Frequencies of pathogenic CFTR variants in Greek cystic fibrosis patients with allergic bronchopulmonary aspergillosis and Aspergillus fumigatus chronic colonization: A retrospective cohort study

www.cftr2.org Bell, 2020, The future of cystic fibrosis care: a global perspective, Lancet Respir Med, 8, 65, 10.1016/S2213-2600(19)30337-6 Bobadilla, 2002, Cystic fibrosis: a worldwide analysis of CFTR mutations—correlation with incidence data and application to screening, Hum Mutat, 19, 575, 10.1002/humu.10041 McCague, 2019, Correlating cystic fibrosis transmembrane conductance regulator function with clinical features to inform precision treatment of cystic fibrosis, Am J Respir Crit Care Med, 199, 1116, 10.1164/rccm.201901-0145OC Rieber, 2014, Current concepts of immune dysregulation in cystic fibrosis, Int J Biochem Cell Biol, 52, 108, 10.1016/j.biocel.2014.01.017 Chaudhary, 2012, Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation, Am J Respir Crit Care Med, 185, 301, 10.1164/rccm.201106-1027OC Ratner, 2012, Immune responses in cystic fibrosis: are they intrinsically defective?, Am J Respir Cell Mol Biol, 46, 715, 10.1165/rcmb.2011-0399RT Allard, 2006, Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator, J Immunol, 177, 5186, 10.4049/jimmunol.177.8.5186 Huang, 2016, The microbiome in cystic fibrosis, Clin Chest Med, 37, 59, 10.1016/j.ccm.2015.10.003 King, 2016, Aspergillus infections in cystic fibrosis, J Infect, 72, S50, 10.1016/j.jinf.2016.04.022 Armstead, 2014, Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis, PLoS One, 9, e98502, 10.1371/journal.pone.0098502 Castellani, 2008, Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice, J Cyst Fibros, 7, 179, 10.1016/j.jcf.2008.03.009 Noni, 2015, Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship, Eur J Clin Microbiol Infect Dis, 34, 2235, 10.1007/s10096-015-2474-y Katelari, 2016, The role of basophil activation test in allergic bronchopulmonary aspergillosis and Aspergillus fumigatus sensitization in cystic fibrosis patients, J Cyst Fibros, 15, 587, 10.1016/j.jcf.2016.02.004 Stevens, 2003, Allergic bronchopulmonary aspergillosis in cystic fibrosis—state of the art: Cystic Fibrosis Foundation Consensus Conference, Clin Infect Dis, 37, S225, 10.1086/376525 Salvatore, 2019, Patients with cystic fibrosis having a residual function mutation: data from the Italian registry, Pediatr Pulmonol, 54, 150, 10.1002/ppul.24215 Klich, 2003, Identification of common Aspergillus specie, Mycologist, 17, 128 Amin, 2010, The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis, Chest, 137, 171, 10.1378/chest.09-1103 Williams, 2016, Pathogenesis of fungal infections in cystic fibrosis, Curr Fungal Infect Rep, 10, 163, 10.1007/s12281-016-0268-z Noni, 2014, Inhaled corticosteroids and Aspergillus fumigatus isolation in cystic fibrosis, Med Mycol, 52, 715, 10.1093/mmy/myu038 Jubin, 2010, Risk factors for Aspergillus colonization and allergic bronchopulmonary aspergillosis in children with cystic fibrosis, Pediatr Pulmonol, 45, 764, 10.1002/ppul.21240 Agarwal, 2009, Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: systematic review and meta-analysis, Int J Tuberc Lung Dis, 13, 936 Maturu, 2015, Prevalence of Aspergillus sensitization and allergic bronchopulmonary aspergillosis in cystic fibrosis: systematic review and meta-analysis, Clin Exp Allergy, 45, 1765, 10.1111/cea.12595 Agarwal, 2011, Allergic bronchopulmonary aspergillosis: lessons learnt from genetics, Indian J Chest Dis Allied Sci, 53, 137, 10.5005/ijcdas-53-3-137 Green, 2010, Mutations that permit residual CFTR function delay acquisition of multiple respiratory pathogens in CF patients, Respir Res, 11, 140, 10.1186/1465-9921-11-140 Fillaux, 2014, Aspergillus sensitization or carriage in cystic fibrosis patients, Pediatr Infect Dis J, 33, 680, 10.1097/INF.0000000000000231 Agarwal, 2012, Link between CFTR mutations and ABPA: a systematic review and meta-analysis, Mycoses, 55, 357, 10.1111/j.1439-0507.2011.02130.x Heltshe, 2015, Pseudomonas aeruginosa in cystic fibrosis patients with G551D-CFTR treated with ivacaftor, Clin Infect Dis, 60, 703, 10.1093/cid/ciu944 Warris, 2019, Immunopathology of Aspergillus infections in children with chronic granulomatous disease and cystic fibrosis, Pediatr Infect Dis J, 38, e96, 10.1097/INF.0000000000002265 Kanavakis, 2003, Cystic fibrosis in Greece: molecular diagnosis, haplotypes, prenatal diagnosis and carrier identification amongst high-risk individuals, Clin Genet, 63, 400, 10.1034/j.1399-0004.2003.00067.x Agarwal, 2013, Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria, Clin Exp Allergy, 43, 850, 10.1111/cea.12141 Hutcheson, 1996, A 12-year longitudinal study of Aspergillus sensitivity in patients with cystic fibrosis, Chest, 110, 363, 10.1378/chest.110.2.363 Warris, 2019, Aspergillus colonization and antifungal immunity in cystic fibrosis patients, Med Mycol, 57, S118, 10.1093/mmy/myy074 Tracy, 2018, The myriad challenges of respiratory fungal infection in cystic fibrosis, Pediatr Pulmonol, 53, S75, 10.1002/ppul.24126 Pashley, 2012, Routine processing procedures for isolating filamentous fungi from respiratory sputum samples may underestimate fungal prevalence, Med Mycol, 50, 433, 10.3109/13693786.2011.615762 Magee, 2021, Managing fungal infections in cystic fibrosis patients: challenges in clinical practice, Infect Drug Resist, 14, 1141, 10.2147/IDR.S267219 Delhaes, 2019, Prevalence, geographic risk factor, and development of a standardized protocol for fungal isolation in cystic fibrosis: results from the international prospective study “MFIP”, J Cyst Fibros, 18, 212, 10.1016/j.jcf.2018.10.001