Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

European Journal of Immunology - Tập 18 Số 11 - Trang 1797-1802 - 1988
Toshio Hirano1, Tadashi Matsuda1, Martin Turner2, Nobuyuki Miyasaka3, Glenn Buchan2, Bo Tang3, Kazuto Sato3, Masatoshi Shimi4, Ravinder Maid5, Marc Feldmann2, Tadamitsu Kishimoto1
1Division of Immunology, Institute for Molecular and Cellular Biology, Osaka University, Tokyo
2The Charin Cross Sunley Research Centre, Tokyo
3Woman's Medical College, Tokyo
4Osaka-Minami National Hospital, Osaka
5Hammersmith and Kennedy Institute for Rheumatology+, Tokyo

Tóm tắt

Abstract

High levels of interleukin 6 (IL 6/B cell stimulatory factor‐2) were detected in synovial fluids from the joints of patients with active rheumatoid arthritis (RA). The cells found in freshly isolated synovial fluid constitutively expressed IL6 mRNA. The synovial tissues obtained by joint biopsy were also found to produce IL6 in vitro. Immunohistochemical analysis demonstrated that CD2+ T cells as well as CD20+ blastoid B cells in the synovial tissues produce IL6. The data indicate that IL6 is generated constitutively in RA and its overproduction may explain the local as well as the generalized symptoms of RA, since IL6 can function as B cell growth and differentiation factor as well as hepatocyte‐stimulating factor.

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European Journal of Immunology

Tập 18 Số 11

1797-1802

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