Effects of des-glycinamide9-[arginine8] vasopressin upon spatial memory in the hole-board search task
Tóm tắt
The hole-board search task (HBST), a spatial learning test, was used to measure errors, working memory, reference memory, sequence, and response bias. Various dosages of desglycinamide9-[arginine8] vasopressin (DGAVP; 0.17, 0.5, 1, 3, and 10 µg) were administered in double blind experiments 1 h prior to six training sessions in the HBST. Body weight loss was a covariant in a repeated measures multivariate analysis of variance. Reliable changes in all dependent variables were observed. DGAVP dosages of 0.17 and 0.5 µg × sessions were both significant for the error measure, relative to saline controls. Both dosages showed increased errors (i.e., less learning), relative to saline controls. Pretreatment with DGAVP 0.5 µg × sessions produced a significant decrease in working memory performance, relative to saline controls. Pretreatment with DGAVP 1 µg × sessions was significant and revealed improved performance on errors, working memory, reference memory, and sequence variables, relative to saline controls. DGAVP 10 µg decreased the sequence of visits to food holes significantly. DGAVP 0.17 µg significantly decreased first hole food visits, relative to controls. The results offer further evidence that DGAVP effects performance errors (learning), working memory (short-term memory), reference memory (long-term memory), and sequence of visits to food holes (spatial memory). The dosage of DGAVP is critical in facilitating performance in the HBST.
Tài liệu tham khảo
citation_journal_title=Behavioral & Neural Biology; citation_title=Vasopressin injections impair working memory in a delayed matching to sample task in rats; citation_author=T Alexinsky, J Alliot; citation_volume=48; citation_publication_date=1987; citation_pages=167-182; citation_doi=10.1016/S0163-1047(87)90710-2; citation_id=CR1
citation_journal_title=Physiology & Behavior; citation_title=Food-restriction interacts with vasopressin modulation of activity; citation_author=J Alliot, T Alexinsky; citation_volume=50; citation_publication_date=1991; citation_pages=213-220; citation_doi=10.1016/0031-9384(91)90523-Q; citation_id=CR2
citation_journal_title=Peptides; citation_title=Dose-dependent effects of DDAVP on memory in healthy young adult males: A preliminary study; citation_author=B E Beckwith, R E Till, C R Reno, R E Poland; citation_volume=11; citation_publication_date=1990; citation_pages=473-476; citation_doi=10.1016/0196-9781(90)90045-7; citation_id=CR3
citation_journal_title=Neuropsychobiology; citation_title=Influence of desglycinamide-(arg8)-vasopressin on memory in healthy subjects; citation_author=J Bruins, A Kumar, D Schneider-Helmert; citation_volume=23; citation_publication_date=1990; citation_pages=82-88; citation_doi=10.1159/000119432; citation_id=CR4
citation_journal_title=American Journal of Physiology; citation_title=Influence of posterior pituitary on avoidance learning and escape behavior; citation_author=D Wied; citation_volume=207; citation_publication_date=1964; citation_pages=255-259; citation_id=CR5
citation_journal_title=International Journal of Neuropharmacology; citation_title=The influence of the posterior and intermediate lobe of the pituitary and pituitary peptides on the conditioned avoidance response in rats; citation_author=D Wied; citation_volume=4; citation_publication_date=1965; citation_pages=157-167; citation_doi=10.1016/0028-3908(65)90005-5; citation_id=CR6
citation_journal_title=Nature; citation_title=Central target for the behavioral effects of vasopressin neuropeptides; citation_author=D Wied, O Gaffori, J M Ree, W Jong; citation_volume=308; citation_publication_date=1984; citation_pages=286-288; citation_doi=10.1038/308286a0; citation_id=CR7
citation_title=Vasopressin effects on the central nervous system; citation_inbook_title=Peptide hormones: Effects and mechanisms of action; citation_publication_date=1988; citation_pages=97-140; citation_id=CR8; citation_author=D Wied; citation_author=M Joëls; citation_author=J P H Burbach; citation_author=W Jong; citation_author=E R Kloet; citation_author=O W Gaffori; citation_author=I J Urban; citation_author=J M Ree; citation_author=T B Wimersma Greidanus; citation_author=H D Veldhuis; citation_author=D H G Versteeg; citation_author=V M Wiegant; citation_publisher=CRC Press
citation_journal_title=Neuropharmacology; citation_title=Can vasopressin alone act as an unconditioned stimulus to produce passive avoidance behavior in rats in a typical memory experiment?; citation_author=I S Ebenezer; citation_volume=27; citation_publication_date=1988; citation_pages=903-907; citation_doi=10.1016/0028-3908(88)90117-7; citation_id=CR9
citation_journal_title=Behavioural Brain Research; citation_title=Can aversive properties of (peripherally-injected) vasopressin account for its putative role in memory?; citation_author=A Ettenberg, D Kooy, M Moal, G F Koob, F E Bloom; citation_volume=7; citation_publication_date=1983; citation_pages=331-350; citation_doi=10.1016/0166-4328(83)90024-4; citation_id=CR10
