Ghrelin and the short- and long-term regulation of appetite and body weight
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Ogden, 2006, Prevalence of overweight and obesity in the United States, 1999–2004, JAMA, 295, 1549, 10.1001/jama.295.13.1549
Safer, 1991, Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective, South Med J, 84, 1470, 10.1097/00007611-199112000-00015
Cummings, 2003, Genetics and pathophysiology of human obesity, Annu Rev Med, 54, 453, 10.1146/annurev.med.54.101601.152403
Kojima, 1999, Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, 402, 656, 10.1038/45230
Wren, 2000, The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion, Endocrinology, 141, 4325, 10.1210/en.141.11.4325
Nakazato, 2001, A role for ghrelin in the central regulation of feeding, Nature, 409, 194, 10.1038/35051587
Asakawa, 2001, Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin, Gastroenterology, 120, 337, 10.1053/gast.2001.22158
Wren, 2001, Ghrelin enhances appetite and increases food intake in humans, J Clin Endocrinol Metab, 86, 5992, 10.1210/jc.86.12.5992
Neary, 2004, Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial, J Clin Endocrinol Metab, 89, 2832, 10.1210/jc.2003-031768
Schmid, 2005, Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls, Neuropsychopharmacology, 30, 1187, 10.1038/sj.npp.1300670
Laferrere, 2005, Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men, J Clin Endocrinol Metab, 90, 611, 10.1210/jc.2004-1719
Druce, 2005, Ghrelin increases food intake in obese as well as lean subjects, Int J Obes (Lond), 29, 1130, 10.1038/sj.ijo.0803001
Wynne, 2005, Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial, J Am Soc Nephrol, 16, 2111, 10.1681/ASN.2005010039
Wren, 2001, Ghrelin causes hyperphagia and obesity in rats, Diabetes, 50, 2540, 10.2337/diabetes.50.11.2540
Xie, 2004, Ghrelin and truncated ghrelin variant plasmid vectors administration into skeletal muscle augments long-term growth in rats, Domest Anim Endocrinol, 27, 155, 10.1016/j.domaniend.2004.03.005
Nagaya, 2004, Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure, Circulation, 110, 3674, 10.1161/01.CIR.0000149746.62908.BB
Nagaya, 2005, Treatment of cachexia with ghrelin in patients with COPD, Chest, 128, 1187, 10.1378/chest.128.3.1187
Howard, 1996, A receptor in pituitary and hypothalamus that functions in growth hormone release, Science, 273, 974, 10.1126/science.273.5277.974
Guan, 1997, Distribution of mRNA encoding the GHS receptor in brain and peripheral tissues, Mol Brain Res, 48, 23, 10.1016/S0169-328X(97)00071-5
Gnanapavan, 2002, The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans, J Clin Endocrinol Metab, 87, 2988, 10.1210/jc.87.6.2988
Sun, 2004, Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor, Proc Natl Acad Sci U S A, 101, 4679, 10.1073/pnas.0305930101
Zigman, 2006, Expression of ghrelin receptor mRNA in the rat and the mouse brain, J Comp Neurol, 494, 528, 10.1002/cne.20823
van der Lely, 2004, Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin, Endocr Rev, 25, 426, 10.1210/er.2002-0029
Halem, 2004, Novel analogs of ghrelin: physiological and clinical implications, Eur J Endocrinol, 151, S71, 10.1530/eje.0.151S071
Nishi, 2005, Ingested medium-chain fatty acids are directly utilized for the acyl-modification of ghrelin, Endocrinology, 146, 2255, 10.1210/en.2004-0695
Cummings, 2005, Ghrelin and energy balance: focus on current controversies, Curr Drug Targets, 6, 153, 10.2174/1389450053174569
Chen, 2004, Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein, Endocrinology, 145, 2607, 10.1210/en.2003-1596
Davenport, 2005, International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function, Pharmacol Rev, 57, 541, 10.1124/pr.57.4.1
Malagon, 2003, Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes, Endocrinology, 144, 5372, 10.1210/en.2003-0723
Wettschureck, 2005, Loss of gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice, Mol Cell Biol, 25, 1942, 10.1128/MCB.25.5.1942-1948.2005
Kohno, 2003, Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin, Diabetes, 52, 948, 10.2337/diabetes.52.4.948
Garcia, 2001, Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor, Mol Endocrinol, 15, 1484, 10.1210/me.15.9.1484
Holst, 2003, High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist, Mol Endocrinol, 17, 2201, 10.1210/me.2003-0069
Holst, 2004, Common structural basis for constitutive activity of the ghrelin receptor family, J Biol Chem, 10.1074/jbc.M407676200
