Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation
Tóm tắt
Từ khóa
Tài liệu tham khảo
Brentjens, 2013, CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia, Sci Transl Med, 5, 10.1126/scitranslmed.3005930
Kershaw, 2006, A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer, Clin Cancer Res, 12, 6106, 10.1158/1078-0432.CCR-06-1183
Abe, 1995, Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation, J Immunol, 154, 985, 10.4049/jimmunol.154.3.985
Finney, 1998, Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product, J Immunol, 161, 2791, 10.4049/jimmunol.161.6.2791