Einfluss von Alkohol auf Homocystein-Metabolismus und Epigenetik

Andreotti F (2000) Homocysteine and risk of cardiovascular disease. J Thromb Thrombolysis 9:13-21

Barak AJ (1987) Effects of prolonged ethanol feeding on methionine metabolism in rat liver. Biochem Cell Biol 65:230-233

Bayerlein K (2005) Alcoholism associated hyper-homocysteinemia and previous withdrawal seizures. Biol Psychiatry 57:1590-1593

Beal MF (1992) Mechanisms of excitotoxicity in neurologic diseases. FASEB J 6:3338-3344

Bird A. (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16:6-21.

Bleich S (2000) Oxidative stress and an altered methionine metabolism in alcoholism. Neurosci Lett. 293:171-174.

Bleich S (2000) Elevated homocysteine levels in alcohol withdrawal. Alcohol Alcohol 35:351-354

Bleich S (2000) Homocysteine and alcoholism. J Neural Transm. Suppl 60:187-196

Bleich S (2000) Red wine, spirits, beer and serum homocysteine. Lancet 356:512

Bleich S (2000) Homocysteine is a predictor of alcohol withdrawal seizures. NeuroReport 11:2749-2752

Bleich S (2001) Moderate alcohol consumption in social drinkers raises plasma homocysteine levels:a contradiction to the “French paradox”? Alcohol Alcohol 36:189-192

Bleich S (2003) Hyperhomocysteinemia as a new risk factor for brain shrinkage in patients with alcoholism. Neurosci Lett. 335:179-182

Bleich S (2003) Exzitatorische Neurotransmission bei chronischem Alkoholismus. Fortschr Neurol Psychiatr. 71:36-44.

Bleich S (2004) Folsäure gegen Hyperhomocysteinämie. Ein neuer Ansatz zur Prävention und Therapie Alkoholismus-bedingter Störungen? Nervenarzt 74:425-430.

Bleich S (2004) Homocysteine as a neurotoxin in chronic alcoholism. Prog Neuro-Psychopharmacol Biol Psychiatry 28:453-464.

Bleich S (2003) Folsäure gegen Hyperhomocysteinämie - Schlüssel zum Schutz von Nervenzellen? DNP 9:42-44

Bleich S (2005) Evidence of elevated homocysteine levels in alcoholism. The Franconian Alcoholism Research Studies (FARS). Alcohol Clin Exp Res. 29:334-336

Bleich S (2003) Memantine in moderate-to-severe Alzheimer`s disease. N Engl J Med. 349:609-610

Bleich S (2006) Epigenetic DNA hypermethylation of the HERP gene promoter induces downregulation of its mRNA expression in patients with alcohol dependence. Alcohol Clin Exp Res. 30:587-91.

Bleich S (2006) An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures. Epilepsia 47:934-8.

Bönsch D (2004) Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm. 111:1611-1616

Bönsch D (2005) DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport 16:167-170.

Bönsch D (2005) Joint analysis of the NACP-REP1 marker within the alpha synuclein gene concludes association with alcohol dependence. Hum Mol Genet. 14:967-971

Bönsch D (2005) Alpha synuclein protein levels are elevated in alcoholism and are linked to craving. Alcohol Clin Exp Res. 29:763-765

Bönsch D (2006) Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm. 113:1299-304

Bönsch D (2004) Elevated alpha synuclein mRNA levels are associated with craving in patients with alcoholism. Biol Psychiatry 56:984-986.

Chen X (1997) Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA receptor proteins in brain synaptic membranes. J Neurochem. 69:1559-1569

Clarke R (1998) Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 55:1449-1455

Cravo ML (1996) Hyperhomocysteinemia in chronic alcoholism:correlation with folate, vitamin B-12, and vitamin B-6 status. Am J Clin Nutr. 63:220-224

Eikelboom JW (1991) Homocyst(e)ine and cardiovascular disease:A critical review of the epidemiologic evidence. Ann Intern Med. 131:363-375

Finkelstein JD (1974) Methionine metabolism in mammals:The biochemical basis for homocystinuria. Metabolism 23:387-398

Follesa P (1996) Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide. J Biol Chem. 271:13297-13299

Frieling H, Römer KD, Beyer S, Hillemacher T, Wilhelm J, Jacoby GE, de Zwaan M, Kornhuber J, Bleich S. (2008) Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders. J Psychiatr Res 42:83-86

Gibson JB (1964) Pathological findings in homocystinuria. J Clin Pathol. 17:427-437

Graeme JH (1999) Homocysteine and vascular disease. Lancet 354:407-413

Hu XJ (1996) Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons. Mol Brain Res. 36:211-218

Hultberg B (1993) Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res. 17:687-689

Kang S-S (1987) Homocysteinemia due to folate deficiency. Metabolism 36:458-462

Kenyon SH (1998) The effect of ethanol and its metabolites upon methionine synthase activity in vitro. Alcohol 15:305-309

Kokame K (2000) Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. J Biol Chem. 275:32846-32853.

Kornhuber J (1987) Alcohol consumption and blood-cerebrospinal fluid barrier dysfunction in man. Neurosci Lett. 79:218-222

Kubova H (1995) Seizures induced by homocysteine in rats during ontogenesis. Epilepsia 36:750-756

Kurth C (2001) Risk assessment of alcohol withdrawal seizures with a Kohonen Feature Map. NeuroReport 12:45-49

Lenz B (2006) Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites. Exp Cell Res. 312:4049-55

Liang T (2003) Alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Proc Natl Acad Sci U S A 100:4690-4695.

Lipton SA (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 94:5923-5928

Nygård O (1998) Major lifestyle determinants of plasma total homocysteine distribution:the Hordaland Homocysteine Study. Am J Clin Nutr. 67:263-270

O´Donnell C (2005) Stephens T.The significance of homocysteine levels in schizophrenia. Am J Psychiatry. 162:1387-8

Rozen R (2000) Genetic modulation of homocysteinemia. Semin Thromb Hemost. 26:255-261

Sachdev PS (2002) Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals. Neurology 58:1539-1541

Seitz HK (1995) Alkohol und Krebs. In:Seitz HK, Lieber CS, Simanowski UA (Hrsg.):Alkoholbedingte Organschäden. Leipzig/ Heidelberg:JA Barth-Verlag

Selhub J (1999) Homocysteine metabolism. Annu Rev Nutr. 19:217-246

Statistisches Bundesamt Deutschland (2007) Die 20 häufigsten Hauptdiagnosen der vollstationär behandelten männlichen Patienten (einschl. Sterbe- und Stundenfälle) nach der International Statistical Classification of Diseases and Related Health Problems (ICD-10); www.destatis.de

Stickel F (2000) Effekt of Chronic Alcohol Consumption on Total Plasma Homocysteine Level in Rats. Alcohol Clin Exp Res. 24:259-264

Tsai G (1995) The glutamatergic basis of human alcoholism. Am J Psychiatry 152:332-340

Tsai GE (1998) Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal, Am J Psychiatry 155:726-732

Ueland PM (1993) Total homocysteine in plasma and serum. Methods and clinical applications. Clin Chem. 39:1764-1779

Wilhelm J (2005) Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism. J Neural Transm. DOI:10.1007/s00702-005-0333-1