Bednarek, 2000, Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a, J Med Chem, 43, 4370, 10.1021/jm0001727
Matsumoto, 2001, Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides, Biochem Biophys Res Commun, 287, 142, 10.1006/bbrc.2001.5553
Aydin, 2006, Ghrelin in plants: what is the function of an appetite hormone in plants?, Peptides, 27, 1597, 10.1016/j.peptides.2006.01.005
Palyha, 2000, Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans, Mol Endocrinol, 14, 160, 10.1210/me.14.1.160
Riley, 2005, Long-term treatment of ghrelin stimulates feeding, fat deposition, and alters the GH/IGF-I axis in the tilapia, Oreochromis mossambicus, Gen Comp Endocrinol, 142, 234, 10.1016/j.ygcen.2005.01.009
Canosa, 2005, Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide, Am J Physiol Regul Integr Comp Physiol, 289, R125, 10.1152/ajpregu.00759.2004
Volkoff, 2005, Neuropeptides and the control of food intake in fish, Gen Comp Endocrinol, 142, 3, 10.1016/j.ygcen.2004.11.001
Tanaka-Shintani, 2005, Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells, J Gastroenterol, 40, 345, 10.1007/s00535-004-1550-3
Date, 2000, Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans, Endocrinology, 141, 4255, 10.1210/en.141.11.4255
Ariyasu, 2001, Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans, J Clin Endocrinol Metab, 86, 4753, 10.1210/jc.86.10.4753
Sakata, 2002, Ghrelin-producing cells exist as two types of cells, closed- and opened-type cells, in the rat gastrointestinal tract, Peptides, 23, 531, 10.1016/S0196-9781(01)00633-7
Jeon, 2004, Changes in plasma ghrelin concentration immediately after gastrectomy in patients with early gastric cancer, J Clin Endocrinol Metab, 89, 5392, 10.1210/jc.2004-0872
Dornonville de la Cour, 2005, Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice, Gut, 54, 907, 10.1136/gut.2004.058578
Krsek, 2002, Plasma ghrelin levels in patients with short bowel syndrome, Endocr Res, 28, 27, 10.1081/ERC-120004535
Prado, 2004, Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development, Proc Natl Acad Sci U S A, 101, 2924, 10.1073/pnas.0308604100
Wierup, 2004, Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells, J Histochem Cytochem, 52, 301, 10.1177/002215540405200301
Wierup, 2005, Ultrastructure of islet ghrelin cells in the human fetus, Cell Tissue Res, 319, 423, 10.1007/s00441-004-1044-x
Heller, 2005, Genetic determinants of pancreatic epsilon-cell development, Dev Biol, 286, 217, 10.1016/j.ydbio.2005.06.041
Chanoine, 2004, Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting, Endocrinology, 145, 3813, 10.1210/en.2004-0053
Dezaki, 2004, Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents, Diabetes, 53, 3142, 10.2337/diabetes.53.12.3142
Faulconbridge, 2003, Hyperphagic effects of brainstem ghrelin administration, Diabetes, 52, 2260, 10.2337/diabetes.52.9.2260
Keen-Rhinehart, 2004, Peripheral ghrelin injections stimulate food intake, foraging and food hoarding in Siberian hamsters, Am J Physiol Regul Integr Comp Physiol, 288, R716, 10.1152/ajpregu.00705.2004
Davidson, 2005, The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation, Peptides, 26, 1602, 10.1016/j.peptides.2005.02.014
Masuda, 2000, Ghrelin stimulates gastric acid secretion and motility in rats, Biochem Biophys Res Commun, 276, 905, 10.1006/bbrc.2000.3568
Trudel, 2002, Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat, Am J Physiol Gastrointest Liver Physiol, 282, G948, 10.1152/ajpgi.00339.2001
Dornonville de la Cour, 2004, Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells, Regul Pept, 120, 23, 10.1016/j.regpep.2004.02.008
Trudel, 2003, Two new peptides to improve post-operative gastric ileus in dog, Peptides, 24, 531, 10.1016/S0196-9781(03)00113-X
De Winter, 2004, Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice, Neurogastroenterol Motil, 16, 439, 10.1111/j.1365-2982.2004.00564.x
Asakawa, 2003, Antagonism of ghrelin receptor reduces food intake and body weight gain in mice, Gut, 52, 947, 10.1136/gut.52.7.947
Date, 2001, Ghrelin acts in the central nervous system to stimulate gastric acid secretion, Biochem Biophys Res Commun, 280, 904, 10.1006/bbrc.2000.4212
Brzozowski, 2004, Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage, Regul Pept, 120, 39, 10.1016/j.regpep.2004.02.010
Sato, 2003, Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats, Jpn J Physiol, 53, 443, 10.2170/jjphysiol.53.443
Witek, 2005, Effect of ghrelin on activities of some lysosomal hydrolases in rabbits, Neuro Endocrinol Lett, 26, 397