citation_journal_title=Psychopharmacology; citation_title=Vasopressin but not oxytocin enhances cortical arousal: An integrative hypothesis on behavioral effects of neurohypophyseal hormones; citation_author=G F Fehm-Wolfsdorf, G Bachholz, J Born, K Voigt, L H Fehm; citation_volume=94; citation_publication_date=1988; citation_pages=496-500; citation_doi=10.1007/BF00212844; citation_id=CR11
citation_journal_title=Animal Behaviour; citation_title=Effects of time of day and food deprivation on exploratory activity in the rat; citation_author=S E File, S Day; citation_volume=20; citation_publication_date=1972; citation_pages=758-762; citation_doi=10.1016/S0003-3472(72)80148-9; citation_id=CR12
citation_title=Vasopressin and human behavior; citation_inbook_title=Vasopressin: Principles and properties; citation_publication_date=1988; citation_pages=549-578; citation_id=CR13; citation_author=J Jolles; citation_publisher=Plenum
citation_journal_title=Peptides; citation_title=Vasopressin(1–8) (des-glycinamide9-[arg8]vasopressin) is an endogenous peptide present in rat plasma; citation_author=F Laczi, J P Burbach, A A Kleij, D Wied, V M Wiegant; citation_volume=12; citation_publication_date=1991; citation_pages=329-332; citation_doi=10.1016/0196-9781(91)90021-G; citation_id=CR14
citation_journal_title=Journal of Biological Chemistry; citation_title=Pituitary peptides. An octapeptide that stimulates conditioned avoidance acquisition in hypophysectomized rats; citation_author=S Lande, A Witter, D Wied; citation_volume=246; citation_publication_date=1971; citation_pages=2058-2062; citation_id=CR15
citation_journal_title=Psychoneuroendocrinology; citation_title=Behavioral effects of peripheral administration of arginine vasopressin: A review of our search for a mode of action and a hypothesis; citation_author=M Moal, R Dantzer, P Mormede, A Baduel, C Lebrun, A Ettenberg, D Kooy, J Wenger, S Deyo, G F Koob, F E Bloom; citation_volume=9; citation_publication_date=1984; citation_pages=319-341; citation_doi=10.1016/0306-4530(84)90042-8; citation_id=CR16
citation_title=SPSS/PC+4.0 base manual for the IBM PC/XT/AT & PS/2; citation_publication_date=1990; citation_id=CR17; citation_author=J Norusis; citation_publisher=SPSS, Inc
citation_journal_title=Brain Research Bulletin; citation_title=Types of memory or attention? Impairments after lesions of the hippocampus and limbic ventral tegmentum; citation_author=R D Oades; citation_volume=7; citation_publication_date=1981; citation_pages=221-226; citation_doi=10.1016/0361-9230(81)90086-1; citation_id=CR18
citation_journal_title=Life Sciences; citation_title=Long term facilitation of social recognition in rats by vasopressin related peptides: A structure-activity study; citation_author=P Popik, J M Ree; citation_volume=50; citation_publication_date=1992; citation_pages=567-572; citation_doi=10.1016/0024-3205(92)90368-Y; citation_id=CR19
citation_journal_title=Psychopharmacology; citation_title=A critique of the vasopressin-memory hypothesis; citation_author=A Sahgal; citation_volume=83; citation_publication_date=1984; citation_pages=215; citation_doi=10.1007/BF00464785; citation_id=CR20
citation_journal_title=Psychopharmacology; citation_title=Opposing effects of vasopressin on matching versus non-matching to position: Further evidence for response, not memory, modulation; citation_author=A Sahgal, A B Keith, S Lloyd; citation_volume=102; citation_publication_date=1990; citation_pages=130-135; citation_doi=10.1007/BF02245757; citation_id=CR21
citation_journal_title=Peptides; citation_title=Differential effects of DGAVP on acquisition and extinction of active avoidance behavior; citation_author=J Skopkova, G Croiset, D Wied; citation_volume=12; citation_publication_date=1991; citation_pages=471-475; citation_doi=10.1016/0196-9781(91)90086-5; citation_id=CR22
citation_journal_title=Behavioral Neuroscience; citation_title=Improvement of memory by a vasopressin fragment: Importance of individual differences in mnemonic function; citation_author=B J Strupp; citation_volume=103; citation_publication_date=1989; citation_pages=743-754; citation_doi=10.1037/0735-7044.103.4.743; citation_id=CR23
citation_journal_title=Behavioral Neuroscience; citation_title=Enhancement and impairment of memory retrieval by a vasopressin metabolite: An interaction with the accessibility of the memory; citation_author=B J Strupp, M Bunsey, B Bertsche, D Levitsky, M Kesler; citation_volume=104; citation_publication_date=1990; citation_pages=268-276; citation_doi=10.1037/0735-7044.104.2.268; citation_id=CR24
citation_title=
-
; citation_publication_date=1978; citation_id=CR25; citation_author=M P Vawter; citation_publisher=California State University
citation_journal_title=Physiology & Behavior; citation_title=Effects of desglycinamidelysine vasopressin on a conditioned taste aversion in rats; citation_author=M P Vawter, K F Green; citation_volume=25; citation_publication_date=1980; citation_pages=851-854; citation_doi=10.1016/0031-9384(80)90303-0; citation_id=CR26
citation_journal_title=Physiology & Behavior; citation_title=Hole board food search task in rats: Effects of hole depths and food deprivation; citation_author=M P Vawter, J M Ree; citation_volume=45; citation_publication_date=1989; citation_pages=891-895; citation_doi=10.1016/0031-9384(89)90211-4; citation_id=CR27