Endocannabinoid Signaling in the Brain

American Association for the Advancement of Science (AAAS) - Tập 296 Số 5568 - Trang 678-682 - 2002
Rachel I. Wilson1, Roger A. Nicoll2
1Division of Biology 139-74, California Institute of Technology, Pasadena, CA 91125, USA
2Department of Cellular and Molecular Pharmacology and Department of Physiology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143–0450, USA.

Tóm tắt

The primary psychoactive ingredient in cannabis, Δ 9 -tetrahydrocannabinol (Δ 9 -THC), affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels in many brain regions, and several endogenous brain lipids have been identified as CB1 ligands. In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward across synapses, activating CB1 on presynaptic axons and suppressing neurotransmitter release. Cannabinoids may affect memory, cognition, and pain perception by means of this cellular mechanism.

Từ khóa


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We thank H. R. Bourne H. L. Fields D. Julius G. Kunos K. A. Moore and M. P. Stryker for comments on the manuscript. We also thank B. E. Alger and B. F. Cravatt for sharing data before publication. R.A.N. is a member of the Keck Center for Integrative Neuroscience and the Silvio Conte Center for Neuroscience Research. He is supported by grants from the National Institutes of Health and the Bristol-Myers Squibb Corporation.