Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

Nutrition - Tập 16 Số 3 - Trang 202-208 - 2000
Francis P. Kuhajda1
1From the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Boyd, 1992, Dietary fat and breast cancer risk, Lipids, 27, 821, 10.1007/BF02535857

Risch, 1994, Dietary fat intake and risk of epithelial ovarian cancer, J Natl Cancer Inst, 86, 1409, 10.1093/jnci/86.18.1409

Risch, 1996, Differences in risk factors for epithelial ovarian cancer by histologic type, Am J Epidemiol, 144, 363, 10.1093/oxfordjournals.aje.a008937

Carroll, 1992, Dietary fat and breast cancer, Lipids, 27, 793, 10.1007/BF02535852

Reddy, 1992, Dietary fat and colon cancer, Lipids, 27, 807, 10.1007/BF02535855

Kuhajda, 1994, Fatty acid synthesis, Proc Natl Acad Sci USA, 91, 6379, 10.1073/pnas.91.14.6379

Greenstein, 1954

Medes, 1953, Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro, Cancer Res, 13, 27

Warburg, 1924, Uber den stoffwechsel der carcinomzelle, Biochem Z, 152, 309

Nakashima, 1984, Contributions of glycolysis and oxidative phosphorylation to adenosine 5′-triphosphate production in AS-30D hepatoma cells, Cancer Res, 44, 5702

Bustamante, 1981, Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding, J Biol Chem, 256, 8699, 10.1016/S0021-9258(19)68900-3

Pedersen, 1978, Tumor mitochondria and the bioenergetics of cancer cells, Prog Exp Tumor Res, 22, 190, 10.1159/000401202

Nakashima, 1986, The role of mitochondrial hexodinase binding in the abnormal energy metabolism of tumor cells lines, Ann NY Acad Sci, 488, 438, 10.1111/j.1749-6632.1986.tb46577.x

Nakashima, 1988, Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line, Cancer Res, 48, 913

Arora, 1992, Hexokinase receptors, J Bioenerget Biomembr, 24, 47, 10.1007/BF00769530

Medes, 1953, Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro, Cancer Res, 13, 27

Ookhtens, 1984, Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor, Am J Physiol, 247, R146

Goodridge, 1991

Weiss, 1986, Fatty-acid biosynthesis in man, a pathway of minor importance, Biol Chem, 367, 905

Wakil, 1989, Fatty acid synthase, a proficient multifunctional enzyme, Biochemistry, 28, 4523, 10.1021/bi00437a001

Smith, 1994, The animal fatty acid synthase, FASEB J, 8, 1248, 10.1096/fasebj.8.15.8001737

Magnuson, 1993, Regulation of fatty acid biosynthesis in Escherichia coli, Microbiol Rev, 57, 522, 10.1128/mr.57.3.522-542.1993

Hopwood, 1990, Molecular genetics of polyketides and its comparison to fatty acid biosynthesis, Annu Rev Genet, 24, 37, 10.1146/annurev.ge.24.120190.000345

Dehesh, 1998, Kas IV, Plant J, 15, 383, 10.1046/j.1365-313X.1998.00218.x

Rastogi, 1998, Synergistic activities of antituberculous drugs with cerulenin and trans-cinnamic acid against Mycobacterium tuberculosis, FEMS Immunol Med Microbiol, 21, 149, 10.1111/j.1574-695X.1998.tb01161.x

Mdluli, 1998, Inhibition of Mycobacterium tuberculosis β-ketoacyl ACP synthase by isoniazid, Science, 283, 1607, 10.1126/science.280.5369.1607

Cook, 1991

Christie, 1981, The effects of cerulenin on lipid metabolism in vitro in cellular preparations from the rat, Biochim Biophys Acta, 666, 284, 10.1016/0005-2760(81)90118-1

Saddik, 1993, Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart, J Biol Chem, 268, 25836, 10.1016/S0021-9258(19)74465-2

Alo, 1996, Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients, Cancer, 77, 474, 10.1002/(SICI)1097-0142(19960201)77:3<474::AID-CNCR8>3.0.CO;2-K

Bobrow, 1994, The expression of fatty acid synthase in primary breast cancer, J Pathol, 172, 125a

Jensen, 1995, The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-1 in node-negative breast cancer, J Pathol, 176, 343, 10.1002/path.1711760405

Alo, 1999, Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas, Tumori, 85, 35, 10.1177/030089169908500108

Epstein, 1995, OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate, Urology, 45, 81, 10.1016/S0090-4295(95)96904-7

Shurbaji, 1996, Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer, Hum Pathol, 27, 917, 10.1016/S0046-8177(96)90218-X

Rashid, 1997, Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia, Am J Pathol, 150, 201

Pizer, 1998, Fatty acid synthase expression in endometrial carcinoma, Cancer, 83, 528, 10.1002/(SICI)1097-0142(19980801)83:3<528::AID-CNCR22>3.0.CO;2-X

Gansler, 1997, Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival, Hum Pathol, 28, 686, 10.1016/S0046-8177(97)90177-5

Vlad, 1999, Fatty acid synthase is highly expressed in aggressive thyroid tumors, Mod Pathol, 12, 70A

Kuhajda FP, Pasternack GR, et al. Cancer related antigen. U.S. Patent No. 5,864,001, 1999

