Exploring Aztreonam in Combination with Ceftazidime-Avibactam or Meropenem-Vaborbactam as Potential Treatments for Metallo- and Serine-β-Lactamase-Producing Enterobacteriaceae

Antimicrobial Agents and Chemotherapy - Tập 63 Số 12 - 2019
Mark Biagi1, Ting Wu1, Migyung Lee1, Shitalben Patel1, David A. Butler1, Eric Wenzler1
1College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

Tóm tắt

Metallo-β-lactamase (MBL)-producing Enterobacteriaceae , particularly those that coharbor serine β-lactamases, are a serious emerging public health threat given their rapid dissemination and the limited number of treatment options. Preclinical and anecdotal clinical data support the use of aztreonam in combination with ceftazidime-avibactam against these pathogens, but other aztreonam-based combinations have not been explored.

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Antimicrobial Agents and Chemotherapy

Tập 63 Số 12

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