Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

The Lancet Oncology - Tập 10 Số 5 - Trang 459-466 - 2009
Roger Stupp1, Monika E. Hegi1, Warren Mason2, Martin J. van den Bent3, Martin J.B. Taphoorn4, Robert C. Janzer1, Samuel K. Ludwin5, Anouk Allgeier6, Barbara Fisher7, Karl Bélanger8, Peter Hau9, Alba A. Brandes10, Johanna M. M. Gijtenbeek11, Christine Marosi12, Charles J. Vecht3, Karima Mokhtari13, Pieter Wesseling11, S. Villà14, Elizabeth Eisenhauer15, Thierry Gorlia6, Michael Weller16, Denis Lacombe6, J. Gregory Cairncross17, René‐Olivier Mirimanoff1
1Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
2Princess Margaret Hospital, University of Toronto, Ontario, Canada
3Daniel de Hoed Cancer Centre/Erasmus Medical Centre, Rotterdam, Netherlands
4University Medical Centre, Utrecht, Netherlands
5Queens University, Kingston, Ontario, Canada
6European Organisation for Research and Treatment of Cancer, Brussels, Belgium
7University of Western Ontario London, Ontario, Canada
8Hôpital Notre Dame du Centre Hospitalier Universitaire, Montreal, Quebec, Canada
9University Neurology Clinic, Regensburg, Germany
10Azienda-Ospedale Università, Padova, Italy
11University Medical Centre St. Radboud, Nijmegen, Netherlands
12Medical University of Vienna, Vienna, Austria
13Hôpitaux de Paris and Institut National de la Santé et de la Recherche Médicale UMR711, Groupe Hospitalier Pitié-Salpêtrière, Paris, France
14Institut Català d’Oncologia Hospital Duran i Reynals, Barcelona, Spain
15National Cancer Institute of Canada, Clinical Trials Group, Kingston, Ontario, Canada
16University of Tübingen, Medical School, Tübingen, Germany
17University of Calgary, calgary, Alberta, canada

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