Gonadotropin-Releasing Hormone: One Polypeptide Regulates Secretion of Luteinizing and Follicle-Stimulating Hormones

American Association for the Advancement of Science (AAAS) - Tập 173 Số 4001 - Trang 1036-1038 - 1971
Andrew V. Schally1, Akira Arimura1, A J Kastin1, H. Matsuo1, Yukihiro Baba1, Tommie W. Redding1, R.M.G. Nair1, Luciano Debéljuk1, W. F. White2
1Veterans Administration Hospital and Tulanie University School of Medicine, New Orleans, Louisiana 70140
2Abbott Laboratories, North Chicago, Illinois

Tóm tắt

A polypeptide isolated from porcine hypothalami stimulates the release of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species. This polypeptide has been structurally identified as (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH 2 and synthesized. The natural and synthetic materials share biological properties. It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone.

Từ khóa


Tài liệu tham khảo

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