Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum

Breen, 2011, Multisite comparison of high-sensitivity multiplex cytokine assays, Clin. Vaccine Immunol., 18, 1229, 10.1128/CVI.05032-11 de Koning, 2012, A multiplex immunoassay gives different results than singleplex immunoassays which may bias epidemiologic associations, Clin. Biochem., 45, 848, 10.1016/j.clinbiochem.2012.04.006 DeSilva, 2003, Recommendations for the bioanalytical method validation of ligand-binding assays to support pharmacokinetic assessments of macromolecules, Pharm. Res., 20, 1885, 10.1023/B:PHAM.0000003390.51761.3d Fraser, 2014, Active glucagon-like peptide 1 quantitation in human plasma: a comparison of multiple ligand binding assay platforms, J. Immunol. Methods, 407, 76, 10.1016/j.jim.2014.03.025 Huttunen, 2014, The effect of assay type and sample matrix on detected cytokine concentrations in human blood serum and nasal lavage fluid, J. Pharm. Biomed. Anal., 96, 151, 10.1016/j.jpba.2014.03.034 Iwakura, 2008, The roles of IL-17a in inflammatory immune responses and host defense against pathogens, Immunol. Rev., 226, 57, 10.1111/j.1600-065X.2008.00699.x Kovarova, 1989, Interleukin 2. Biochemical aspects of structure and function. Review, Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove, 397 Leary, 2013, Bioanalytical platform comparison using a generic human IgG PK assay format, J. Immunol. Methods, 397, 28, 10.1016/j.jim.2013.08.009 Locksley, 2001, The TNF and TNF receptor superfamilies: Integrating mammalian biology, Cell, 104, 487, 10.1016/S0092-8674(01)00237-9 Myzithras, 2016, Development of an ultra-sensitive Simoa assay to enable GDF11 detection: a comparison across bioanalytical platforms, Bioanalysis, 8, 511, 10.4155/bio.16.17 Sharma, 2011, IL2: a two-faced master regulator of autoimmunity, J. Autoimmun., 36, 91, 10.1016/j.jaut.2011.01.001 Soderstrom, 2011, Comparison of four distinct detection platforms using multiple ligand binding assay formats, J. Immunol. Methods, 371, 106, 10.1016/j.jim.2011.06.020 Turner, 2014, Cytokines and chemokines: at the crossroads of cell signaling and inflammatory disease, Biochim. Biophys. Acta, 1843, 2563, 10.1016/j.bbamcr.2014.05.014 Valentin, 2011, Validation of immunoassay for protein biomarkers: bioanalytical study plan implementation to support pre-clinical and clinical studies, J. Pharm. Biomed. Anal., 55, 869, 10.1016/j.jpba.2011.03.033 Wolf, 2014, Interleukin-6 and its receptors: a highly regulated and dynamic system, Cytokine, 70, 11, 10.1016/j.cyto.2014.05.024 Wu, 2015, Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples, Analyst, 140, 6277, 10.1039/C5AN01238D