Estimates of acetaminophen (paracetomal)‐associated overdoses in the United States

Pharmacoepidemiology and Drug Safety - Tập 15 Số 6 - Trang 398-405 - 2006
Parivash Nourjah1, Syed Rizwanuddin Ahmad2, Claudia Karwoski2, Mary E. Willy2
1Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. [email protected]
2Office of Drug Safety, Division of Drug Risk Evaluation, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA

Tóm tắt

AbstractObjectiveTo estimate the number of acetaminophen‐associated overdoses in the United States and identify possible risk factors for intervention.MethodsThe investigators obtained estimates of acetaminophen‐associated overdoses using different national databases. Two emergency room databases, a hospital discharge database, a national mortality file, and a poison surveillance database were used to identify cases. The FDA's spontaneous reporting system was searched to identify possible root causes for overdoses.ResultsAnalysis of national databases show that acetaminophen‐associated overdoses account for about 56 000 emergency room visits and 26 000 hospitalizations yearly. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen‐associated overdoses; 100 of these are unintentional. The poison surveillance database showed near‐doubling in the number of fatalities associated with acetaminophen from 98 in 1997 to 173 in 2001. AERS data describe a number of possible causes for unintentional acetaminophen‐associated overdoses.ConclusionsEach year a substantial numbers of Americans experience intentional and unintentional acetaminophen‐associated overdoses that, in severe cases, lead to serious illness and possible death. This summary of a series of analyses highlights the need for strategies to reduce this public health burden. Copyright © 2005 John Wiley & Sons, Ltd.

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Pharmacoepidemiology and Drug Safety

Tập 15 Số 6

398-405

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