Five New Diterpenoids from an Okinawan Soft Coral, Cespitularia sp.

Marine Drugs - Tập 10 Số 12 - Trang 2741-2748
Prodip K. Roy1, Wilmar Maarisit1, Michael C. Roy2, Junsei Taira3, Katsuhiro Ueda1
1Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara-cho, Okinawa 903-2013, Japan
2Biological Resources Section, Research Support Division, Okinawa Institute of Science and Technology, Okinawa 904-0495, Japan
3Department of Bioresource Technology, Okinawa National College of Technology, Nago-shi, Okinawa 905-2192, Japan

Tóm tắt

Five new diterpenoids 1–5 were isolated from an Okinawan soft coral, Cespitularia sp., together with the known diterpenoid, alcyonolide (6). New diterpenoid structures were elucidated by spectroscopic methods and by comparison of their NMR data with those of related compounds. Alcyonolide (6) was cytotoxic against HCT 116 cells (IC50 5.85 μM), while these new diterpenoids 1–5 were much less active (IC50 28.2–91.4 μM).

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