Gender-specific effect of urate on white matter integrity in Parkinson's disease

Dickson, 2009, Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria, the Lancet, Neurology, 8, 1150 Braak, 2003, Staging of brain pathology related to sporadic Parkinson's disease, Neurobiol. Aging, 24, 197, 10.1016/S0197-4580(02)00065-9 Niranjan, 2014, The role of inflammatory and oxidative stress mechanisms in the pathogenesis of Parkinson's disease: focus on astrocytes, Mol. Neurobiol., 49, 28, 10.1007/s12035-013-8483-x Davies, 1986, Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid, Biochem. J., 235, 747, 10.1042/bj2350747 Church, 1994, Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation, Brain Res. Bull., 33, 419, 10.1016/0361-9230(94)90285-2 de Lau, 2005, Serum uric acid levels and the risk of Parkinson disease, Ann. Neurol., 58, 797, 10.1002/ana.20663 Annanmaki, 2008, Uric acid associates with cognition in Parkinson's disease, Park. Relat. Disord., 14, 576, 10.1016/j.parkreldis.2007.11.001 Ou, 2017, Serum uric acid levels and freezing of gait in Parkinson's disease, Neurol. Sci. : Off. J. Ital. Neurol. Soc. Ital. Soc. Clin. Neurophysiol., 38, 955, 10.1007/s10072-017-2871-3 Hak, 2008, Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey, Arthritis Res. Ther., 10, R116, 10.1186/ar2519 Anton, 1986, Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17 beta (E2) on the renal handling of urate, Metab. Clin. Exp., 35, 343, 10.1016/0026-0495(86)90152-6 De Santis, 2014, Why diffusion tensor MRI does well only some of the time: variance and covariance of white matter tissue microstructure attributes in the living human brain, Neuroimage, 89, 35, 10.1016/j.neuroimage.2013.12.003 Chu, 2012, Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease, Brain, 135, 2058, 10.1093/brain/aws133 Maas, 2017, Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia, Transl. Psychiatry, 7, e1171, 10.1038/tp.2017.138 Eggers, 2011, Akinetic-rigid and tremor-dominant Parkinson's disease patients show different patterns of FP-CIT single photon emission computed tomography, Mov. Disord. : Off. J. Mov. Disorder Soc., 26, 416, 10.1002/mds.23468 Lee, 2018, Gender-specific effect of uric acid on resting-state functional networks in de novo Parkinson's disease, Park. Relat. Disord., 52, 49, 10.1016/j.parkreldis.2018.03.023 Kim, 2015, Periventricular white matter hyperintensities and the risk of dementia: a CREDOS study, Int. Psychogeriatr., 27, 2069, 10.1017/S1041610215001076 Emre, 2007, Clinical diagnostic criteria for dementia associated with Parkinson's disease, Mov. Disord. : Off. J. Mov. Disorder Soc., 22, 1689, 10.1002/mds.21507 Chung, 2013, Neuroanatomical heterogeneity of essential tremor according to propranolol response, PloS One, 8, 10.1371/journal.pone.0084054 Wei, 2018, Oxidative stress in Parkinson's disease: a systematic review and meta-analysis, Front. Mol. Neurosci., 11, 236, 10.3389/fnmol.2018.00236 Dalfo, 2005, Evidence of oxidative stress in the neocortex in incidental Lewy body disease, J. Neuropathol. Exp. Neurol., 64, 816, 10.1097/01.jnen.0000179050.54522.5a Scherfler, 2011, White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study, Ann. Neurol., 69, 400, 10.1002/ana.22245 French, 2009, Oxidative stress disrupts oligodendrocyte maturation, J. Neurosci. Res., 87, 3076, 10.1002/jnr.22139 Huang, 2018, Serum uric acid level and its association with motor subtypes and non-motor symptoms in early Parkinson's disease: PALS study, Park. Relat. Disord., 55, 50, 10.1016/j.parkreldis.2018.05.010 Vesely, 2016, The contribution of white matter lesions to Parkinson's disease motor and gait symptoms: a critical review of the literature, J. Neural. Transm., 123, 241, 10.1007/s00702-015-1470-9 Bledsoe, 2018, White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease, Neurology, 10.1212/WNL.0000000000006646 Blain, 2006, Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI, Neurology, 67, 2199, 10.1212/01.wnl.0000249307.59950.f8 Alexander, 2007, Diffusion tensor imaging of the brain, Neurotherapeutics : J. Am. Soc. Exp. NeuroTherap., 4, 316, 10.1016/j.nurt.2007.05.011 Gao, 2016, Prospective study of plasma urate and risk of Parkinson disease in men and women, Neurology, 86, 520, 10.1212/WNL.0000000000002351 Schwarzschild, 2008, Serum urate as a predictor of clinical and radiographic progression in Parkinson disease, Arch. Neurol., 65, 716, 10.1001/archneur.2008.65.6.nct70003 Ames, 1981, Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis, Proc. Natl. Acad. Sci. U. S. A., 78, 6858, 10.1073/pnas.78.11.6858