Epidemiology and pathology of Paget’s disease of bone – a review

Springer Science and Business Media LLC - Tập 167 - Trang 2-8 - 2016
Elena Nebot Valenzuela1,2, Peter Pietschmann1
1Department of Pathophysiology and Allergy Research, Center of Pathophysiology Infectiology and Immunology, Medical University of Vienna, Vienna, Austria
2Department of Physiology, School of Pharmacy and Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

Tóm tắt

Paget’s disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. As a result, there is deformity and enlargement of the bone with a defective and disorganized pattern. Here, we review the epidemiology, etiology, pathology, macrostructure, histology, and quantitative histomorphometry findings of PDB. Hyperosteoclastosis and poor definition of the boundary between cortical and medullary bone are the main histological findings in PDB. Additionally, Pagetic bone is also characterized by hypertrophy and alteration of trabecular parameters.

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Tập 167

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