Effects of new combinative antioxidant FeAOX-6 and α-tocotrienol on macrophage atherogenesis-related functions

Amundson, 1999, Fluorometric method for the enzymatic determination of cholesterol, J. Biochem. Biophys. Methods, 38, 43, 10.1016/S0165-022X(98)00036-0

Asmis, 2000, Vitamin E supplementation of human macrophages prevents neither foam cell formation nor increased susceptibility of foam cells to lysis by oxidized LDL, Arterioscler. Thromb. Vasc. Biol., 20, 2078, 10.1161/01.ATV.20.9.2078

Balsinde, 1994, Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes, Proc. Natl. Acad. Sci. U. S. A., 91, 11060, 10.1073/pnas.91.23.11060

Barrios-Rodiles, 1999, Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha, J. Immunol., 163, 963, 10.4049/jimmunol.163.2.963

Bradford, 1976, A sensitive method for quantitation of microgram quantities of protein utilizing the principle of dye-binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3

Britton, 1995, Structure and properties of carotenoids in relation to function, FASEB J., 9, 1551, 10.1096/fasebj.9.15.8529834

Brown, 1975, Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts, J. Clin. Invest., 55, 783, 10.1172/JCI107989

Brown, 1983, Lipoprotein metabolism in the macrophages: implications for cholesterol deposition in atherosclerosis, Ann. Rev. Biochem., 52, 223, 10.1146/annurev.bi.52.070183.001255

Cherubini, 2005, Role of antioxidants in atherosclerosis: epidemiological and clinical update, Curr. Pharm. Des., 11, 2017, 10.2174/1381612054065783

Chisolm, 2000, The oxidative modification hypothesis of atherogenesis: an overview, Free Radic. Biol. Med., 28, 1815, 10.1016/S0891-5849(00)00344-0

Douglas, 1986, Vitamin E inhibits platelet phospholipase A2, Biochem. Biophys. Acta, 876, 639, 10.1016/0005-2760(86)90053-6

Dugas, 1998, Impact of LDL carotenoid and alpha-tocopherol content on LDL oxidation by endothelial cells in culture, J. Lipid Res., 39, 999, 10.1016/S0022-2275(20)33867-0

Fox, 1997, N-acetylcysteine and alpha-tocopherol reverse the inflammatory response in activated rat Kupffer cells, J. Immunol., 158, 5418, 10.4049/jimmunol.158.11.5418

Gey, 1994, Optimum plasma levels of antioxidant micronutrients. Ten years of antioxidant hypothesis on arteriosclerosis, Bibl. Nutr. Dieta, 51, 84

Hengartner, 1992, Synthesis, isolation, and NMR-spectroscopic characterization of four teen (Z)-isomers of lycopene and some acetylenic didehydro- and tetrahydrolycopenes, Helv. Chim. Acta, 75, 1848, 10.1002/hlca.19920750611

Hsu, 1996, Inhibition of macrophage scavenger receptor activity by tumor necrosis factor-alpha is transcriptionally and post-transcriptionally regulated, J. Biol. Chem., 271, 7767, 10.1074/jbc.271.13.7767

Jiang, 2000, Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells, Proc. Natl. Acad. Sci. U. S. A., 97, 11494, 10.1073/pnas.200357097

Jung, 2004, Effects of major dietary antioxidants on inflammatory markers of RAW 264.7 macrophages, Biofactors, 21, 113, 10.1002/biof.552210122

Kamat, 2000, Oxidative damage to mitochondria in normal and cancer tissues, and its modulation, Toxicology, 155, 73, 10.1016/S0300-483X(00)00279-1

Kiemer, 2002, Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoicacid in rat Kupffer cells and in RAW 264.7 murine macrophages, Immunol. Cell Biol., 80, 550, 10.1046/j.1440-1711.2002.01124.x

Morrow, 1992, Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation, J. Clin. Invest., 90, 2502, 10.1172/JCI116143

