Ghrelin Regulates Hippocampal Neurogenesis in Adult Mice

Endocrine Journal - Tập 56 Số 3 - Trang 525-531 - 2009
Minho Moon1, Sehee Kim1, Lakkyong Hwang1, Seungjoon Park1
1Department of Pharmacology and Medical Research Center for Bioreaction to ROS and Biomedical Science Institute, Kyunghee University School of Medicine

Tóm tắt

Từ khóa


Tài liệu tham khảo

1. Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. <I>Annu Rev Neurosci </I>28:223-250.

10.1016/j.cell.2008.01.033

10.1016/S0306-4522(03)00199-4

10.1038/45230

10.1210/en.141.11.4255

6. Soares JB, Leite-Moreira AF (2008) Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. <I>Peptides </I>29:1255-1270.

10.1210/en.2005-0708

10.1016/j.bbrc.2006.09.088

9. Zhang W, Hu Y, Lin TR, Fan Y, Mulholland MW (2005) Stimulation of neurogenesis in rat nucleus of the solitary tract by ghrelin. <I>Peptides </I>26:2280-2288.

10. Zhang W, Lin TR, Hu Y, Fan Y, Zhao L, Stuenkel EL, Mulholland MW (2004) Ghrelin stimulates neurogenesis in the dorsal motor nucleus of the vagus. <I>J Physiol </I>559:729-737.

11. Johansson I, Destefanis S, Aberg ND, Aberg MA, Blomgren K, Zhu C, Ghe C, Granata R, Ghigo E, Muccioli G, Eriksson PS, Isgaard J (2008) Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells. <I>Endocrinology </I>149:2191-2199.

12. Moon M, Huh Y, Park C (2006) L-nitroimidazole ornithine limits exercise-induced increases in cell proliferation in the hippocampus of adult mice. <I>Neuroreport </I>17:1121-1125.

13. Mandyam CD, Harburg GC, Eisch AJ (2007) Determination of key aspects of precursor cell proliferation, cell cycle length and kinetics in the adult mouse subgranular zone. <I>Neuroscience </I>146:108-122.

10.1126/science.7123245

15. Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park S (2007) Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. <I>Endocrinology </I>148:148-159.

16. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N, Bogdahn U, Winkler J, Kuhn HG, Aigner L (2005) Doublecortin expression levels in adult brain reflect neurogenesis. <I>Eur J Neurosci </I>21:1-14.

17. Xu G, Li Y, An W, Zhang W (2008) Ghrelin and cell differentiation. <I>Acta Biochim Biophys Sin (Shanghai) </I>40:841-847.

18. Liu Y, Wang PS, Xie D, Liu K, Chen L (2006) Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. <I>Chin J Physiol </I>49:244-250.

19. Chung H, Seo S, Moon M, Park S (2008) Phosphatidylinositol- 3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. <I>J Endocrinol </I>198:511-521.

20. Squire LR, Zola SM (1996) Ischemic brain damage and memory impairment: a commentary. <I>Hippocampus </I>6:546-552.

21. Grote HE, Hannan AJ (2007) Regulators of adult neurogenesis in the healthy and diseased brain. <I>Clin Exp Pharmacol Physiol </I>34:533-545.

22. Butler CR, Zeman AZ (2008) Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. <I>Brain </I>131:2243-2263.

23. Obay BD, Tasdemir E, Tumer C, Bilgin HM, Sermet A (2007) Antiepileptic effects of ghrelin on pentylenetetrazole- induced seizures in rats. <I>Peptides </I>28:1214-1219.

10.1038/nn1656