Cummings, 2003, Roles for ghrelin in the regulation of appetite and body weight, Arch Surg, 138, 389, 10.1001/archsurg.138.4.389
Lu, 2002, Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake, Endocrinology, 143, 3905, 10.1210/en.2002-220150
Crowley, 2005, Differential effects of methamphetamine on expression of neuropeptide Y mRNA in hypothalamus and on serum leptin and ghrelin concentrations in ad libitum-fed and schedule-fed rats, Neuroscience, 132, 167, 10.1016/j.neuroscience.2004.11.037
Shiiya, 2002, Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion, J Clin Endocrinol Metab, 87, 240, 10.1210/jc.87.1.240
Williams, 2003, Meal-related ghrelin suppression requires postgastric feedback, Endocrinology, 144, 2765, 10.1210/en.2003-0381
Tschop, 2001, Post-prandial decrease of circulating human ghrelin levels, J Endocrinol Invest, 24, RC19, 10.1007/BF03351037
Cummings, 2001, A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans, Diabetes, 50, 1714, 10.2337/diabetes.50.8.1714
Cummings, 2002, Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery, N Engl J Med, 346, 1623, 10.1056/NEJMoa012908
Weigle, 2003, Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet, J Clin Endocrinol Metab, 88, 1577, 10.1210/jc.2002-021262
Sugino, 2002, A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep, Biochem Biophys Res Commun, 298, 785, 10.1016/S0006-291X(02)02572-X
Miura, 2004, Changes in plasma ghrelin and growth hormone concentrations in mature Holstein cows and three-month-old calves, J Anim Sci, 82, 1329, 10.2527/2004.8251329x
Yokoyama, 2005, Influencing the between-feeding and endocrine responses of plasma ghrelin in healthy dogs, Eur J Endocrinol, 152, 155, 10.1530/eje.1.01818
Drazen, 2006, Effects of a fixed meal pattern on ghrelin secretion: evidence for a learned response independent of nutrient status, Endocrinology, 147, 23, 10.1210/en.2005-0973
Cummings, 2004, Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues, Am J Physiol Endocrinol Metab, 287, E297, 10.1152/ajpendo.00582.2003
Blom, 2005, Ghrelin response to carbohydrate-enriched breakfast is related to insulin, Am J Clin Nutr, 81, 367, 10.1093/ajcn.81.2.367
Murakami, 2002, Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats, J Endocrinol, 174, 283, 10.1677/joe.0.1740283
Sanchez, 2004, Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats, Pflugers Arch, 448, 500, 10.1007/s00424-004-1283-4
Bodosi, 2004, Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation, Am J Physiol Regul Integr Comp Physiol, 287, R1071, 10.1152/ajpregu.00294.2004
Tolle, 2002, Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats, Endocrinology, 143, 1353, 10.1210/en.143.4.1353
Callahan, 2004, Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans, J Clin Endocrinol Metab, 89, 1319, 10.1210/jc.2003-031267
Erdmann, 2004, Postprandial response of plasma ghrelin levels to various test meals in relation to food intake, plasma insulin, and glucose, J Clin Endocrinol Metab, 89, 3048, 10.1210/jc.2003-031610
Korbonits, 2004, Characteristics of the ghrelin receptor in relation to eating behaviour
Overduin, 2004, Role of the duodenum and macronutrient type in ghrelin regulation, Endocrinology, 10.1210/en.2004-0609
Foster-Schubert, 2004, Lipids suppress human plasma ghrelin levels less effectively than do carbohydrates or proteins
Monteleone, 2003, Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women, J Clin Endocrinol Metab, 88, 5510, 10.1210/jc.2003-030797
Lejeune, 2006, Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber, Am J Clin Nutr, 83, 89, 10.1093/ajcn/83.1.89
Gelling, 2004, Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding, Endocrinology, 145, 4575, 10.1210/en.2004-0605
Williams, 2003, Vagotomy dissociates short- and long-term controls of circulating ghrelin, Endocrinology, 144, 5184, 10.1210/en.2003-1059
Overduin, 2004, Peripheral nervous contribution to nutrient-related ghrelin regulation in rats
Arosio, 2004, Effects of modified sham feeding on ghrelin levels in healthy human subjects, J Clin Endocrinol Metab, 89, 5101, 10.1210/jc.2003-032222
Heath, 2004, Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans, J Endocrinol, 180, 273, 10.1677/joe.0.1800273
Nedvidkova, 2003, Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa, J Clin Endocrinol Metab, 88, 1678, 10.1210/jc.2002-021669
Erdmann, 2003, Differential effect of protein and fat on plasma ghrelin levels in man, Regul Pept, 116, 101, 10.1016/S0167-0115(03)00195-2
Teff, 2004, Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women, J Clin Endocrinol Metab, 89, 2963, 10.1210/jc.2003-031855