Munteanu, 2004, Anti-atherosclerotic effects of vitamin E—myth or reality?, J. Cell. Mol. Med., 8, 59, 10.1111/j.1582-4934.2004.tb00260.x

Napolitano, 2003, Activation of protein Kinase C by phorbol esters in human macrophages reduces the metabolism of modified LDL by down-regulation of scavenger receptor activity, Int. J. Biochem. Cell Biol., 35, 1127, 10.1016/S1357-2725(03)00038-4

Napolitano, 2005, Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages, Eur. J. Clin. Invest., 35, 482, 10.1111/j.1365-2362.2005.01523.x

Nathens, 2001, Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability, Shock, 16, 361, 10.1097/00024382-200116050-00007

O'Leary, 2004, Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription, Mutat. Res., 551, 245, 10.1016/j.mrfmmm.2004.01.015

Palozza, 2002, Design, synthesis, and antioxidant activity of FeAOX-6, a novel agent deriving from a molecular combination of the chromanyl and polyisoprenyl moieties, Free Radic. Biol. Med., 33, 1724, 10.1016/S0891-5849(02)01168-1

Pearce, 1992, Hypocholesterolemic activity of synthetic and natural tocotrienols, J. Med. Chem., 35, 3595, 10.1021/jm00098a002

Qureshi, 1986, The structure of an inhibitor of cholesterol biosynthesis isolated from barley, J. Biol. Chem., 261, 10544, 10.1016/S0021-9258(18)67419-8

Schneider, 2005, Chemistry and biology of vitamin E, Mol. Nutr. Food Res., 49, 7, 10.1002/mnfr.200400049

Serbinova, 1991, Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol, Free Radic. Biol. Med., 10, 263, 10.1016/0891-5849(91)90033-Y

Shige, 1998, Vitamin E reduces cholesterol esterification and uptake of acetylated low density lipoprotein in macrophages, Lipids, 33, 1169, 10.1007/s11745-998-0320-9

Skeen, 1996, Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines, J. Immunol., 156, 1196, 10.4049/jimmunol.156.3.1196

Stahl, 2000, Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans, Am. J. Clin. Nutr., 71, 795, 10.1093/ajcn/71.3.795

Steinberg, 2002, Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime, Nat. Med., 8, 1211, 10.1038/nm1102-1211

Suzuki, 1997, The multiple roles of macrophage scavenger receptors (MSR) in vivo: resistance to atherosclerosis and susceptibility to infection in MSR knockout mice, J. Atheroscler. Thromb., 4, 1, 10.5551/jat1994.4.1

Teupser, 1999, α-Tocopherol down-regulates scavenger receptor activity in macrophages, Atherosclerosis, 144, 109, 10.1016/S0021-9150(99)00040-4

Theriault, 2002, Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes, Atherosclerosis, 160, 21, 10.1016/S0021-9150(01)00540-8

van Lenten, 1992, Lipopolysaccharide-induced inhibition of scavenger receptor expression in human monocyte-macrophages is mediated through tumor necrosis factor-alpha, J. Immunol., 148, 112, 10.4049/jimmunol.148.1.112

von der Thusen, 2003, Interleukins in atherosclerosis: molecular pathways and therapeutic potential, Pharmacol. Rev., 55, 133, 10.1124/pr.55.1.5

Wayner, 1985, Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation. The important contribution made by plasma proteins, FEBS Lett., 18, 733

Witztum, 2005, You are right too!, J. Clin. Invest., 115, 2072, 10.1172/JCI26130

Wu, 1998, Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E, Am. J. Physiol., 275, C661, 10.1152/ajpcell.1998.275.3.C661

Wu, 2005, Vitamin E increases production of vasodilator prostanoids in human aortic endothelial cells through opposing effects on cyclooxygenase-2 and phospholipase A2, J. Nutr., 135, 1847, 10.1093/jn/135.8.1847