FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

Cell Metabolism - Tập 6 Số 6 - Trang 472-483 - 2007
Jinghui Zhao1, Jeffrey J. Brault1, Andreas Schild1, Peirang Cao2, Marco Sandri3,4,5, Stefano Schiaffino3,6,5, Stewart H. Lecker2, Alfred L. Goldberg1
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115 USA
2Renal Unit, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
3Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
4Dulbecco Telethon Institute, 35129 Padova, Italy
5Venetian Institute of Molecular Medicine, 35129 Padova, Italy
6Institute of Neuroscience, Consiglio Nazionale delle Ricerche, 35121 Padova, Italy

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Arico, 2001, The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway, J. Biol. Chem., 276, 35243, 10.1074/jbc.C100319200

Barthel, 2005, FoxO proteins in insulin action and metabolism, Trends Endocrinol. Metab., 16, 183, 10.1016/j.tem.2005.03.010

Bechet, 2005, Lysosomal proteolysis in skeletal muscle, Int. J. Biochem. Cell Biol., 37, 2098, 10.1016/j.biocel.2005.02.029

Beehler, 2006, Reduction of skeletal muscle atrophy by a proteasome inhibitor in a rat model of denervation, Exp. Biol. Med. (Maywood), 231, 335, 10.1177/153537020623100315

Bodine, 2001, Identification of ubiquitin ligases required for skeletal muscle atrophy, Science, 294, 1704, 10.1126/science.1065874

Brunet, 1999, Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, Cell, 96, 857, 10.1016/S0092-8674(00)80595-4

Cuervo, 2000, Unique properties of lamp2a compared to other lamp2 isoforms, J. Cell Sci., 113, 4441, 10.1242/jcs.113.24.4441

Dice, 2007, Chaperone-mediated autophagy, Autophagy, 3, 295, 10.4161/auto.4144

Du, 2004, Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions, J. Clin. Invest., 113, 115, 10.1172/JCI18330

Furuno, 1990, Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy, J. Biol. Chem., 265, 8550, 10.1016/S0021-9258(19)38923-9

Glass, 2005, Skeletal muscle hypertrophy and atrophy signaling pathways, Int. J. Biochem. Cell Biol., 37, 1974, 10.1016/j.biocel.2005.04.018

Glickman, 2002, The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction, Physiol. Rev., 82, 373, 10.1152/physrev.00027.2001

Gronostajski, 1984, The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts, J. Cell. Physiol., 121, 189, 10.1002/jcp.1041210124

Iwata, 2005, HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin, J. Biol. Chem., 280, 40282, 10.1074/jbc.M508786200

Juhasz, 2007, Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body, Cell Death Differ., 14, 1181, 10.1038/sj.cdd.4402123

Kandarian, 2006, Intracellular signaling during skeletal muscle atrophy, Muscle Nerve, 33, 155, 10.1002/mus.20442

Kisselev, 2001, Proteasome inhibitors: from research tools to drug candidates, Chem. Biol., 8, 739, 10.1016/S1074-5521(01)00056-4

Klionsky, 2003, A unified nomenclature for yeast autophagy-related genes, Dev. Cell, 5, 539, 10.1016/S1534-5807(03)00296-X

Knecht, 1984, Regulation of lysosomal autophagy in transformed and non-transformed mouse fibroblasts under several growth conditions, Exp. Cell Res., 154, 224, 10.1016/0014-4827(84)90682-7

Kramerova, 2005, Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin-proteasome pathway, Hum. Mol. Genet., 14, 2125, 10.1093/hmg/ddi217

Lecker, 2004, Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression, FASEB J., 18, 39, 10.1096/fj.03-0610com

Lecker, 2006, Protein degradation by the ubiquitin-proteasome pathway in normal and disease states, J. Am. Soc. Nephrol., 17, 1807, 10.1681/ASN.2006010083

Levine, 2004, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Dev. Cell, 6, 463, 10.1016/S1534-5807(04)00099-1

Liang, 1999, Induction of autophagy and inhibition of tumorigenesis by beclin 1, Nature, 402, 672, 10.1038/45257

Mammucari, 2007, FoxO3 controls autophagy in skeletal muscle in vivo, Cell Metab., 6, 10.1016/j.cmet.2007.11.001

Meijer, 2006, Signalling and autophagy regulation in health, aging and disease, Mol. Aspects Med., 27, 411, 10.1016/j.mam.2006.08.002

Melendez, 2003, Autophagy genes are essential for dauer development and life-span extension in C. elegans, Science, 301, 1387, 10.1126/science.1087782

Mizushima, 2001, Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells, J. Cell Biol., 152, 657, 10.1083/jcb.152.4.657

Mizushima, 2004, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Mol. Biol. Cell, 15, 1101, 10.1091/mbc.E03-09-0704

Mortimore, 1983, Quantitative correlation between proteolysis and macro- and microautophagy in mouse hepatocytes during starvation and refeeding, Proc. Natl. Acad. Sci. USA, 80, 2179, 10.1073/pnas.80.8.2179

Ohsumi, 2001, Molecular dissection of autophagy: two ubiquitin-like systems, Nat. Rev. Mol. Cell Biol., 2, 211, 10.1038/35056522

Petiot, 2000, Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells, J. Biol. Chem., 275, 992, 10.1074/jbc.275.2.992

Rando, 1994, Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy, J. Cell Biol., 125, 1275, 10.1083/jcb.125.6.1275

Rock, 1994, Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules, Cell, 78, 761, 10.1016/S0092-8674(94)90462-6

Sacheck, 2004, IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1, Am. J. Physiol. Endocrinol. Metab., 287, E591, 10.1152/ajpendo.00073.2004

Sacheck, 2007, Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases, FASEB J., 21, 140, 10.1096/fj.06-6604com

Sandri, 2004, Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy, Cell, 117, 399, 10.1016/S0092-8674(04)00400-3

Sandri, 2006, PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription, Proc. Natl. Acad. Sci. USA, 103, 16260, 10.1073/pnas.0607795103

Sarkar, 2007, Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein, J. Biol. Chem., 282, 5641, 10.1074/jbc.M609532200

Schiaffino, 1972, Studies on the effect of denervation in developing muscle. II. The lysosomal system, J. Ultrastruct. Res., 39, 1, 10.1016/S0022-5320(72)80002-9

Scott, 1998, Delivery of proteins and organelles to the vacuole from the cytoplasm, Curr. Opin. Cell Biol., 10, 523, 10.1016/S0955-0674(98)80068-9

Seglen, 1983, Inhibitors of lysosomal function, Methods Enzymol., 96, 737, 10.1016/S0076-6879(83)96063-9

Seglen, 1982, 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes, Proc. Natl. Acad. Sci. USA, 79, 1889, 10.1073/pnas.79.6.1889

Solomon, 1996, Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts, J. Biol. Chem., 271, 26690, 10.1074/jbc.271.43.26690

Stitt, 2004, The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors, Mol. Cell, 14, 395, 10.1016/S1097-2765(04)00211-4

Tassa, 2003, Class III phosphoinositide 3-kinase-Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes, Biochem. J., 376, 577, 10.1042/bj20030826

Tran, 2003, The many forks in FOXO's road, Sci. STKE, 2003, RE5, 10.1126/stke.2003.172.re5

Woo, 1992, Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification, J. Antibiot. (Tokyo), 45, 1108, 10.7164/antibiotics.45.1108

Yamamoto, 2006, Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway, J. Cell Biol., 172, 719, 10.1083/jcb.200510065

Yang, 2004, Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt, Cancer Res., 64, 4394, 10.1158/0008-5472.CAN-04-0343