Experiencing community and domestic violence is associated with epigenetic changes in DNA methylation of BDNF and CLPX in adolescents

Psychophysiology - Tập 57 Số 1 - 2020
Fernanda Serpeloni1,2, Daniel Nätt3, Simone Gonçalves de Assis2, Elizabeth Wieling4, Thomas Elbert1
1Clinical Psychology and Neuropsychology, Department of Psychology, University of Konstanz, Konstanz, Germany
2National School of Public Health of Rio de Janeiro and National Institute of Women, Children and Adolescents' Health Fernandes Figueira, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
3Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden
4Family Social Science, University of Minnesota, Minneapolis and St. Paul, Minnesota

Tóm tắt

Abstract

Experiencing violence changes behavior, shapes personalities, and poses a risk factor for mental disorders. This association might be mediated through epigenetic modifications that affect gene expression, such as DNA methylation. The present study investigated the impact of community and domestic violence on DNA methylation measured in saliva collected from 375 individuals including three generations: grandmothers (n = 126), mothers (n = 125), and adolescents (n = 124, 53% female). Using the Infinium HumanMethylation450 BeadChip array, in adolescents, we detected two CpG sites that showed an association of DNA methylation and lifetime exposure to community and domestic violence even after FDR correction: BDNF_cg06260077 (logFC −0.454, p = 3.71E‐07), and CLPX_cg01908660 (logFC = −0.372, p = 1.38E‐07). Differential DNA methylation of the CpG BDNF_cg06260077 associated with exposure to violence was also observed in the maternal but not the grandmaternal generation. BDNF (brain‐derived neurotrophic factor) and CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) genes are involved in neural development. Our results thus reveal altered molecular mechanisms of developmental and intergenerational trajectories in survivors of repeated violent experiences.

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Psychophysiology

Tập 57 Số 1

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