European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection

Public Health Nutrition - Tập 5 Số 6b - Trang 1113-1124 - 2002
Elio Ríboli1, Kelly J. Hunt2, Nadia Slimani1, Pietro Ferrari1, T. Norat1, Michael Fahey1, U. Ruth Charrondière1, Bertrand Hémon1, Corinne Casagrande1, Jérôme Vignat1, Kim Overvad3, Anne Tjønneland4, F Clavel-Chapelon5, Anne C. M. Thiébaut5, J. Wahrendorf6, Heiner Boeing7, D Trichopoulos8,9, Antonia Trichopoulou9, Paolo Vineis10, Domenico Palli11, HB Bueno-de-Mesquita12, PHM Peeters13, Eiliv Lund14, Dagrun Engeset14, Carlos A. González15, Aurelio Barricarte16, G Berglund17, G. Hallmans18, NE Day19, TJ Key20, Rudolf Kaaks21, Rodolfo Saracci22,1
1Unit of Nutrition and Cancer, International Agency for Research on Cancer (IARC–WHO), 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France
2Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX, USA
3Department of Epidemiology and Social Medicine, University of Aarhus, Denmark
4Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
5INSERM, U521, Institute Gustave Roussy, Villejuif, France
6German Cancer Research Centre, Heidelberg, Germany
7Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany
8Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;
9Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece
10Department of Biomedical Sciences and Human Oncology, University of Turin, Italy.
11Molecular & Nutrition Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy
12Department of Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
13Julius Center for General Practice and Patient Oriented Research, University of Utrecht, The Netherlands
14Institute of Community Medicine, University of Tromsø, , Norway
15Department of Epidemiology Catalan Institute of Oncology, Barcelona, Spain
16Service of Surveillance and Epidemiological Control, Institute of Public Health of Navarra, Pamplona, Spain
17Department of Medicine, Lund University, Malmö University Hospital, Sweden
18Public Health and Clinical Medicine, University Hospital of Northern Sweden, Umeå, Sweden
19Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, UK
20Cancer Research UK Epidemiology Unit, University of, Oxford, UK
21Hormones and Cancer Group, IARC–WHO, Lyon, France
22Division of Epidemiology, IFC, National Research Council, Pisa, Italy

Tóm tắt

AbstractThe European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35–70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrolment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case–control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.

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Tài liệu tham khảo

10.1111/j.1365-2796.1993.tb00647.x

Day, 1999, EPIC–Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer, Br. J. Cancer., 80, 95

10.1007/978-3-642-85851-2

10.1093/oxfordjournals.aje.a010215

1997, Food, Nutrition and the Prevention of Cancer: A Global Perspective

10.1079/PHN2002396

10.1006/jfca.2000.0910

10.1093/oxfordjournals.aje.a117674

10.1093/ajcn/59.1.245S

10.1038/sj.ejcn.1601107

10.1016/S0169-2607(98)00088-1

10.1093/jn/131.1.170S

10.1093/oxfordjournals.aje.a117673

10.1093/ajcn/70.4.439

10.1093/ije/26.suppl_1.S161

10.1007/978-3-642-85849-9

10.1159/000012787

10.1002/ijc.2910150411

10.1079/PHN2002395

10.1159/000061829

10.1093/ije/20.4.900

Clavel-Chapelon, 1997, E3N, a French cohort study on cancer risk factors. E3N Group. Etude Epidémiologique auprès de femmes de l'Education Nationale, Eur. J. Cancer Prev., 6, 473, 10.1097/00008469-199710000-00007

10.1002/sim.4780130204

10.1079/BJN19940064

10.1038/sj.ejcn.1600608

10.1038/sj.ejcn.1601427

10.1006/jfca.2002.1089

10.1093/oxfordjournals.annonc.a058097

Tannenbaum, 1940, Initiation and growth of tumors; introduction: effects of underfeeding, Am. J. Cancer, 39, 335

10.1093/ije/26.suppl_1.S1

Keinan-Boker, 2002, Prospect–EPIC Utrecht: study design and characteristics of the cohort population, Eur. J. Epidemiol.

10.1093/ije/26.suppl_1.S6

10.1093/ije/26.suppl_1.S15

10.1097/00126097-200204000-00002

10.1159/000012786

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Public Health Nutrition

Tập 5 Số 6b

1113-1124

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