Funktionales Proteom-Display zur Identifikation von Biomarkern

BIOspektrum - Tập 22 Số 3 - Trang 256-259 - 2016
Jonas Zantow1, Stefan Dübel1, Michael Hust1
1Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig, Deutschland

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Tài liệu tham khảo

Kunnath-Velayudhan S, Salamon H, Wang HY et al. (2010) Dynamic antibody responses to the Mycobacterium tuberculosis proteome. Proc Natl Acad Sci USA 107:14703–14708

Türeci O, Sahin U, Pfreundschuh M (1997) Serological analysis of human tumor antigens: molecular definition and implications. Mol Med Today 3:342–349

Schirrmann T, Meyer T, Schütte M et al. (2011) Phage display for the generation of antibodies for proteome research, diagnostics and therapy. Molecules 16:412–426

Zhou M, Meyer T, Koch S et al. (2013) Identification of a new epitope for HIV-neutralizing antibodies in the gp41 membrane proximal external region by an Env-tailored phage display library. Eur J Immunol 43:499–509

Faix PH, Burg MA, Gonzales M et al. (2004) Phage display of cDNA libraries: enrichment of cDNA expression using open reading frame selection. Biotechniques 36:1018–1029

Rondot S, Koch J, Breitling F et al. (2001) A helperphage to improve single chain antibody presentation in phage display. Nat Biotechnol 19:75–78

Hust M, Meysing M, Schirrmann T et al. (2006) Enrichment of open reading frames presented on bacteriophage M13 using hyperphage. Biotechniques 41:335–342

Kügler J, Nieswandt S, Gerlach GF et al. (2008) Identification of immunogenic polypeptides from a Mycoplasma hyopneumoniae genome library by phage display. Appl Microbiol Biotechnol 80:447–458

Naseem S, Meens J, Jores J et al. (2010) Phage display-based identification and potential diagnostic application of novel antigens from Mycoplasma mycoides subsp. mycoides small colony type. Vet Microbiol 142:285–292

Meyer T, Schirrmann T, Frenzel A et al. (2012) Identification of immunogenic proteins and generation of antibodies against Salmonella Typhimurium using phage display. BMC Biotechnol 12:29

Connor DO, Zantow J, Hust M et al. (2016) Identification of novel immunogenic proteins of Neisseria gonorrhoeae by phage display. PLoS One 11:e0148986

Becker M, Felsberger A, Frenzel A et al. (2015) Application of M13 phage display for identifying immunogenic proteins from tick (Ixodes scapularis) saliva. BMC Biotechnol 15:43