Endoscopic resection combined with the Cryoballoon focal ablation system in the porcine normal esophagus: a preclinical study

BMC Gastroenterology - Tập 21 Số 1 - 2021
Hajime Sunakawa1, Yusuke Yoda1, Nobuyoshi Takeshita2, Hiro Hasegawa2, Kenji Takagi1, Toshikazu Kadota1, Takeo Fujita3, Tetsuo Akimoto4, Satoshi Fujii5, Tomonori Yano2
1Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Japan
2NEXT Medical Device Innovation Center, National Cancer Center Hospital East, Kashiwa, Japan
3Division of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Japan
4Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan
5Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo, Japan

Tóm tắt

Abstract Background The Cryoballoon focal ablation system (CbFAS) for dysplastic Barrett’s esophagus is simple, time-saving and has high therapeutic efficacy. This study aimed to evaluate the technical feasibility and tissue damage with combination therapy of endoscopic resection (ER) and CbFAS in porcine models. Methods Three pigs (A, B, and C) were included, and all ER procedures were performed by endoscopic mucosal resection using the Cap method (EMR). Combination therapy for each pig was performed as follows: (a) CbFAS was performed for a post-EMR mucosal defect for Pig A; (b) CbFAS for post-EMR scar for Pig B, and (c) EMR for post-CbFAS scar for Pig C. All pigs were euthanized at 32 days after the initial procedure, and the tissue damage was evaluated. Results All endoscopic procedures were followed as scheduled. None of the subjects experienced anorexia, rapid weight loss, bleeding, and perforation during the observation period. They were euthanized at 32 days after the initial endoscopic procedure. On histological assessment, there was little difference between the tissue that was treated with CbFAS alone and that treated with CbFAS in combination with ER. Conclusion Combination therapy with ER and CbFAS can be technically feasible, and its outcome was not significantly different from CbFAS alone in terms of tissue damage.

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BMC Gastroenterology

Tập 21 Số 1

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