Evaluation of Xpert MTB/RIF testing for rapid diagnosis of childhood pulmonary tuberculosis in children by Xpert MTB/RIF testing of stool samples in a low resource setting

Zahra Hasan1, Sadia Shakoor1, Fehmina Arif2, Aisha Mehnaz2, Alnoor Akber1, Marium Haider2, Akbar Kanji1, Rumina Hasan1
1Department of Pathology and Laboratory Medicine, The Aga Khan University, Karachi, Pakistan
2Department of Pediatrics, Dow University of Health Sciences, Civil Hospital, Karachi, Pakistan

Tóm tắt

Từ khóa


Tài liệu tham khảo

World Health Organization. Global tuberculosis report. Geneva: World Health Organization; 2016.

Mehnaz A, Arif F. Applicability of scoring chart in the early detection of tuberculosis in children. J Coll Physicians Surg Pak. 2005;15(9):543–6.

NTP. National guidelines for diagnosis and management of tuberculosis in children; 2007.

Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N. Xpert(R) MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults. Cochrane Database Syst Rev. 2014;1:CD009593.

Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, et al. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med. 2015;3(6):451–61.

Nicol MP, Spiers K, Workman L, Isaacs W, Munro J, Black F, et al. Xpert MTB/RIF testing of stool samples for the diagnosis of pulmonary tuberculosis in children. Clin Infect Dis. 2013;57(3):e18–21.

Woods GL. Susceptibility testing for mycobacteria. Clin Infect Dis. 2000;31(5):1209–15.

Adminstration FaD. Statistical guidance on reporting results from studies evaluating diagnostic tests; 2007.

Hesseling AC, Schaaf HS, Gie RP, Starke JR, Beyers N. A critical review of diagnostic approaches used in the diagnosis of childhood tuberculosis. Int J Tuberc Lung Dis. 2002;6(12):1038–45.

Bergman NJ. A “treatment score” for primary and pulmonary tuberculosis. Cent Afr J Med. 1995;41(1):1–6.

Shakoor S, Qamar FN, Mir F, Zaidi A, Hasan R. Are TB control programmes in South Asia ignoring children with disease? A situational analysis. Arch Dis Child. 2015;100(2):198–205.

World Health Organization. Global tuberculosis report. Geneva: World Health Organization; 2015.

Chipinduro M, Mateveke K, Makamure B, Ferrand RA, Gomo E. Stool Xpert(R) MTB/RIF test for the diagnosis of childhood pulmonary tuberculosis at primary clinics in Zimbabwe. Int J Tuberc Lung Dis. 2017;21(2):161–6.

Banada PP, Naidoo U, Deshpande S, Karim F, Flynn JL, O’Malley M, et al. A novel sample processing method for rapid detection of tuberculosis in the stool of pediatric patients using the Xpert MTB/RIF assay. PLoS ONE. 2016;11(3):e0151980.

Marcy O, Ung V, Goyet S, Borand L, Msellati P, Tejiokem M, et al. Performance of Xpert MTB/RIF and alternative specimen collection methods for the diagnosis of tuberculosis in HIV-infected children. Clin Infect Dis. 2016;62(9):1161–8.