Gene Ontology: tool for the unification of biology

Goffeau, A. et al. Life with 6000 genes. Science 274, 546 (1996).

Worm Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. The C. elegans Sequencing Consortium. Science 282, 2012–2018 (1998).

Adams, M.D. et al. The genome sequence of Drosophila melanogaster. Science 287, 2185–2195 (2000).

Meinke, D.W. et al. Arabidopsis thaliana: a model plant for genome analysis. Science 282, 662–682 (1998).

Chervitz, S.A. et al. Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Res. 27, 74–78 (1999).

Rubin, G.M. et al. Comparative genomics of the eukaryotes. Science 287, 2204–2215 (2000).

Tang, Z., Kuo, T., Shen, J. & Lin, R.J. Biochemical and genetic conservation of fission yeast Dsk1 and human SR protein-specific kinase 1. Mol. Cell. Biol. 20, 816–824 (2000).

Vajo, Z. et al. Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging. Mamm. Genome 10, 1000–1004 (1999).

Ohi, R. et al. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol. Cell. Biol. 18, 4097–4108 (1998).

Bassett, D.E. Jr et al. Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease. Nature Genet. 15, 339–344 (1997).

Kataoka T. et al. Functional homology of mammalian and yeast RAS genes. Cell 40,19–26 (1985).

Botstein, D. & Fink, G.R. Yeast: an experimental organism for modern biology. Science 240, 1439–1443 (1988).

Tatusov, R.L., Galperin, M.Y., Natale, D.A. & Koonin, E.V. The COG database: a tool for genome-scale analysis of protein functions and evolution. Nucleic Acids Res. 28, 33–36 (2000).

Andrade, M.A. et al. Automated genome sequence analysis and annotation. Bioinformatics 15, 391–412 (1999).

Fleischmann, W., Moller, S., Gateau, A. & Apweiler, R. A novel method for automatic functional annotation of proteins. Bioinformatics 15, 228–233 (1999).

The FlyBase Consortium. The FlyBase database of the Drosophila Genome Projects and community literature. Nucleic Acids Res. 27, 85–88 (1999).

Blake, J.A. et al. The Mouse Genome Database (MGD): expanding genetic and genomic resources for the laboratory mouse. Nucleic Acids Res. 28, 108–111 (2000).

Ringwald, M. et al. GXD: a gene expression database for the laboratory mouse—current status and recent enhancements. Nucleic Acids Res. 28, 115–119 (2000).

Ball, C.A. et al. Integrating functional genomic information into the Saccharomyces Genome Database. Nucleic Acids Res. 28, 77–80 (2000).

Bairoch, A. & Apweiler, R. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 28, 45–48 (2000).

Benson, D.A. et al. GenBank. Nucleic Acids Res. 28, 15–18 (2000).

Baker, W. et al. The EMBL Nucleotide Sequence Database. Nucleic Acids Res. 28, 19–23 (2000).

Tateno, Y. et al. DNA Data Bank of Japan (DDBJ) in collaboration with mass sequencing teams. Nucleic Acids Res. 28, 24–26 (2000).

Barker, W.C. et al. The Protein Information Resource (PIR). Nucleic Acids Res. 28, 41–44 (2000).

Mewes, H.W. et al. MIPS: a database for genomes and protein sequences. Nucleic Acids Res. 28, 37–40 (2000).

Costanzo, M.C. et al. The Yeast Proteome Database (YPD) and Caenorhabditis elegans Proteome Database (WormPD): comprehensive resources for the organization and comparison of model organism protein information. Nucleic Acids Res. 28, 73–76 (2000).

Bateman, A. et al. The Pfam protein families database. Nucleic Acids Res. 28, 263–266 (2000).

Lo Conte, L. et al. SCOP: a structural classification of proteins database. Nucleic Acids Res. 28, 257–259 (2000).

Bairoch, A. The ENZYME database in 2000. Nucleic Acids Res. 28, 304–305 (2000).

Enzyme Nomenclature. Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enyzmes. NC-IUBMB. (Academic, New York, 1992).

Tye, B.K. MCM proteins in DNA replication. Annu. Rev. Biochem. 68, 649–686 (1999).

Eisen, M., Spellman, P.T., Brown, P.O. & Botstein, D. Cluster analysis and display of genome-wide expression patterns. Proc. Natl Acad. Sci. USA 95, 14863–14868 (1998).

Spellman, P.T. et al. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9, 3273–3297 (1998).