Từ sinh học tế bào đến phát triển các phương pháp hóa trị mới chống lại trypanosomatids: những giấc mơ và thực tế.

Kinetoplastid Biology and Disease - Tập 1 Số 1 - Trang 1-21 - 2002
De Souza, Wanderley1
1Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de JaneiroRJ, Brasil

Tóm tắt

Các thành viên của họ Trypanosomatidae bao gồm một số lượng lớn loài gây ra những bệnh quan trọng như bệnh ngủ, bệnh Chagas và bệnh Leishmaniasis. Những sinh vật này cũng rất đáng quan tâm về mặt sinh học vì chúng có khả năng thay đổi hình thái theo môi trường sống thông qua một quá trình chuyển đổi tế bào có thể đảo ngược, và có các cấu trúc cũng như bào quan mà không có trong tế bào động vật có vú. Bài tổng quan này phân tích quá trình chuyển đổi, diễn ra trong vòng đời của Trypanosoma cruzi trong các vật chủ động vật có xương sống và không xương sống. Đặc biệt chú ý đến sự tương tác của ký sinh trùng với tế bào động vật có xương sống. Ngoài ra, kiến thức hiện tại về các cấu trúc và bào quan như nhân, màng tế bào, vi thể ống dưới màng, roi, phức hợp kinetoplast-mitochondrion, peroxisome (glycosome), acidocalcisome và các cấu trúc cũng như bào quan liên quan đến con đường nội thực bào được xem xét từ góc độ sinh học tế bào. Việc sử dụng dữ liệu hiện có để phát triển các loại thuốc chống ký sinh trùng mới cũng được thảo luận.

Từ khóa

#Trypanosomatidae #Trypanosoma cruzi #bệnh ngủ #bệnh Chagas #bệnh Leishmaniasis #sinh học tế bào #thuốc chống ký sinh trùng.

Tài liệu tham khảo

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