Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans

2001, Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care., Crit Care Med, 29, 1303, 10.1097/00003246-200107000-00002

2003, The epidemiology of sepsis in the United States from 1979 through 2000., N Engl J Med, 348, 1546, 10.1056/NEJMoa022139

1996, Bacteremia and severe sepsis in adults: A multicenter prospective survey in ICUs and wards of 24 hospitals. French Bacteremia-Sepsis Study Group., Am J Respir Crit Care Med, 154, 617, 10.1164/ajrccm.154.3.8810595

1995, Clinical risks for development of the acute respiratory distress syndrome., Am J Respir Crit Care Med, 151, 293, 10.1164/ajrccm.151.2.7842182

1994, Report of the American-European Consensus Conference on acute respiratory distress syndrome: Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee., J Crit Care, 9, 72, 10.1016/0883-9441(94)90033-7

1995, Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983–1993., JAMA, 273, 306, 10.1001/jama.1995.03520280052039

The Acute Respiratory Distress Syndrome Network, 2000, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome., N Engl J Med, 342, 1301, 10.1056/NEJM200005043421801

1995, Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation., J Cell Physiol, 163, 510, 10.1002/jcp.1041630311

1995, Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities., Am J Physiol, 269, L99

2004, Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns., Am J Physiol Lung Cell Mol Physiol, 286, L841, 10.1152/ajplung.00341.2003

1996, Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning., Cell, 87, 1161, 10.1016/S0092-8674(00)81812-7

1997, Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis., Science, 277, 55, 10.1126/science.277.5322.55

1999, Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors., Lab Invest, 79, 213

2003, Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor., FASEB J, 17, 1609, 10.1096/fj.02-0939com

2004, Opposing effect of angiopoietin-1 on VEGF-mediated disruption of endothelial cell–cell interactions requires activation of PKC beta., J Cell Physiol, 198, 53, 10.1002/jcp.10386

2001, Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression., Circ Res, 89, 477, 10.1161/hh1801.097034

2000, Angiopoietin-1 protects the adult vasculature against plasma leakage., Nat Med, 6, 460, 10.1038/74725

2001, Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia., Am J Respir Crit Care Med, 164, 1971, 10.1164/ajrccm.164.10.2101140

1997, Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues., Circ Res, 81, 567, 10.1161/01.RES.81.4.567

2004, A gene atlas of the mouse and human protein-encoding transcriptomes., Proc Natl Acad Sci U S A, 101, 6062, 10.1073/pnas.0400782101

2003, 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference., Crit Care Med, 31, 1250, 10.1097/01.CCM.0000050454.01978.3B

2000, Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability., Am J Physiol Cell Physiol, 279, C1285, 10.1152/ajpcell.2000.279.4.C1285

2004, Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure., J Am Coll Cardiol, 43, 423, 10.1016/j.jacc.2003.08.042

2000, The acute respiratory distress syndrome., N Engl J Med, 342, 1334, 10.1056/NEJM200005043421806

1994, Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli., Am J Physiol, 266, L61

1999, Endothelial gaps as sites for plasma leakage in inflammation., Microcirculation, 6, 7, 10.1080/713773924

2002, Intracellular signalling involved in modulating human endothelial barrier function., J Anat, 200, 549, 10.1046/j.1469-7580.2002.00060.x

1990, Involvement of myosin light-chain kinase in endothelial cell retraction., Proc Natl Acad Sci U S A, 87, 16, 10.1073/pnas.87.1.16

1993, Role of myosin light-chain phosphorylation in endothelial cell retraction., Am J Physiol, 265, L606

2003, Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment., Proc Natl Acad Sci U S A, 100, 6233, 10.1073/pnas.1031595100

1985, Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase., J Biol Chem, 260, 10027, 10.1016/S0021-9258(17)39206-2

