Expression and Proteolysis of Vascular Endothelial Growth Factor is Increased in Chronic Wounds

Journal of Investigative Dermatology - Tập 115 Số 1 - Trang 12-18 - 2000
Gereon Lauer1, Stephan Sollberg1, Melanie Cole1, Thomas Krieg1, Sabine A. Eming1, Ingo Flamme2, J Stürzebecher3, Karlheinz Mann4
1Department of Dermatology, University of Cologne, Cologne, Germany
2Center for Molecular Medicine Cologne, Germany
3Center for Vascular Biology and Medicine, Friedrich-Schiller-University Jena, Erfurt, Germany
4Max Planck Institute of Biochemistry, Martinsried, Germany

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Brown, 1995, Expression of VEGF in bullous pemphigoid, dermatitis herpitiformis, and erythema multiforme, J Invest Dermatol, 104, 744, 10.1111/1523-1747.ep12606974

Brown, 1995, Overexpression of VEGF and its endothelial cell receptors in delayed hypersensitivity skin reactions, J Immunol, 154, 2801, 10.4049/jimmunol.154.6.2801

Brown, 1992, Expression of VEGF by epidermal keratinocytes during wound healing, J Exp Med, 176, 1375, 10.1084/jem.176.5.1375

Bullen, 1995, TIMP-1 is decreased and activated gelatinases are increased in chronic wounds, J Invest Deramtol, 104, 236, 10.1111/1523-1747.ep12612786

Detmar, 1997, Hypoxia regulates the expression of VPF/VEGF and its receptors in human skin, J Invest Dermatol, 108, 263, 10.1111/1523-1747.ep12286453

Detmar, 1994, Overexpression of VEGF and its receptors in psoriasis, J Exp Med, 180, 1141, 10.1084/jem.180.3.1141

Detmar, 1998, Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of vEGF transgenic mice, J Invest Drmatol, 111, 1, 10.1046/j.1523-1747.1998.00262.x

Detmar, 1995, Keratinocyte-derived VEGF is a potent mitogen for dermal microvascular endothelial cells, J Invest Dermatol, 105, 44, 10.1111/1523-1747.ep12312542

Dvorak, 1995, VPF/VEGF, microvascular hypermeability, and angiogenesis, Am J Path, 146, 1029

Falanga, 1993, Chronic wounds: pathophysiologic and experimental considerations, J Invest Dermatol, 100, 721, 10.1111/1523-1747.ep12472373

Flamme, 1998, Up-regulation of VEGF in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha, Am J Path, 153, 25, 10.1016/S0002-9440(10)65541-1

Frank, 1995, Reulation of the VEGF expression in cultured keratinocytes, J Biol Chem, 270, 12607, 10.1074/jbc.270.21.12607

Franzeck, 1984, Transcutaneous oxygen tension and capillary morphologic characteristics and density in patients with chronic venous incompetence, Circulation, 70, 806, 10.1161/01.CIR.70.5.806

Fukumura, 1998, Tumor induction of VEGF promotor activity in stromal cells, Cell, 94, 715, 10.1016/S0092-8674(00)81731-6

Gille, 1998, HGF/SF induces VPF/VEGF expression by cultured keratinocytes, J Invest Dermatol, 111, 1160, 10.1046/j.1523-1747.1998.00418.x

Grinnell, 1992, Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, cell adhesion assays, J Invest Dermatol, 98, 410, 10.1111/1523-1747.ep12499839

Grinnell, 1996, Fibronectin degradation in chronic wounds depends on the relative levels of elastase, a1-proteinase inhibitor, and a2-macroglobulin, J Invest Dermatol, 106, 335, 10.1111/1523-1747.ep12342990

Herrick, 1992, Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers, Am J Path, 141, 1085

Hoffman, 1998, Wound fluid from venous leg ulcers degrades plasminogen and reduces plasmin generation by keratinocytes, J Invest Deramtol, 111, 1140, 10.1046/j.1523-1747.1998.00429.x

Houck, 1991, The VEGF familiy: identification of a fourth molecular species and characterization of alternative splicing RNA, Mol Endocrinol, 5, 1806, 10.1210/mend-5-12-1806

Houck, 1992, Dual regulation of VEGF bioavailability by genetic and proteolytic mechanisms, J Biol Chem, 267, 26031, 10.1016/S0021-9258(18)35712-0

