Erythroid Differentiation in Vitro Is Blocked by Cyclopamine, an Inhibitor of Hedgehog Signaling

Belloni, 1996, Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly, Nat. Genet., 14, 353, 10.1038/ng1196-353

Roessler, 1996, Mutations in the human Sonic Hedgehog gene cause holoprosencephaly, Nat. Genet., 14, 357, 10.1038/ng1196-357

Keys, 1999, Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution, Science, 283, 532, 10.1126/science.283.5401.532

Echelard, 1993, Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity, Cell, 75, 1417, 10.1016/0092-8674(93)90627-3

Wicking, 1999, The hedgehog signaling pathway in tumorigenesis and development, Oncogene, 18, 7844, 10.1038/sj.onc.1203282

Murone, 1999, Hedgehog signal transduction: from flies to vertebrates, Exp. Cell Res., 253, 25, 10.1006/excr.1999.4676

Porter, 1996, Cholesterol modification of hedgehog signaling proteins in animal development, Science, 274, 255, 10.1126/science.274.5285.255

Pepinsky, 1998, Identification of a palmitic acid-modified form of human Sonic hedgehog, J. Biol. Chem., 273, 14037, 10.1074/jbc.273.22.14037

Beachy, 1997, Multiple roles of cholesterol in hedgehog protein biogenesis and signaling, Cold Spring Harb. Symp. Quant. Biol., 62, 191, 10.1101/SQB.1997.062.01.025

Bitgood, 1995, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell–cell interaction in the mouse embryo, Dev. Biol., 172, 126, 10.1006/dbio.1995.0010

Murtaugh, 1999, Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling, Genes Dev., 13, 225, 10.1101/gad.13.2.225

Golden, 1999, Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly, Proc. Natl. Acad. Sci. USA, 96, 2439, 10.1073/pnas.96.5.2439

Duprez, 1996, Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb, Development, 122, 1821, 10.1242/dev.122.6.1821

Knezivic, 1997, Hoxd-12 differentially affects preaxial and postaxial chondrogenic branches in the limb and regulates Sonic hedgehog in a positive feedback loop, Development, 124, 4523, 10.1242/dev.124.22.4523

Moreno, 1999, Caudal is the Hox gene that specifies the most posterior Drosophile segment, Nature, 400, 873, 10.1038/23709

Wada, 1999, Sonic hedgehog signaling during digit pattern duplication after application of recombinant protein and expressing cells, Dev. Growth Differ., 41, 567, 10.1046/j.1440-169x.1999.00452.x

Zecca, 1995, Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing, Development, 121, 2265, 10.1242/dev.121.8.2265

Kingsley, 1994, The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms, Genes Dev., 8, 133, 10.1101/gad.8.2.133

Hogan, 1996, Bone morphogenetic proteins: Multifunctional regulators of vertebrate development, Genes Dev., 10, 1580, 10.1101/gad.10.13.1580

Iimura, 1994, Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein, Biochem. Biophys. Res. Commun., 201, 980, 10.1006/bbrc.1994.1798

Mead, 1996, BMP-4-responsive regulation of dorsal–ventral patterning by the homeobox protein Mix.1, Nature, 382, 357, 10.1038/382357a0

Hollnagel, 1999, Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells, J. Biol. Chem., 274, 19838, 10.1074/jbc.274.28.19838

Krumlauf, 1994, Hox genes in vertebrate development, Cell, 78, 191, 10.1016/0092-8674(94)90290-9

Bai, 2000, Smad6 as a transcriptional corepressor, J. Biol. Chem., 275, 8267, 10.1074/jbc.275.12.8267

Van Oostveen, 1999, The role of homeobox genes in normal hematopoiesis and hematological malignancies, Leukemia, 13, 1675, 10.1038/sj.leu.2401562

Bhatia, 1999, Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells, J. Exp. Med., 189, 1139, 10.1084/jem.189.7.1139

Ploemacher, 1999, Bone morphogenetic protein 9 is a potent synergistic factor for murine hemopoietic progenitor cell generation and colony formation in serum-free cultures, Leukemia, 13, 428, 10.1038/sj.leu.2401363

Detmer, 1999, Lineage-restricted expression of bone morphogenetic protein genes in human hematopoietic cell lines, Blood Cells Mol. Dis., 25, 310, 10.1006/bcmd.1999.0259