English, 2002, Food fails to suppress ghrelin levels in obese humans, J Clin Endocrinol Metab, 87, 2984, 10.1210/jc.87.6.2984
Morpurgo, 2003, Ghrelin secretion in severely obese subjects before and after a 3-week integrated body mass reduction program, J Endocrinol Invest, 26, 723, 10.1007/BF03347353
Korner, 2005, Effects of roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, PYY and insulin, J Clin Endocrinol Metab, 90, 359, 10.1210/jc.2004-1076
Tentolouris, 2004, Differential effects of high-fat and high-carbohydrate content isoenergetic meals on plasma active ghrelin concentrations in lean and obese women, Horm Metab Res, 36, 559, 10.1055/s-2004-825761
Perreault, 2004, Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss, Int J Obes Relat Metab Disord, 28, 879, 10.1038/sj.ijo.0802640
Morinigo, 2004, Short-term effects of gastric bypass surgery on circulating ghrelin levels, Obes Res, 12, 1108, 10.1038/oby.2004.139
Tschop, 2001, Circulating ghrelin levels are decreased in human obesity, Diabetes, 50, 707, 10.2337/diabetes.50.4.707
Cummings, 2002, Elevated plasma ghrelin levels in Prader–Willi syndrome, Nat Med, 8, 643, 10.1038/nm0702-643
Tolle, 2003, Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women, J Clin Endocrinol Metab, 88, 109, 10.1210/jc.2002-020645
Otto, 2001, Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa, Eur J Endocrinol, 145, 669, 10.1530/EJE-1450669
Haqq, 2003, Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader–Willi syndrome, J Clin Endocrinol Metab, 88, 174, 10.1210/jc.2002-021052
Wisse, 2001, Reversal of cancer anorexia by blockade of central melanocortin receptors in rats, Endocrinology, 142, 3292, 10.1210/en.142.8.3292
Hansen, 2002, Weight loss increases circulating levels of ghrelin in human obesity, Clin Endocrinol (Oxf), 56, 203, 10.1046/j.0300-0664.2001.01456.x
Leidy, 2004, Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women, J Clin Endocrinol Metab, 89, 2659, 10.1210/jc.2003-031471
Zahorska-Markiewicz, 2004, Effect of weight reduction on serum ghrelin and TNFalpha concentrations in obese women, Eur J Intern Med, 15, 172, 10.1016/j.ejim.2004.02.002
Shimizu, 2003, Increased plasma ghrelin level in lung cancer cachexia, Clin Cancer Res, 9, 774
Hanada, 2003, Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells, Biochem Biophys Res Commun, 301, 275, 10.1016/S0006-291X(02)03028-0
Hanada, 2004, Upregulation of ghrelin expression in cachectic nude mice bearing human melanoma cells, Metabolism, 53, 84, 10.1016/j.metabol.2003.06.004
Garcia, 2005, Active ghrelin levels and active-to-total ghrelin ratio in cancer-induced cachexia, J Clin Endocrinol Metab, 90, 2920, 10.1210/jc.2004-1788
Popovic, 2004, Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's disease, Eur J Endocrinol, 151, 451, 10.1530/eje.0.1510451
Rigamonti, 2002, Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients, J Endocrinol, 175, R1, 10.1677/joe.0.175R001
Nakai, 2003, Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa, Eur J Endocrinol, 149, R1, 10.1530/eje.0.149R001
Tanaka, 2004, Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa, Regul Pept, 122, 163, 10.1016/j.regpep.2004.06.015
Misra, 2004, Growth hormone and ghrelin responses to an oral glucose load in adolescent girls with anorexia nervosa and controls, J Clin Endocrinol Metab, 89, 1605, 10.1210/jc.2003-031861
Stock, 2005, Ghrelin, PYY, GIP and hunger responses to a mixed meal in anorexic, obese and control female adolescents, J Clin Endocrinol Metab, 90, 2161, 10.1210/jc.2004-1251
Kojima, 2005, Altered ghrelin and peptide YY responses to meals in bulimia nervosa, Clin Endocrinol (Oxf), 62, 74, 10.1111/j.1365-2265.2004.02176.x
Misra, 2005, Secretory dynamics of ghrelin in adolescent girls with anorexia nervosa and healthy adolescents, Am J Physiol Endocrinol Metab, 289, E347, 10.1152/ajpendo.00615.2004
Otto, 2005, Postprandial ghrelin release in anorectic patients before and after weight gain, Psychoneuroendocrinology, 30, 577, 10.1016/j.psyneuen.2005.01.009
Nagaya, 2001, Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors, Circulation, 104, 2034, 10.1161/hc4201.097836
Itoh, 2004, Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 170, 879, 10.1164/rccm.200310-1404OC
Marchesini, 2004, Plasma ghrelin concentrations, food intake, and anorexia in liver failure, J Clin Endocrinol Metab, 89, 2136, 10.1210/jc.2003-031771
Yoshimoto, 2002, Plasma ghrelin and desacyl ghrelin concentrations in renal failure, J Am Soc Nephrol, 13, 2748, 10.1097/01.ASN.0000032420.12455.74
