Mizutani, 1991, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase, J Exp Med, 174, 821, 10.1084/jem.174.4.821

Mee, 2000, Human keratinocytes constitutively produce but do not process interleukin-18, Br J Dermatol, 143, 330, 10.1046/j.1365-2133.2000.03759.x

Nguyen, 2008, Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma, Eur J Immunol, 38, 2034, 10.1002/eji.200738082

Reading, 2007, IL-18, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type 1 infection, J Immunol, 179, 3214, 10.4049/jimmunol.179.5.3214

Hyodo, 1999, IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor, J Immunol, 162, 1662, 10.4049/jimmunol.162.3.1662

Inachi, 1997, Epidermal apoptotic cell death in erythema multiforme and Stevens–Johnson syndrome. Contribution of perforin-positive cell infiltration, Arch Dermatol, 133, 845, 10.1001/archderm.133.7.845

Lauw, 2000, Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria, J Infect Dis, 182, 206, 10.1086/315642

Tak, 1999, The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA), Clin Exp Immunol, 116, 366, 10.1046/j.1365-2249.1999.00881.x

Fujino, 2003, CrmA gene expression protects mice against concanavalin-A-induced hepatitis by inhibiting IL-18 secretion and hepatocyte apoptosis, Gene Ther, 10, 1781, 10.1038/sj.gt.3302067

Miura, 2004, Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand, Biol Blood Marrow Transplant, 10, 156, 10.1016/j.bbmt.2003.10.005

Oberbauer, 2008, Biomarkers—a potential route for improved diagnosis and management of ongoing renal damage, Transplant Proc, 40, S44, 10.1016/j.transproceed.2008.10.005

Ayello, 2009, Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy, Exp Hematol, 37, 1216, 10.1016/j.exphem.2009.07.009

Darmon, 1994, The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme, J Biol Chem, 269, 32043, 10.1016/S0021-9258(18)31596-5

Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, 26, 239, 10.1038/bjc.1972.33