Experimental studies on benzene carcinogenicity at the bologna institute of oncology: Current results and ongoing research

American Journal of Industrial Medicine - Tập 7 Số 5-6 - Trang 415-446 - 1985
C Maltoni1, Bárbara Conti1, Giuliano Cotti1, Fiorella Belpoggi1
1Institute of Oncology, Bologna, Italy

Tóm tắt

AbstractIn 1977 Maltoni and Scarnato were the first to demonstrate that benzene is an experimental carcinogen in rats. With that and other experiments, Maltoni et al have shown that benzene administered by ingestion (stomach tube) or inhalation is a multipotential carcinogen in rats (of two different strains) and mice and produces a variety of tumors, namely: Zymbal gland carcinomas, oral and nasal cavity carcinomas, skin carcinomas, acanthomas, dysplasias and carcinomas of forestomach, mammary malignant tumors, hepatomas, liver angiosarcomas, hemolymphoreticular neoplasias, and pulmonary tumors. The incidence of Zymbal gland carcinomas and carcinomas of the oral and nasal cavitities is affected by the length of treatment by inhalation and by the age of animals. However, the available epidemiological and experimental data at present do not provide precise information on the risk of doses around or below 10 ppm. Long‐term carcinogenicity bioassays at 50, 25, 10, 5 and 1 ppm may be helpful for scientific risk assessment. In addition, these experiments have shown that toluene, xylene, and ethylbenzene, at high concentrations, cause an increase in the number of total malignant tumors.

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Tài liệu tham khảo

Delore P, 1928, Leucémie aigües au cours de l'intoxication benzénique. Sur l'origine toxique de certaines leucémies aigües et leurs rélations avec les anémies graves, J Med Lyon, 9, 227

Maltoni C, 1982, Benzene: A multipotential carcinogen, Acta Oncol, 3, 1

Maltoni C, 1982, Benzene: An experimental multipotential carcinogen

Maltoni C, 1982, Squamous cell carcinomas of the oral cavity in Sprague‐Dawley rats, following exposure to benzene by ingestion. First experimental demonstration, Med Lav, 73, 441

10.1002/ajim.4700030104

Maltoni C, 1982, Hepatocarcinomas in Sprague‐Dawley rats, following exposure to benzene by inhalation. First experimental demonstration, Med Lav, 73, 446

10.1002/ajim.4700040503

Maltoni C, 1983, Benzene as an experimental carcinogen: Up‐to‐date evidence, Acta Oncol, 4, 141

Maltoni C, 1977, Le prime prove sperimentali della azione cancerogena del benzene, Osp Vita, 4, 111

Maltoni C, 1979, First experimental demonstration of the carcinogenic effects of benzene. Long‐term bioassays on Sprague‐Dawley rats by oral administration, Med Lav, 70, 352

Maltoni C, 1981, Tossicologia e Patologia da Benzene

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Thông tin xuất bản

American Journal of Industrial Medicine

Tập 7 Số 5-6

415-446

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