Perez-Fontan, 2004, Plasma ghrelin levels in patients undergoing haemodialysis and peritoneal dialysis, Nephrol Dial Transplant, 19, 2095, 10.1093/ndt/gfh313
Chang, 2005, The relationship of plasma ghrelin level to energy regulation, feeding and left ventricular function in non-diabetic haemodialysis patients, Nephrol Dial Transplant, 20, 2172, 10.1093/ndt/gfi011
Cummings, 2004, Circulating ghrelin levels in pathophysiologcial conditions, 207
Kim, 2003, Changes in ghrelin and ghrelin receptor expression according to feeding status, Neuroreport, 14, 1317, 10.1097/00001756-200307180-00006
Nogueiras, 2004, Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin, Diabetes, 53, 2552, 10.2337/diabetes.53.10.2552
Tups, 2004, Circulating ghrelin levels and central ghrelin receptor expression are elevated in response to food deprivation in a seasonal mammal (Phodopus sungorus), J Neuroendocrinol, 16, 922, 10.1111/j.1365-2826.2004.01251.x
Kurose, 2005, Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means, J Neuroendocrinol, 17, 331, 10.1111/j.1365-2826.2005.01318.x
Tung, 2005, Central responsiveness to a ghrelin mimetic (GHRP-6) is rapidly altered by acute changes in nutritional status in rats, J Neuroendocrinol, 17, 387, 10.1111/j.1365-2826.2005.01316.x
Williams DL, Grill HJ, Cummings DE, Kaplan JM. Overfeeding-induced weight gain suppresses plasma ghrelin levels in rats. J Endocrinol Invest in press.
Otukonyong, 2005, High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats, Obes Res, 13, 991, 10.1038/oby.2005.116
Robertson, 2004, Plasma ghrelin response following a period of acute overfeeding in normal weight men, Int J Obes Relat Metab Disord, 28, 727, 10.1038/sj.ijo.0802637
Moesgaard, 2004, Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach, Regul Pept, 120, 261, 10.1016/j.regpep.2004.03.018
Beck, 2002, Ghrelin, macronutrient intake and dietary preferences in Long–Evans rats, Biochem Biophys Res Commun, 292, 1031, 10.1006/bbrc.2002.6737
Otto, 2004, Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans, Eur J Endocrinol, 151, 113, 10.1530/eje.0.1510113
Capristo, 2005, Reduced plasma ghrelin concentration in celiac disease after gluten-free diet treatment, Scand J Gastroenterol, 40, 430, 10.1080/00365520510012028
Soriano-Guillen, 2004, Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation, J Pediatr, 144, 36, 10.1016/j.jpeds.2003.10.036
Foster, 2002, Changes in human plasma ghrelin and leptin levels correlate negatively with each other during aerobic exercise training
Dall, 2002, Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients, Eur J Endocrinol, 147, 65, 10.1530/eje.0.1470065
Jorgensen, 2003, Exercise, hormones, and body temperature. regulation and action of GH during exercise, J Endocrinol Invest, 26, 838, 10.1007/BF03345233
Kraemer, 2004, Rigorous running increases growth hormone and insulin-like growth factor-I without altering ghrelin, Exp Biol Med (Maywood), 229, 240, 10.1177/153537020422900304
Schmidt, 2004, Acute exercise has no effect on ghrelin plasma concentrations, Horm Metab Res, 36, 174, 10.1055/s-2004-814342
De Souza, 2004, Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones, J Clin Endocrinol Metab, 89, 3536, 10.1210/jc.2003-032007
Zoladz, 2005, Effect of moderate incremental exercise, performed in fed and fasted state on cardio-respiratory variables and leptin and ghrelin concentrations in young healthy men, J Physiol Pharmacol, 56, 63
Bush, 2003, Effects of low-calorie or low-fat diet-induced weight loss on plasma ghrelin levels
Qader, 2005, Long-term infusion of nutrients (total parenteral nutrition) suppresses circulating ghrelin in food-deprived rats, Regul Pept, 131, 82, 10.1016/j.regpep.2005.07.002
McLaughlin, 2004, Plasma ghrelin concentrations are decreased in insulin-resistant obese adults relative to equally obese insulin-sensitive controls, J Clin Endocrinol Metab, 89, 1630, 10.1210/jc.2003-031572
Purnell, 2003, Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans, J Clin Endocrinol Metab, 88, 5747, 10.1210/jc.2003-030513
Cummings, 2003, Ghrelin-leptin tango in body-weight regulation, Gastroenterology, 124, 1532, 10.1016/S0016-5085(03)00350-0
Chanoine, 2002, Immunoreactive ghrelin in human cord blood: relation to anthropometry, leptin, and growth hormone, J Pediatr Gastroenterol Nutr, 35, 282, 10.1097/00005176-200209000-00009
Soriano-Guillen, 2004, Ghrelin levels from fetal life through early adulthood: relationship with endocrine and metabolic and anthropometric measures, J Pediatr, 144, 30, 10.1016/j.jpeds.2003.08.050
