Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein

American Association for the Advancement of Science (AAAS) - Tập 269 Số 5220 - Trang 81-83 - 1995
Chao‐Lan Yu1, Debra J. Meyer2, George S. Campbell2, Andrew C. Larner3, Christin Carter‐Su2,4, Jessica Schwartz2, Richard Jove1
1Department of Microbiology and Immunology, and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Ml 48109, USA.
2Department of Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
3Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
4Internal Medicine - Metabolism, Endocrinology, and Diabetes

Tóm tắt

Cytokines and growth factors induce tyrosine phosphorylation of signal transducers and activators of transcription (STATs) that directly activate gene expression. Cells stably transformed by the Src oncogene tyrosine kinase were examined for STAT protein activation. Assays of electrophoretic mobility, DNA-binding specificity, and antigenicity indicated that Stat3 or a closely related STAT family member was constitutively activated by the Src oncoprotein. Induction of this DNA-binding activity was accompanied by tyrosine phosphorylation of Stat3 and correlated with Src transformation. These findings demonstrate that Src can activate STAT signaling pathways and raise the possibility that Stat3 contributes to oncogenesis by Src.

Từ khóa


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American Association for the Advancement of Science (AAAS)

Tập 269 Số 5220

81-83

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