1994, Mutagenesis of the phosphorylation site (serine 19) of smooth muscle myosin regulatory light chain and its effects on the properties of myosin., Biochemistry, 33, 840, 10.1021/bi00169a027

1998, Rho GTPases and the actin cytoskeleton., Science, 279, 509, 10.1126/science.279.5350.509

1996, Identification of a putative target for Rho as the serine-threonine kinase protein kinase N., Science, 271, 648, 10.1126/science.271.5249.648

1996, Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)., Science, 273, 245, 10.1126/science.273.5272.245

1997, Signaling vascular morphogenesis and maintenance., Science, 277, 48, 10.1126/science.277.5322.48

1984, Production and antagonism of cutaneous vascular permeability in the guinea pig in response to histamine, leukotrienes and A23187., J Pharmacol Exp Ther, 230, 550

1988, Transvascular flux and tissue accrual of Evans blue: Effects of endotoxin and histamine., J Lab Clin Med, 111, 173

2005, Pathophysiological consequences of VEGF-induced vascular permeability., Nature, 437, 497, 10.1038/nature03987

1981, Sensitivity of scintigraphy for detection of pulmonary capillary albumin leak in canine oleic acid ARDS., J Trauma, 21, 520, 10.1097/00005373-198107000-00003

1982, Comparative scintigraphy in oleic acid pulmonary microvascular injury., Crit Care Med, 10, 31, 10.1097/00003246-198201000-00008

1984, Gamma scintigraphic analysis of albumin flux in patients with acute respiratory distress syndrome., Surgery, 95, 674

1988, Pulmonary vascular permeability during the adult respiratory distress syndrome: A positron emission tomographic study., Am Rev Respir Dis, 138, 421, 10.1164/ajrccm/138.2.421

1998, The 67gallium-transferrin pulmonary leak index in patients at risk for the acute respiratory distress syndrome., Crit Care Med, 26, 685, 10.1097/00003246-199804000-00016

2003, Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide., Am J Pathol, 162, 1927, 10.1016/S0002-9440(10)64326-X

2005, Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins., Circ Res, 96, e8

1989, Tumor necrosis factor and interleukin 1 alpha increase vascular endothelial permeability., Am J Physiol, 257, L399

1988, IL-1 and IFN-gamma increase vascular permeability., Immunology, 64, 301

2002, C1-inhibitor in patients with severe sepsis and septic shock: Beneficial effect on renal dysfunction., Crit Care Med, 30, 1722, 10.1097/00003246-200208000-00008

2005, Protective role of angiopoietin-1 in endotoxic shock., Circulation, 111, 97, 10.1161/01.CIR.0000151287.08202.8E

2005, Angiopoietin-2 causes inflammation in vivo by promoting vascular leakage., J Pharmacol Exp Ther, 314, 738, 10.1124/jpet.105.086553

1999, Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1., Science, 286, 2511, 10.1126/science.286.5449.2511

2001, Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2., Cardiovasc Res, 49, 659, 10.1016/S0008-6363(00)00231-5

2005, Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2., J Cell Biol, 169, 239, 10.1083/jcb.200411105

2004, Hypoxic regulation of angiopoietin-2 expression in endothelial cells., J Biol Chem, 279, 12171, 10.1074/jbc.M305146200

2001, Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats., Am J Physiol Lung Cell Mol Physiol, 281, L582, 10.1152/ajplung.2001.281.3.L582

1998, Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia., Circ Res, 83, 852, 10.1161/01.RES.83.8.852

2005, Plasma vascular endothelial growth factor in severe sepsis., Shock, 23, 35, 10.1097/01.shk.0000150728.91155.41

2004, Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis., Inflammation, 28, 271, 10.1007/s10753-004-6050-3

2004, The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies., Blood, 103, 4150, 10.1182/blood-2003-10-3685

2000, Inhibition of VEGF receptors causes lung cell apoptosis and emphysema., J Clin Invest, 106, 1311, 10.1172/JCI10259