Onal, 2004, Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers, J Endocrinol, 180, 267, 10.1677/joe.0.1800267
Cortelazzi, 2003, Circulating levels of ghrelin in human fetuses, Eur J Endocrinol, 149, 111, 10.1530/eje.0.1490111
Farquhar, 2003, Elevated umbilical cord ghrelin concentrations in small for gestational age neonates, J Clin Endocrinol Metab, 88, 4324, 10.1210/jc.2003-030265
Kitamura, 2003, Ghrelin concentration in cord and neonatal blood: relation to fetal growth and energy balance, J Clin Endocrinol Metab, 88, 5473, 10.1210/jc.2002-021350
Yokota, 2005, Concentration of the n-octanoylated active form of ghrelin in fetal and neonatal circulation, Endocr J, 52, 271, 10.1507/endocrj.52.271
Ng, 2005, Ghrelin in preterm and term newborns: relation to anthropometry, leptin and insulin, Clin Endocrinol (Oxf), 63, 217, 10.1111/j.1365-2265.2005.02328.x
Desai, 2004, Programmed obesity in intrauterine growth restricted newborns: modulation by newborn nutrition, Am J Physiol Regul Integr Comp Physiol, 10.1152/ajpregu.00340.2004
Iniguez, 2002, Fasting and post-glucose ghrelin levels in SGA infants: relationships with size and weight gain at one year of age, J Clin Endocrinol Metab, 87, 5830, 10.1210/jc.2002-021206
Soto, 2005, Fetal growth restriction and insulin resistance. New findings and review of the literature, Rev Med Chil, 133, 97
Gohlke, 2005, Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth, J Clin Endocrinol Metab, 90, 2270, 10.1210/jc.2004-1192
James, 2004, Low cord ghrelin levels in term infants are associated with slow weight gain over the first 3 months of life, J Clin Endocrinol Metab, 89, 3847, 10.1210/jc.2003-032167
Astrup, 2002, Low-fat diets and energy balance: how does the evidence stand in 2002, Proc Nutr Soc, 61, 299, 10.1079/PNS2002149
Reinehr, 2005, Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents, Int J Obes (Lond), 29, 362, 10.1038/sj.ijo.0802913
De Luca, 2004, Progress in implantable gastric stimulation: summary of results of the European multi-center study, Obes Surg, 14, S33, 10.1381/0960892041978935
Mun, 2001, Current status of medical and surgical therapy for obesity, Gastroenterology, 120, 669, 10.1053/gast.2001.22430
Cummings, 2003, Ghrelin and gastric bypass: is there a hormonal contribution to surgical weight loss?, J Clin Endocrinol Metab, 88, 2999, 10.1210/jc.2003-030705
Geloneze, 2003, Ghrelin: a gut–brain hormone: effect of gastric bypass surgery, Obes Surg, 13, 17, 10.1381/096089203321136539
Fruhbeck, 2004, Fundus functionality and ghrelin concentrations after bariatric surgery, N Engl J Med, 350, 308, 10.1056/NEJM200401153500323
Faraj, 2003, Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects, J Clin Endocrinol Metab, 88, 1594, 10.1210/jc.2002-021309
Leonetti, 2003, Different plasma ghrelin levels after laparoscopic gastric bypass and adjustable gastric banding in morbid obese subjects, J Clin Endocrinol Metab, 88, 4227, 10.1210/jc.2003-030133
Tritos, 2003, Serum ghrelin levels in response to glucose load in obese subjects post-gastric bypass surgery, Obes Res, 11, 919, 10.1038/oby.2003.126
Fruhbeck, 2004, The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus, Obes Surg, 14, 606, 10.1381/096089204323093363
Stoeckli, 2004, Changes of body weight and plasma ghrelin levels after gastric banding and gastric bypass, Obes Res, 12, 346, 10.1038/oby.2004.43
Lin, 2004, The effects of gastric surgery on systemic ghrelin levels in the morbidly obese, Arch Surg, 139, 780, 10.1001/archsurg.139.7.780
Fruhbeck, 2004, Fasting plasma ghrelin concentrations 6 months after gastric bypass are not determined by weight loss or changes in insulinemia, Obes Surg, 14, 1208, 10.1381/0960892042386904
Stylopoulos, 2005, Changes in serum ghrelin predict weight loss after Roux-en-Y gastric bypass in rats, Surg Endosc, 19, 942, 10.1007/s00464-004-8825-x
Holdstock, 2003, Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans, J Clin Endocrinol Metab, 88, 3177, 10.1210/jc.2002-021734
Vendrell, 2004, Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity, Obes Res, 12, 962, 10.1038/oby.2004.118
Cummings, 2004, Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution, J Clin Endocrinol Metab, 89, 2608, 10.1210/jc.2004-0433
Willesen, 1999, Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat, Neuroendocrinology, 70, 306, 10.1159/000054491
Mondal, 2005, Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus, Regul Pept, 126, 55, 10.1016/j.regpep.2004.08.038
