Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

Cytotherapy - Tập 17 Số 7 - Trang 932-939 - 2015
Akvilė Jarmalavičiūtė1,2, Virginijus Tunaitis2, Ugnė Jonavičė2, Algirdas Venalis2, Augustas Pivoriūnas2
1Department of Neurobiology and Biophysics, Faculty of Natural Sciences, Vilnius University, Vilnius, Lithuania
2Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

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Bianco, 2013, The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine, Nat Med, 19, 35, 10.1038/nm.3028

Ankrum, 2010, Mesenchymal stem cell therapy: Two steps forward, one step back, Trends Mol Med, 16, 203, 10.1016/j.molmed.2010.02.005

Caplan, 2009, Why are MSCs therapeutic? New data: new insight, J Pathol, 217, 318, 10.1002/path.2469

Lee, 2009, Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6, Cell Stem Cell, 5, 54, 10.1016/j.stem.2009.05.003

Webber, 2010, Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases, J Tissue Eng Regen Med, 4, 600, 10.1002/term.273

Caplan, 2011, The MSC: an injury drugstore, Cell stem cell, 9, 11, 10.1016/j.stem.2011.06.008

Bronckaers, 2014, Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis, Pharmacol Ther, 143, 181, 10.1016/j.pharmthera.2014.02.013

van der Pol, 2012, Classification, functions, and clinical relevance of extracellular vesicles, Pharmacol Rev, 64, 676, 10.1124/pr.112.005983

Ratajczak, 2006, Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery, Leukemia, 20, 847, 10.1038/sj.leu.2404132

Raposo, 2013, Extracellular vesicles: exosomes, microvesicles, and friends, J Cell Biol, 200, 373, 10.1083/jcb.201211138

Batouli, 2003, Comparison of Stem-cell-mediated Osteogenesis and Dentinogenesis, J Dent Res, 82, 976, 10.1177/154405910308201208

Dellavalle, 2011, Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells, Nat Commun, 2, 499, 10.1038/ncomms1508

Santagati, 2003, Cranial neural crest and the building of the vertebrate head, Nature Rev Neurosci, 4, 806, 10.1038/nrn1221

Arthur, 2008, Adult human dental pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues, Stem Cells (Dayton, Ohio), 26, 1787, 10.1634/stemcells.2007-0979

Király, 2009, Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons, Neurochem Int, 55, 323, 10.1016/j.neuint.2009.03.017

Huang, 2008, Putative dental pulp-derived stem/stromal cells promote proliferation and differentiation of endogenous neural cells in the hippocampus of mice, Stem Cells (Dayton, Ohio), 26, 2654, 10.1634/stemcells.2008-0285

Sakai, 2012, Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms, J Clin Invest, 122, 80

Nosrat, 2001, Dental pulp cells produce neurotrophic factors, interact with trigeminal neurons in vitro, and rescue motoneurons after spinal cord injury, Dev.Biol, 238, 120, 10.1006/dbio.2001.0400

Nosrat, 2004, Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system, Eur J Neurosci, 19, 2388, 10.1111/j.0953-816X.2004.03314.x

Donato, 2007, Differential development of neuronal physiological responsiveness in two human neural stem cell lines, BMC Neurosci, 8, 36, 10.1186/1471-2202-8-36

Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006;Chapter 3:Unit 3.22.

Alvarez-Erviti, 2011, Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes, Nat Biotechnol, 29, 341, 10.1038/nbt.1807

Lotharius, 1999, Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons, J Neurosci, 19, 1284, 10.1523/JNEUROSCI.19-04-01284.1999

Mazzio, 2004, The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro, Brain research, 1004, 29, 10.1016/j.brainres.2003.12.034

Zhou, 2013, Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro, Stem Cell Res Ther, 4, 34, 10.1186/scrt194

Sreekumar, 2010, αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells, PLoS One, 5, e12578, 10.1371/journal.pone.0012578