Effects of CYP2C9 and VKORC1 on INR Variations and dose Requirements During Initial Phase of Anticoagulant Therapy

Pharmacogenomics - Tập 9 Số 9 - Trang 1237-1250 - 2008
M. Spreafico1, Corrado Lodigiani2, Yvonne van Leeuwen3, D. Pizzotti4, L. Rota2, F.R. Rosendaal3, Pier Mannuccio Mannucci1, Flora Peyvandi1
1A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan and Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, via Pace 9, 20122 Milan, Italy.
2Thrombosis Center, IRCCS Istituto Clinico Humanitas, Italy, via Manzoni, 56, 20089 Rozzano, Milan, Italy.
3Department of Clinical Epidemiology, Leiden University Medical Center, and Einthoven Laboratory for Experimental Vascular Medicine, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
4Department of Transfusional Medicine Hematology, SIMT, S.Paolo Hospital, Via Di Rudini' Antonio, 20142 Milan, Italy.

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