Cowley, 2003, The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis, Neuron, 37, 649, 10.1016/S0896-6273(03)00063-1
van den Top, 2004, Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus, Nat Neurosci, 7, 493, 10.1038/nn1226
Dickson, 1997, Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagoguem, GH-releasing peptide-6, Endocrinology, 138, 771, 10.1210/en.138.2.771
Kamegai, 2000, Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression, Endocrinology, 141, 4797, 10.1210/en.141.12.4797
Kamegai, 2001, Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats, Diabetes, 50, 2438, 10.2337/diabetes.50.11.2438
Shintani, 2001, Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway, Diabetes, 50, 227, 10.2337/diabetes.50.2.227
Wang, 2002, Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus, Neurosci Lett, 325, 47, 10.1016/S0304-3940(02)00241-0
Lawrence, 2002, Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers, Endocrinology, 143, 155, 10.1210/en.143.1.155
Seoane, 2003, Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus, Endocrinology, 144, 544, 10.1210/en.2002-220795
Hewson, 2000, Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats, J Neuroendocrinol, 12, 1047, 10.1046/j.1365-2826.2000.00584.x
Date, 2002, The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats, Gastroenterology, 123, 1120, 10.1053/gast.2002.35954
Melis, 2002, Ghrelin injected into the paraventricular nucleus of the hypothalamus of male rats induces feeding but not penile erection, Neurosci Lett, 329, 339, 10.1016/S0304-3940(02)00673-0
Bagnasco, 2003, Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting, Regul Pept, 111, 161, 10.1016/S0167-0115(02)00283-5
Bewick, 2005, Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype, FASEB J, 19, 1680, 10.1096/fj.04-3434fje
Naleid, 2005, Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens, Peptides, 26, 2274, 10.1016/j.peptides.2005.04.025
Carlini, 2004, Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin, Biochem Biophys Res Commun, 313, 635, 10.1016/j.bbrc.2003.11.150
Diano, 2006, Ghrelin controls hippocampal spine synapse density and memory performance, Nat Neurosci, 9, 381, 10.1038/nn1656
Pan, 2006, Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin, Peptides, 27, 911, 10.1016/j.peptides.2005.12.014
Sato, 2005, Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration, Endocrinology, 146, 2510, 10.1210/en.2005-0174
Johnstone, 2005, Hypothalamic expression of NPY mRNA, vasopressin mRNA and CRF mRNA in response to food restriction and central administration of the orexigenic peptide GHRP-6, Stress, 8, 59, 10.1080/10253890500095283
West, 1984, Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats, Am J Physiol, 246, R776
Shimbara, 2004, Central administration of ghrelin preferentially enhances fat ingestion, Neurosci Lett, 369, 75, 10.1016/j.neulet.2004.07.060
Choi, 2003, The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis, Endocrinology, 144, 754, 10.1210/en.2002-220783
Thompson, 2004, Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor, Endocrinology, 145, 234, 10.1210/en.2003-0899
Kim, 2004, The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes, Mol Endocrinol, 18, 2291, 10.1210/me.2003-0459
Tsubone, 2005, Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice, Regul Pept, 130, 97, 10.1016/j.regpep.2005.04.004
Yasuda, 2003, Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats, Neurosci Lett, 349, 75, 10.1016/S0304-3940(03)00789-4
Barazzoni, 2004, Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution favoring triglyceride deposition in liver but not skeletal muscle, Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00115.2004
Muccioli, 2004, Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor, Eur J Pharmacol, 498, 27, 10.1016/j.ejphar.2004.07.066
Currie, 2005, Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei, Am J Physiol Regul Integr Comp Physiol, 289, R353, 10.1152/ajpregu.00756.2004
Matsumura, 2002, Central ghrelin modulates sympathetic activity in conscious rabbits, Hypertension, 40, 694, 10.1161/01.HYP.0000035395.51441.10
Dixit, 2004, Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells, J Clin Invest, 114, 57, 10.1172/JCI200421134
Li, 2004, Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells, Circulation, 109, 2221, 10.1161/01.CIR.0000127956.43874.F2
Dembinski, 2003, Ghrelin attenuates the development of acute pancreatitis in rat, J Physiol Pharmacol, 54, 561