Milgraum, 1997, Enzymes of the fatty acid synthesis pathway are highly expressed in situ breast carcinoma, Clin Cancer Res, 3, 2115

Krontiras, 1997, Fatty acid synthase overexpression correlated with malignant phenotype in carcinomas of the oral tongue, Proc Annu Meet Am Assoc Cancer Res, 38, A3629

Omura, 1976, The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis, Bact Rev, 40, 681, 10.1128/br.40.3.681-697.1976

Funabashi, 1989, Binding site of cerulenin in fatty acid synthetase, J Biochem, 105, 751, 10.1093/oxfordjournals.jbchem.a122739

Moche, 1999, Structure of the complex between the antibiotic cerulenin and its target, β-ketoacyl-acyl carrier protein synthase, J Biol Chem, 274, 6031, 10.1074/jbc.274.10.6031

Pizer, 1996, Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer, Cancer Res, 56, 1189

Pizer, 1998, Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines, Cancer Res, 58, 4611

Pizer, 1996, Fatty acid synthase (FAS), Cancer Res, 1996, 745

Furuya, 1997, Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesis, Anticancer Res, 17, 4589

Pizer, 1996, Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells, Cancer Res, 56, 2745

Paulauskis, 1988, Cloning and expression of mouse fatty acid synthase and other specific mRNAs. Developmental and hormonal regulation in 3T3-L1 cells, J Biol Chem, 263, 7049, 10.1016/S0021-9258(18)68602-8

Moustaid, 1991, Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine, J Biol Chem, 266, 18550, 10.1016/S0021-9258(18)55097-3

Paulauskis, 1989, Hormonal regulation of mouse fatty acid synthase gene transcription in liver, J Biol Chem, 264, 574, 10.1016/S0021-9258(17)31298-X

Kinlaw, 1995, Direct evidence for a role of the “spot 14” protein in the regulation of lipid synthesis, J Biol Chem, 270, 16615, 10.1074/jbc.270.28.16615

Volpe, 1975, Hormonal regulation and fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver, Biochim Biophys Acta, 380, 454, 10.1016/0005-2760(75)90113-7

Clarke, 1993, Regulation of gene transcription by polyunsaturated fatty acids, Prog Lipid Res, 32, 139, 10.1016/0163-7827(93)90013-M

Blake, 1990, Suppression of rat hepatic fatty acid synthase and S14 gene transcription by dietary polyunsaturated fat, J Nutr, 120, 1727, 10.1093/jn/120.12.1727

Jump, 1994, Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids, J Lipid Res, 1994, 1076, 10.1016/S0022-2275(20)40103-8

Cohen, 1998, 13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism, Proc Natl Acad Sci USA, 95, 7385, 10.1073/pnas.95.13.7385

Jones, 1996, Upregulation of adipocyte metabolism by agouti protein, Am J Physiol, 270, E192

Kalkhoven, 1994, Synthetic progestins induce proliferation of breast tumor cell lines via the progesterone or estrogen receptor, Mol Cell Endocrinol, 102, 45, 10.1016/0303-7207(94)90096-5

Chalbos, 1990, Regulation of fatty acid synthetase by progesterone in normal and tumoral human mammary glands, Rev Esp Fisiol, 46, 43

Escot, 1990, Regulation of fatty acid synthetase ribonucleic acid in the human endometrium during the menstrual cycle, J Clin Endocrinol Metab, 70, 1319, 10.1210/jcem-70-5-1319

Teruel, 1995, Transforming growth factor β1 induces differentiation-specific gene expression in fetal rat brown adipocytes, FEBS Lett, 364, 193, 10.1016/0014-5793(95)00385-M

Bennett, 1995, Sterol regulation of fatty acid synthase promotor, J Biol Chem, 270, 25578, 10.1074/jbc.270.43.25578

Moustaid, 1994, Identification of an insulin response element in the fatty acid synthase promotor, J Biol Chem, 269, 5629, 10.1016/S0021-9258(17)37507-5

Wang, 1998, Insulin stimulation of the fatty acid synthase promotor is mediated by the phosphatidylinositol 3-kinase pathway, J Biol Chem, 273, 25420, 10.1074/jbc.273.39.25420

Rangan, 1996, Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as a essential element for mediation of transcriptional regulation by cAMP, J Biol Chem, 271, 2307, 10.1074/jbc.271.4.2307

Hsu, 1996, Human fatty-acid synthase gene, J Biol Chem, 271, 13584, 10.1074/jbc.271.23.13584

Swinnen, 1996, Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP, Endocrinology, 137, 4468, 10.1210/endo.137.10.8828509

Swinnen, 1997, Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP, Cancer Res, 57, 1086

Swinnen, 1997, Coordinate regulation of lipogenic gene expression by androgens, Proc Natl Acad Sci USA, 94, 12975, 10.1073/pnas.94.24.12975

Hsu, 1993, Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and CA2+-ATPase mRNA expression in NIH 3T3 cells, Biochem Biophys Res Commun, 197, 1483, 10.1006/bbrc.1993.2644

Pizer, 1996, Expression of fatty acid synthase is closely linked to proliferation and stromal decidualization in cycling endometrium, Int J Gynecol Pathol, 16, 45, 10.1097/00004347-199701000-00008