Enhanced IgG‐ and complement‐independent phagocytosis of sulfatide‐enriched human erythrocytes by human monocytes

FEBS Letters - Tập 311 - Trang 67-70 - 1992
Maria Vittoria Serra1, Franca Mannu2, Aida Matera1, Franco Turrini2, Paolo Arese2
1Istituto di Chimica Biologica e Fisiologia Generale, Università di Sassari, Sassari, Italy
2Dipartimento di Genetica, Biologia, Chimica Medica, Università di Torino, Torino, Italy

Tóm tắt

Phagocytosis by adherent human monocytes of human erythrocytes (RBC), sulfatide‐enriched by incubation with 10−12 to 10−9 M cerebroside sulfate, was enhanced approx. 6‐fold. Increased phagocytosis was observed only in RBC opsonized with fresh plasma, and not in non‐opsonized or serum‐opsonized RBC. Increased phagocytosis was immunoglobulin‐ and complement independent. Thrombospondin and von Willebrand factor, present in plasma but not in serum, and binding selectively to sulfatides, are likely mediators of the enhanced phagocytosis.

Tài liệu tham khảo

10.1093/oxfordjournals.jbchem.a131977 1974 Academic Press New York Deenen L.L.M. Van Gier J. De D.MacN. Surgenor The Red Blood Cell 147 211 10.1007/BF01644035 10.1016/0003-9861(88)90046-X 10.1073/pnas.82.5.1306 10.1016/S0021-9258(17)39381-X 10.1016/S0021-9258(17)35782-4 10.1016/0006-291X(78)91330-X 10.1016/0003-9861(63)90042-0 10.3109/00365516809076979 10.1016/S0021-9258(18)54327-1 1988 Cold Spring Harbor Laboratory Cold Spring Harbor NY E. Harlow D. Lane Antibodies - A Laboratory Manual 406 407 10.1016/0968-0004(83)90213-X 10.1182/blood.V67.5.1197.1197 1987 Intern. Soc. Thrombosis and Haemostasis and Leuven University Press Leuven J.E. Stadler M. Verstaete J. Vermylen H.R. Lijnen J. Arnout Thrombosis and Haemostasis 1987 61 79
Thông tin
Thông tin xuất bản

FEBS Letters

Tập 311

67-70

Thông tin tác giả