Tang-Christensen, 2004, Central administration of ghrelin and agouti-related protein (83–132) increases food intake and decreases spontaneous locomotor activity in rats, Endocrinology, 145, 4645, 10.1210/en.2004-0529
DelParigi, 2002, High circulating ghrelin: a potential cause for hyperphagia and obesity in Prader–Willi syndrome, J Clin Endocrinol Metab, 87, 5461, 10.1210/jc.2002-020871
Hoybye, 2004, Endocrine and metabolic aspects of adult Prader–Willi syndrome with special emphasis on the effect of growth hormone treatment, Growth Horm IGF Res, 14, 1, 10.1016/j.ghir.2003.09.003
Goldstone, 2004, Elevated fasting plasma ghrelin in Prader–Willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance, J Clin Endocrinol Metab, 89, 1718, 10.1210/jc.2003-031118
Tauber, 2004, Hyperghrelinemia is a common feature of Prader–Willi syndrome and pituitary stalk interruption: a pathophysiological hypothesis, Horm Res, 62, 49, 10.1159/000078862
Paik, 2004, Correlation between fasting plasma ghrelin levels and age, body mass index (BMI), BMI percentiles, and 24-hour plasma ghrelin profiles in Prader–Willi syndrome, J Clin Endocrinol Metab, 89, 3885, 10.1210/jc.2003-032137
Goldstone, 2005, Fasting and postprandial hyperghrelinemia in Prader–Willi syndrome is partially explained by hypoinsulinemia, and is not due to peptide YY3-36 deficiency or seen in hypothalamic obesity due to craniopharyngioma, J Clin Endocrinol Metab, 90, 2681, 10.1210/jc.2003-032209
Choe, 2005, Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader–Willi syndrome, J Clin Endocrinol Metab, 90, 5441, 10.1210/jc.2004-1935
Butler, 2004, Plasma peptide YY and ghrelin levels in infants and children with Prader–Willi syndrome, J Pediatr Endocrinol Metab, 17, 1177, 10.1515/JPEM.2004.17.9.1177
Choe, 2005, Hyperghrelinemia does not accelerate gastric emptying in Prader–Willi syndrome patients, J Clin Endocrinol Metab, 90, 3367, 10.1210/jc.2004-1651
Erdie-Lalena CR, Holm VA, Kelly PC, Frayo RS, Cummings DE. Ghrelin levels in very young children with Prader–Willi syndrome. J Pediatr in press.
Kanumakala, 2005, Fasting ghrelin levels are not elevated in children with hypothalamic obesity, J Clin Endocrinol Metab, 90, 2691, 10.1210/jc.2004-2175
Daousi, 2005, Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?, J Clin Endocrinol Metab, 90, 5025, 10.1210/jc.2004-1874
Haqq, 2003, Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader–Willi syndrome, J Clin Endocrinol Metab, 88, 3573, 10.1210/jc.2003-030205
Tan, 2004, Somatostatin infusion lowers plasma ghrelin without reducing appetite in adults with Prader–Willi syndrome, J Clin Endocrinol Metab, 89, 4162, 10.1210/jc.2004-0835
Miyasaka, 2002, Inhibitory effects of octreotide on luminal cholecystokinin-releasing factor, plasma cholecystokinin, and pancreatic secretion in conscious rats, Pancreas, 24, 269, 10.1097/00006676-200204000-00010
Ranganath, 1999, Inhibition of insulin, GIP, and GLP-1 secretion by octreotide has no effect on post-heparin lipoprotein lipase activity, Horm Metab Res, 31, 262, 10.1055/s-2007-978729
Tsolakis, 2004, Malignant gastric ghrelinoma with hyperghrelinemia, J Clin Endocrinol Metab, 89, 3739, 10.1210/jc.2003-032118
Shuto, 2002, Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity, J Clin Invest, 109, 1429, 10.1172/JCI0213300
Wortley, 2004, Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference, Proc Natl Acad Sci U S A, 101, 8227, 10.1073/pnas.0402763101
Sun, 2003, Deletion of ghrelin impairs neither growth nor appetite, Mol Cell Biol, 23, 7973, 10.1128/MCB.23.22.7973-7981.2003
Luquet, 2005, NPY/Agrp neurons are essential for feeding in adult mice but can be ablated in neonates, Science, 310, 585, 10.1126/science.1115524
Zhang, 2005, Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake, Science, 310, 996, 10.1126/science.1117255
Wortley, 2005, Absence of ghrelin protects against early-onset obesity, J Clin Invest, 115, 3573, 10.1172/JCI26003
Zigman, 2005, Mice lacking ghrelin receptors resist the development of diet-induced obesity, J Clin Invest, 115, 3564, 10.1172/JCI26002
Helmling, 2004, Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer, Proc Natl Acad Sci U S A, 101, 13174, 10.1073/pnas.0404175101
Shearman, 2006, Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice, Endocrinology, 147, 1517, 10.1210/en.2005-0993
Kobelt, 2005, Anti-ghrelin SPIEGELMER NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats, Gut, 55, 788, 10.1136/gut.2004.061010
Cummings, 2004, Helicobacter pylori and ghrelin: interrelated players in body-weight regulation?, Am J Med, 117, 436, 10.1016/j.amjmed.2004.07.034