Effects of fluticasone propionate dosage in an experimental model of feline asthma

Journal of Feline Medicine and Surgery - Tập 12 - Trang 91-96 - 2010
Leah A. Cohn1, Amy E. DeClue1, Rachael L. Cohen1, Carol R. Reinero1
1University of Missouri, College of Veterinary Medicine, Department of Veterinary Medicine and Surgery, Columbia, MO, USA

Tóm tắt

Cats with inflammatory bronchial disease are usually treated with glucocorticoid (GC) drugs to reduce airway inflammation. Inhalant GC delivery can preserve airway effects while systemic effects are minimized. An appropriate dosage regimen for inhaled GC in cats has not been investigated. A blinded, randomized, cross-over study design was used to investigate the ability of three different dosages of the inhalant GC fluticasone propionate delivered by metered dose inhaler to ameliorate eosinophilic airway inflammation in cats with experimentally induced allergic airway inflammation. Further, suppression of the hypothalamic–pituitary–adrenal axis (HPAA) at each dose was assessed. Fluticasone administered at dosages of 44, 110, or 220 μg q 12 h reduced airway eosinophilia by 74%, 82%, or 81%, respectively (no difference). None of the dose regimens tested caused HPAA suppression. We conclude that a twice daily dosage of 44 μg fluticasone should be evaluated for the management of cats with naturally occurring inflammatory bronchial disease.

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Thông tin
Thông tin xuất bản

Journal of Feline Medicine and Surgery

Tập 12

91-96

Thông tin tác giả