Keyt, 1996, The carboxyl-terminal domain (111–165) of VEGF is critical for its mitogenic potency, J Biol Chem, 271, 7788, 10.1074/jbc.271.13.7788

Kuus, 1992, Tissue-type plasminogen activator-mediated activation of plasminogen on the surface of group A, C and G streptococci, Infect Immun, 60, 196, 10.1128/IAI.60.1.196-201.1992

Kuusela, 1990, Binding and activation of plasminogen at the surface of Staphylococcus aureus. Increase in affinity after conversion the Lys form of the ligand, Eur J Biochem, 193, 759, 10.1111/j.1432-1033.1990.tb19397.x

Lei, 1998, Identification and characterization of a new splicing variant of VEGF.VEGF183, Biochem Biophys Acta, 1443, 400

Leu, 1991, Morphology of chronic venous insufficiency – light and electronic microscopic examinations, VASA, 20, 330

Leu, 1995, Microvascular changes in chronic venous insufficiency – a review, Cardiovasc Surg, 3, 237, 10.1016/0967-2109(95)93871-L

Luetolf, 1993, Capillary underperfusion in chronic venous insufficiency: a cause for leg ulceration?, Br J Dermatol, 128, 249, 10.1111/j.1365-2133.1993.tb00166.x

Matsudaira, 1987, Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes, J Biol Chem, 262, 10035, 10.1016/S0021-9258(18)61070-1

Nissen, 1998, VEGF mediates angiogenic activity during the proliferative phase of wound healing, Am J Path, 152, 1445

Palolathi, 1993, Proteolytic activity in leg exudate, Exp Dermatol, 2, 29, 10.1111/j.1600-0625.1993.tb00196.x

Plouet, 1997, Extracellular cleavage of the VEGF 189-amino acid form by urokinase is required for its mitogenic effect, J Biol Chem, 272, 13390, 10.1074/jbc.272.20.13390

Rao, 1995, α1-antitrypsin is degraded and non-functional in chronic wounds but intact and functional in acute wounds, J Invest Dermatol, 105, 572, 10.1111/1523-1747.ep12323503

Risau, 1997, Mechanisms of angiogenesis, Nature, 386, 671, 10.1038/386671a0

Scelsi, 1994, Morphological changes of dermal blood and lymphatic vessels in chronic venous insufficiency of the leg, Intern Angiol, 13, 308

Schäfer, 1995, Differential expression of uPA, ist receptor (uPA-R), and inhibitor type-2 (PAI-2) during differentiation of keratinocytes in an organotypic coculture system, Exp Cell Res, 220, 415, 10.1006/excr.1995.1333

Soker, 1997, Inhibition of VEGF-induced endothelial cell proliferation by a peptide correspondig to the exon 7-encoded domain of VEGF165, J Biol Chem, 272, 31582, 10.1074/jbc.272.50.31582

Soker, 1998, Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for VEGF, Cell, 92, 735, 10.1016/S0092-8674(00)81402-6

Stürzebecher, 1995, Structure-activity relationships of inhibitors derived from 3-amidinophenylalanine, J Enzyme Inhibition, 9, 87, 10.3109/14756369509040683

Stürzebecher, 1996, 3-Amidinophenylalanine-derivates as inhibitors of enzymes of the fibrinolytic system, Ann Hematol, 72, A33

Tischer, 1991, The human gene for VEGF, J Biol Chem, 266, 11947, 10.1016/S0021-9258(18)99049-6

Vaalamo, 1997, Distinct populations of stromal cells express MMP-13 and MMP-1 in chronic ulcers but not in normally healing wounds, J Invest Dermatol, 109, 96, 10.1111/1523-1747.ep12276722

Weckroth, 1996, Matrix metalloproteinases, gelatinases and collagenase in chronic leg ulcers, J Invest Dermatol, 106, 1119, 10.1111/1523-1747.ep12340167

Wlaschek, 1997, Protease inhibitors protect growth factor activity in chronic wounds, Br J Dermatol, 137, 646, 10.1111/j.1365-2133.1997.tb03804.x

Yager, 1996, Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluid, J Invest Dermatol, 107, 743, 10.1111/1523-1747.ep12365637