Cooper, 1998, Teratogen-mediated inhibition of target tissue response to Shh signaling, Science, 280, 1603, 10.1126/science.280.5369.1603

Incardona, 1998, The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction, Development, 125, 3553, 10.1242/dev.125.18.3553

Rutherford, 1979, Deficient heme synthesis as the cause of noninducibility of hemoglobin synthesis in a Friend erythroleukemia cell line, Cell, 16, 415, 10.1016/0092-8674(79)90017-5

Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction, Anal. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2

Lennon, G., Auffray, C., Polymeropoulos, M., and Soares, M. B.The I.M.A.G.E. Consortium: An integrated molecular analysis of genomes and their expression. Genomics33, 151–152.

Roelink, 1995, Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic hedgehogautoproteolysis, Cell, 81, 445, 10.1016/0092-8674(95)90397-6

Rowley, 1985, K562 human erythroleukemia cells demonstrate commitment, Blood, 65, 862, 10.1182/blood.V65.4.862.862

Lozzio, B. B., Lozzio, C. B., Bamberger, E. G., and Feliu, A. S.A multipotential leukemia cell line (K-562) of human origin. Proc. Soc. Exp. Biol. Med.166, 546–550.

Kitamura, 1989, Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin, Cell. Physiol., 140, 323, 10.1002/jcp.1041400219

Collins, 1978, Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds, Proc. Natl. Acad. Sci. USA, 75, 2458, 10.1073/pnas.75.5.2458

Radzun, 1983, Monocytic origin of the human hematopoietic cell line U-937 and its convertibility to macrophages evidenced by isoenzyme mapping, Int. J. Cancer, 31, 181, 10.1002/ijc.2910310208

Matsuo, 1998, Establishment and characterization of human B cell precursor-leukemia cell lines, Leuk. Res., 22, 567, 10.1016/S0145-2126(98)00050-2

Klein, 1975, An EBV-genome-negative cell line established from an American Burkitt lymphoma: Receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection, Intervirology, 5, 319, 10.1159/000149930

Minowada, 1972, Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes, J. Natl. Cancer Inst., 49, 891

Smith, 1988, Clinical and biologic characterization of T-cell neoplasias with rearrangements of chromosome 7 band q34, Blood, 71, 395, 10.1182/blood.V71.2.395.395

Weiss, 1984, The role of T3 surface molecules in the activation of human T cells: A two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level, J. Immunol., 133, 123, 10.4049/jimmunol.133.1.123

Srivastava, 1984, Phorbol ester-induced differentiation of a non-T/non-B human leukemic cell line (REH) to macrophage-like cells, Cancer Res., 44, 3017

Gaffield, 1984, Structure and stereochemistry of steroidal amine teratogens, Adv. Exp. Med. Biol., 177, 241, 10.1007/978-1-4684-4790-3_11

Stone, 1996, The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog, Nature, 384, 129, 10.1038/384129a0

Quirk, 1997, The Smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development, Cold Spring Harb. Symp. Quant. Biol., 62, 217, 10.1101/SQB.1997.062.01.027

Ito, 1999, Hedgehog signaling molecules in bone marrow cells at the initial stage of fracture repair, Biochem. Biophys. Res. Commun., 262, 443, 10.1006/bbrc.1999.1197

Incardona, 2000, Cholesterol in signal transduction, Curr. Opin. Cell Biol., 12, 193, 10.1016/S0955-0674(99)00076-9

Jensen, 1997, Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina, Development, 124, 363, 10.1242/dev.124.2.363

Oro, 1997, Basal cell carcinomas in mice overexpressing Sonic hedgehog, Science, 276, 817, 10.1126/science.276.5313.817

Rowitch, 1999, Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells, J. Neurosci., 19, 8954, 10.1523/JNEUROSCI.19-20-08954.1999

St-Jacques, 1999, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation, Genes Dev., 13, 2072, 10.1101/gad.13.16.2072

Wicking, 1999, The hedgehog signaling pathway in tumorigenesis and development, Oncogene, 18, 7844, 10.1038/sj.onc.1203282

Matisse, 1999, Gli genes in development and cancer, Oncogene, 18, 7852, 10.1038/sj.onc.1203243